Pathophysiological analysis of knee osteoarthritis targeted for synovium and its application for regulation of the disease
Project/Area Number |
15K10494
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | Juntendo University |
Principal Investigator |
ISHIJIMA Muneaki 順天堂大学, 医学(系)研究科(研究院), 准教授 (70365576)
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Co-Investigator(Renkei-kenkyūsha) |
KANEKO Kazuo 順天堂大学, 医学研究科, 教授 (50311981)
HIRASAWA Eri 順天堂大学, 医学研究科, 教授 (50245718)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 変形性膝関節症 / 痛み / 滑膜 / 骨棘 / 半月板逸脱 / パールカン / 高位脛骨骨切り術 / 人工膝関節置換術 / IL-6 / うつ状態 / 患者立脚型機能評価 / 軟骨下骨 / 半月板 / ADL / 骨髄異常陰影 / 滑膜炎 / 臨床症状 / 軟骨下骨陥凹 / 軟骨下骨嚢腫 |
Outline of Final Research Achievements |
We have examined the role of synovium for the pathophysiology of knee osteoarthritis (OA), while it has been mainly focused on the role of cartilage in this field. In the clinical research, we have revealed that synovitis, which is well corelated with clinical symptom of patients with knee OA, is associated with MRI-detected subchondral bone changes, but not cartilage damage, in patients with end-stage knee OA. We also have obtained by the basic research that perlecan in synovium plays a critical role for the regulation of Sox9 gene expression, which is a master gene for cartilage differentiation, in the synovial mesenchymal cells.
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Report
(4 results)
Research Products
(142 results)
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[Journal Article] Serum interleukin 6 levels are associated with depressive state of the patients with knee osteoarthritis irrespective of disease severity2017
Author(s)
Shimura Y, Kurosawa H, Tsuchiya M, Sawa M, Kaneko H, Liu L, Makino Y, Nojiri H, Iwase Y, Kaneko K, Ishijima M
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Journal Title
Clin Rheumatol
Volume: 36
Issue: 12
Pages: 2781-2787
DOI
Related Report
Peer Reviewed
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[Journal Article] MRI-evaluated osteophyte size is a risk factor for receiving the total knee arthroplasty in patients with end-stage knee osteoarthritis2017
Author(s)
Liu L, Ishijima M, Kaneko H, Sadatsuki R, Hada S, Kinoshita M, Futami I, Yusup A, Takazawa Y, Ikeda H, Kaneko K
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Journal Title
Mod Rheumatol
Volume: 27
Issue: 2
Pages: 332-38
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Association of medial meniscal extrusion with medial tibial osteophyte distance detected by T2 mapping MRI in the patients with eraly-stage knee osteoarthritis.2017
Author(s)
Hada S., Ishijima M., Kaneko H., Kinoshita M., Liu L., Sadatusuki R., Futami I., Yusup A., Takamura T., Arita H., Shiozawa J., Aoki T., Takazawa Y., Ikeda H., Aoki S., Kurosawa H., Okada Y. and Kaneko K.
