Roles of Atoh8 in differentiation of osteoblasts and adipocytes
Project/Area Number |
15K10486
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | Kagoshima University |
Principal Investigator |
MAEDA Shingo 鹿児島大学, 医歯学総合研究科, 特任准教授 (60353463)
|
Co-Investigator(Kenkyū-buntansha) |
河村 一郎 鹿児島大学, 医学部・歯学部附属病院, その他 (90535832)
小宮 節郎 鹿児島大学, 医歯学域医学系, 教授 (30178371)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | Atoh8 / 骨芽細胞 / BMP / 骨芽細胞分化 |
Outline of Final Research Achievements |
Number and bone-forming activity of osteoblasts in bone marrow decreases in aging bone, which leads to osteoporosis. However, the mechanism is not fully understood. We analyzed function of Atoh8, a novel direct target gene of canonical bone morphogenetic protein (BMP) signaling, in osteoblasts in vivo and in vitro.siRNA-mediated loss of Atoh8 promoted osteoblast differentiation, however, bone formation parameters were not altered in Atoh8 knockout (KO) mice, assessed by micro-CT and bone morphohistometry analysis.Instead, osteoclast number and bone resorption was increased in KO mice bone, and bone volume was significantly reduced.Rankl/Opg expression ratio in KO osteoblast was increased which enhanced differentiation of osteoclasts.
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Report
(4 results)
Research Products
(15 results)
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[Presentation] Regulation of osteoblast differentiation by a novel BMP signaling target gene Atoh82017
Author(s)
Yuhei Hahiro, Shingo Maeda, Masato Morikawa, Daizo Koinuma, Naohiro Shinohara, Kanehiro Matsuyama, Ichiro Kawamura, Yasuhiro Ishidou, Ryoichiro Kageyama4, Kohei Miyazono, Setsuro Komiya
Organizer
Orthopaedic Research Society Annual Meeting 2017
Place of Presentation
San Diego, CA, USA
Year and Date
2017-03-19
Related Report
Int'l Joint Research
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[Presentation] Loss of BMP-inducible gene Atoh8 in mice decreases bone mass.2017
Author(s)
Yahiro Y, Maeda S, Morikawa M, Koinuma D, Shinohara N, Matsuyama K, Sakuma D, Ishidou Y, Kageyama R, Miyazono K, Komiya S
Organizer
Joint Meeting of the Australian & New Zealand Bone & Mineral Society & the International Federation of Musculoskeletal Research Societies in Conjunction with the JSBMR
Related Report
Int'l Joint Research
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[Presentation] BMPシグナルによる骨芽細胞分化制御2016
Author(s)
前田真吾, 八尋雄平, 森川真大, 鯉沼代造, 篠原直弘, 松山金寛, 河村一郎, 石堂康弘, 影山龍一郎, 宮園浩平, 小宮節郎
Organizer
第31回日本整形外科学会基礎学術集会
Place of Presentation
福岡国際会議場(福岡県・福岡市)
Year and Date
2016-10-13
Related Report
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[Presentation] BMP誘導遺伝子Atoh8の骨芽細胞分化における機能2016
Author(s)
八尋雄平, 前田真吾, 森川真大, 鯉沼代造, 篠原直弘, 河村一郎,石堂康弘, 影山龍一郎, 宮園浩平, 小宮節郎
Organizer
第17回運動器科学研究会
Place of Presentation
大阪大学中之島センター佐治敬三メモリアルホール・大阪リーガロイヤルホテル(大阪府・大阪市)
Year and Date
2016-09-02
Related Report
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[Presentation] Atoh8, a Direct Target Gene of BMP-Smad1/5/8 Signaling, Negatively Regulates Osteoblastic Bone Formation2016
Author(s)
Yuhei Hahiro, Shingo Maeda, Masato Morikawa, Daizo Koinuma, Naohiro Shinohara, Kanehiro Matsuyama, Ichiro Kawamura, Yasuhiro Ishidou, Ryoichiro Kageyama, Kohei Miyazono, Setsuro Komiya
Organizer
Orthopaedic Research Society Annual Meeting 2016
Place of Presentation
Orlando(USA)
Year and Date
2016-03-05
Related Report
Int'l Joint Research
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[Presentation] 新規BMPシグナル標的遺伝子Atoh8による骨芽細胞分化制御2016
Author(s)
八尋雄平, 前田真吾, 森川真大, 鯉沼代造, 篠原直弘, 松山金寛, 河村一郎, 石堂康弘, 影山龍一郎, 宮園浩平, 小宮節郎
Organizer
第29回 日本軟骨代謝学会
Place of Presentation
広島大学医学部(広島県 広島市)
Year and Date
2016-02-19
Related Report
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[Presentation] BMPシグナル標的遺伝子Atoh8による骨芽細胞分化抑制2015
Author(s)
八尋雄平, 前田真吾, 森川真大, 鯉沼代造, 篠原直弘, 松山金寛, 河村一郎, 横内雅博, 石堂康弘, 影山龍一郎, 宮園浩平, 小宮節郎
Organizer
第38回日本分子生物学会年会
Place of Presentation
神戸ポートアイランド(兵庫県 神戸市)
Year and Date
2015-12-01
Related Report
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[Presentation] BMPシグナル標的遺伝子Atoh8は骨芽細胞分化を抑制する2015
Author(s)
八尋雄平, 前田真吾, 森川真大, 鯉沼代造, 篠原直弘, 松山金寛, 河村一郎, 横内雅博, 石堂康弘, 影山龍一郎, 宮園浩平, 小宮節郎
Organizer
第16回運動器科学研究会
Place of Presentation
みなみホール(鹿児島県 鹿児島市)
Year and Date
2015-09-11
Related Report
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