| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Outline of Final Research Achievements |
Previously, we reported that glutathione have a role in molecular mechanism of osteoclast differentiation. To clarify mechanisms of the stimulatory effect of glutathione on osteoclast differentiation, we tried to establish knockout mice of glutathione-related molecules which are expressed specifically in osteoclasts. Using CRISPR-Cas9 system, we were able to establish a knockout mice strain of glutathione-related molecules.
|