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Journal Title
Arthritis Res Ther
Volume: 19
Issue: 1
Pages: 201-201
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Osteoarthritis as a cause of locomotive syndrome: Its influence on functional mobility and activities of daily living2017
Author(s)
Ishijima M, Kaneko H, Hada S, Kinoshita M, Sadatsuki R, Liu L, Shimura Y, Arita H, Shiozawa J, Yusup A, Futami I, Sakamoto Y, Ishibashi M, Machida S, Naito H, Arikawa-Hirasawa E, Hamada C, Saita Y, Takazawa Y, Ikeda H, Okada Y, Kaneko K
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Journal Title
Clinic Rev Bone Miner Metab
Volume: 14
Pages: 77-104
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Perlecan is required for the chondrogenic differentiation of synovial mesenchymal cells through regulation of Sox9 gene expression2017
Author(s)
Sadatsuki R, Kaneko H, Futami I, Kinoshita M, Nonaka R, Culley KL, Otero M, Hada S, Goldring MB, Yamada Y, Kaneko K, Arikawa-Hirasawa E, Ishijima M
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Journal Title
J Orthop Res
Volume: 35
Issue: 4
Pages: 837-46
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Sportology to prevent locomotive syndrome2016
Author(s)
Ishijima M, Kaneko H, Hada S, Kinoshita M, Ishibashi M, Sadatsuki R, Liu L, Arita H, Shiozawa J, Yusup A, Saita Y, Takazawa Y, Ikeda H, Arikawa-Hirasawa E, Okada Y, Kaneko K
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Journal Title
Juntendo Med J
Volume: 62, Supple 1
Pages: 44-49
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Kellgren-Lawrence分類からみた早期変形性膝関節症研究への期待と課題2016
Author(s)
石島旨章, 羽田晋之介, 金子晴香, 劉立足, 木下真由子, 有田均, 塩澤淳, アニユワルジャン・ユスプ 青木孝子, 高澤祐治, 池田浩, 岡田, 金子和夫
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Journal Title
Bone Joint Nerve
Volume: 6
Pages: 533-41
Related Report
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[Journal Article] MRIを用いた早期変形性膝関節症の病態解析2016
Author(s)
羽田晋之介, 石島旨章, 金子晴香, 劉立足, 木下真由子, 有田均, 塩澤淳, アニユワルジャン・ユスプ, 青木孝子, 高澤祐治, 池田浩, 岡田保典, 金子和夫
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Journal Title
Bone Joint Nerve
Volume: 6
Pages: 549-55
Related Report
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[Journal Article] 変形性膝関節症の疼痛と関連する病態2016
Author(s)
石島旨章, 金子晴香, 羽田晋之介, 劉立足, アヌワル・ジャン・ユユプ, 清村幸雄, 木下真由子, 有田均, 塩澤淳, 青木孝子, 長尾雅史, 高澤祐治, 池田浩, 岡田保典,金子和夫
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Journal Title
リウマチ科
Volume: 55
Pages: 632-40
Related Report
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[Journal Article] Bone marrow lesions, subchondral bone cysts and subchondral bone attrition are associated with histological synovitis in patients with end-stage knee osteoarthritis: A cross-sectional study2015
Author(s)
Yusup A, Kaneko H, Liu L, Ning L, Sadatsuki R, Hada S, Kamagata K, Kinoshita M, Futami I, Shimura Y, Tsuchiya M, Saita Y, Takazawa Y, Ikeda H, Aoki S, Kaneko K, Ishijima M
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Journal Title
Osteoarthritis Cartilage
Volume: 23
Pages: 1858-1864
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] The incidence of and risk factors for developing atypical femoral fractures in Japan2015
Author(s)
Saita Y, Ishijima, M, Mogami A, Baba T, Nagao M, Sakai K, Homma Y, Kato R, Miyagawa K, Nagura N, Wada T, Liu L, Obayashi O, Gen H, Kajihara H, Nozawa M, Shitoto K, Kaneko K
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Journal Title
J Bone Miner Metab
Volume: 33
Issue: 3
Pages: 311-318
