| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
We newly found and reported that the expression of IL-12B(p40) was up-regulated by DcR3 specifically in rheumatoid fibloblast-like synovial fibroblasts (RA-FLS) in Molecular Medicine Reports. We also reported that Decoy receptor 3 down-regulates centrosomal protein 70kDa specifically in rheumatoid synovial fibroblasts in Modern Rheumatology. Further, we reported the expression profiling of genes in RA-FLS regulated by tumor necrosis factor-like ligand 1A in Biomedical Reports. Consequently, DcR3-TL1A signaling on RA synovial fibroblasts is shown as a possible new treatment target of RA.
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