Analysis for pathogenesis of shoulder degenerative disease
| Project/Area Number |
15K10484
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|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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|---|
| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中島 利博 東京医科大学, 医学部, 教授 (90260752)
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|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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|---|
| Keywords | 肩腱板断裂 / 筋内脂肪変性 / 筋脂肪変性 / 腱板断裂 |
|---|
| Outline of Final Research Achievements |
Although various surgical procedures have been developed, the re-tear rate after rotator cuff repair remains high with severe fat infiltration. In this study, we addressed the role of high-mobility group box 2 (HMGB2) in adipogenesis of mesenchymal stem cells (MSCs) and fat infiltration into skeletal muscles. HMGB2 was highly expressed in undifferentiated MSCs and co-localized with platelet-derived growth factor receptor α (PDGFRA) known as an MSC-specific marker. Under the deficiency of HMGB2, the expressions of adipogenesis-related molecules were reduced, and adipogenic differentiation is substantially impaired in MSCs. Moreover, HMGB2+ cells were generated in the muscle belly of rat supraspinatus muscles after rotator cuff transection, and some of these cells expressed PDGFRA in intra-muscular spaces. These findings suggest that the enhance expression of HMGB2 induces the adipogenesis of MSCs and the fat infiltration into skeletal muscles through the cascade of HMGB2-PDGFRA.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Screening for musculoskeletal problems in Japanese schoolchildren: a cross-sectional study nested in a cohort2016
Author(s)
Yamaguchi N, Chosa E, Yamamoto K, Kawahara K, Hamada H, Taniguchi N, Tajima T, Funamoto T, Kurogi S, Ota T, Nakamura S.
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Journal Title
Public Health
Volume: 139
Pages: 189-197
DOI
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Peer Reviewed
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[Book] 肩関節再建術2017
Author(s)
谷口昇
Total Pages
16
Publisher
メディカ出版
ISBN
9784840461832
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[Book] 関節外科2016
Author(s)
谷口昇、帖佐悦男
Total Pages
2
Publisher
メジカルビュー社
Related Report