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] A novel patient-reported outcome measure for anterior cruciate ligament injury: evaluating the reliability, validity, and responsiveness of Japanese anterior cruciate ligament questionnaire 252015
Author(s)
Nagao M, Doi T, Saita Y, Kobayashi Y, Kubota M, Kaneko H, Takazawa Y, Ishijima M, Kurosawa H, Kaneko K, Nozawa M, Ikeda H, Kim SG
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Journal Title
Knee Surg Sports Traumatol Arthrosc
Volume: April 17
Related Report
Peer Reviewed
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[Journal Article] 初期変形性膝関節症の病変進行の部位別差異2015
Author(s)
羽田晋之介, 石島旨章, 金子晴香, 劉立足, 定月亮, 木下真由子, アニュアルジャン・ユスプ,二見一平, 斎田良知, 高澤祐治, 池田浩, 金子和夫
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Journal Title
別冊整形外科 変形性膝関節症の診断と治療
Volume: 67
Pages: 8-12
Related Report
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[Journal Article] 変形性膝関節症の疼痛と進行におけるMRIの骨髄異常陰影の関連2015
Author(s)
定月亮, 石島旨章, 久保田光昭, 金子晴香, 羽田晋之介, 木下真由子, 劉立足, アニュアルジャン・ユスプ, 二見一平, 斎田良知, 高澤祐治, 池田浩, 黒澤尚, 金子和夫
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Journal Title
別冊整形外科 変形性膝関節症の診断と治療
Volume: 67
Pages: 18-22
Related Report
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[Journal Article] 末期変形性膝関節症における疼痛と滑膜炎そして炎症性サイトカインの発現パターンの連関性2015
Author(s)
劉立足, 石島旨章, 寧亮, 金子晴香, 定月亮, 羽田晋之介, 木下真由子, アニュアルジャン・ユスプ, 二見一平, 斎田良知, 高澤祐治, 池田浩, 黒澤尚, 金子和夫
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Journal Title
別冊整形外科 変形性膝関節症の診断と治療
Volume: 67
Pages: 23-29
Related Report
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[Journal Article] 変形性膝関節症の重症化に伴う疼痛影響因子の変化2015
Author(s)
清村幸雄, 石島旨章, 金子晴香, 定月亮, 羽田晋之介, 木下真由子, 劉立足, アニュアルジャン・ユスプ, 二見一平, 土屋勝, 斎田良知, 高澤祐治, 池田浩, 黒澤尚, 金子和夫
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Journal Title
別冊整形外科 変形性膝関節症の診断と治療
Volume: 67
Pages: 30-33
Related Report
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[Journal Article] 石島旨章, 内藤聖人, 渡泰士, 金子晴香, 劉立足, 定月亮, 羽田晋之介, 木下真由子, アニュアルジャン・ユスプ, 二見一平, 清村幸雄, 土屋勝, 斎田良知, 高澤祐治, 池田浩, 長岡功, 黒澤尚, 金子和夫2015
Author(s)
石島旨章, 内藤聖人, 渡泰士, 金子晴香, 劉立足, 定月亮, 羽田晋之介, 木下真由子, アニュアルジャン・ユスプ, 二見一平, 清村幸雄, 土屋勝, 斎田良知, 高澤祐治, 池田浩, 長岡功, 黒澤尚, 金子和夫
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Journal Title
別冊整形外科 変形性膝関節症の診断と治療
Volume: 67
Pages: 51-56
Related Report
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[Journal Article] 変形性膝関節症のバイオマーカー:血清ヒアルロン酸の臨床応用に向けたエビデンス2015
Author(s)
金子晴香, 石島旨章, 劉立足, 定月亮, 羽田晋之介, 木下真由子, アニュアルジャン・ユスプ, 二見一平, 斎田良知, 高澤祐治, 池田浩, 黒澤尚, 金子和夫
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Journal Title
別冊整形外科 変形性膝関節症の診断と治療
Volume: 67
Pages: 57-60
Related Report
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[Journal Article] 変形性膝関節症に対するヒアルロン酸関節内注射の有効性と安全性2015
Author(s)
石島旨章, 中村利孝, 清水克時, 林邦彦, 菊池啓, 宗圓聰, 大森豪, 山下敏彦, 内尾祐司, 千葉純司, 黒澤尚, 金子和夫
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Journal Title
別冊整形外科 変形性膝関節症の診断と治療
Volume: 67
Pages: 92-97
Related Report
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[Journal Article] 変形性膝関節症における運動療法の有効性と限界2015
Author(s)
石島旨章, 黒澤尚, 池田浩, 劉立足, 金子晴香, 定月亮, 羽田晋之介, 木下真由子, アニュワル・ユスプ, 斎田良知, 高澤祐治, 金子和夫
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Journal Title
別冊整形外科 変形性膝関節症の診断と治療
Volume: 67
Pages: 108-114
Related Report
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[Presentation] The degeneration of medial meniscus detected by T2 mapping MRI according to the severity of medial knee osteoarthritis2017
Author(s)
S. Hada, M. Ishijima, H. Kaneko, L. Liz, M. Kinoshita, H. Arita, J. Shiozawa, A. Yusup, Y. Takazawa, H. Ikeda, K. Kusunose, Y. Okada, K. Kaneko
Organizer
Osteoarthritis Reserce Society International (OARSI) 2017
Related Report
Int'l Joint Research
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[Presentation] Vitamin D status and index representing the detrimental mechanical loading across the knee joint in end-stage knee osteoarthritis2017
Author(s)
M Kinoshita, H Kaneko, M Ishijima, L Liu, R Sadatsuki, S Hada, A Yusup, H Arita, J Shiozawa, T Aoki,Y Tamura, R Kawamori, K Kaneko
Organizer
Ostevoarthritis Reserce Society International (OARSI) 2017
Related Report
Int'l Joint Research
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[Presentation] The lower ratio of the cartilage destruction and synthesis biomarkers is a risk for the radiographic medial knee joint space narrowing in men in early forties without knee osteoarthritis -A three years prospective observational study “Sportology Core Study 1”2017
Author(s)
Lizu Liu, Muneaki Ishijima, Haruka Kaneko, Ryo Sadatsuki, Shinnosuke Hada, Anwarjan Yusup, Mayuko Kinoshita, Hitoshi Arita, Jun Shiozawa, Takako Aoki, Masashi Nagao, Yuji Takazawa, Hiroshi Ikeda, Kazuo Kaneko
Organizer
Ostevoarthritis Reserce Society International (OARSI) 2017
Related Report
Int'l Joint Research
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[Presentation] The medial meniscus extrusion is inversely associated with the gait speed of the patients with end-stage of medial knee osteoarthritis2017
Author(s)
H Arita, H Kaneko, M Ishijima, M Ishibashi, L Liu, J Shiozawa, S Hada, M Kinoshita, A Yusup, T Aoki, M Nagao, Y Takazawa, H Ikeda, K Kaneko
Organizer
Ostevoarthritis Reserce Society International (OARSI) 2017
Related Report
Int'l Joint Research
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[Presentation] Pre-operative prevalence and risk factor for the asymptomatic deep vein thrombosis (DVT) in patients with end-stage knee osteoarthritis2017
Author(s)
Jun Shiozawa, Muneaki ishijima, Haruka Kaneko, Masataka Nagayama, Tetusro Miyazaki, Megumi Shimizu, Shinnosuke Hada, Mayuko Kinoshita, Hitoshi Arita, Lizu Liu, Masashi Nagao, Yuji Takazawa, Hiroshi Ikeda, Hiroyuki Daida, Kazuo Kaneko
Organizer
Ostevoarthritis Reserce Society International (OARSI) 2017
Related Report
Int'l Joint Research
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[Presentation] Medial meniscus extrusion was associated with the clinical manifestation of the elderlies aged 70’s without knee pain with Kellgren-Lawrence grade 2 of knee osteoarthritis (OA)2017
Author(s)
Takako Aoki, Lizu Liu, Muneaki Ishijima, Yuki Someya, Haruka Kaneko, Ryo Sadatsuki, Shinnosuke Hada, Anwarjan Yusup, Mayuko Kinoshita, Hitoshi Arita, Jun Shiozawa, Yoshifumi Tamura, Masashi Nagao, Yuji Takazawa, Hiroshi Ikeda, Hirotaka Watada, Ryuzo Kawamori, Kazuo Kaneko
Organizer
Ostevoarthritis Reserce Society International (OARSI) 2017
Related Report
Int'l Joint Research
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[Presentation] 末期内側型変形性膝関節症患者の歩行速度と内側半月板逸脱との関連2017
Author(s)
有田均,金子晴香,石島旨,石橋雅義,塩澤淳,劉立足,羽田晋之介,木下真由子,高澤祐治 ,池田浩,金子和夫
Organizer
第90回日本整形外科学会学術総会
Related Report
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[Presentation] 装着型小型歩行解析装置を用いた変形性膝関節症に対する術式別の歩行動態の検討2017
Author(s)
アニワルジャン・ユスプ, 石島旨章 ,金子晴香, 劉立足, 羽田晋之介, 木下真由子, 塩澤淳, 有田均, 高澤祐治, 池田浩, 金子和夫
Organizer
第90回日本整形外科学会学術総会
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[Presentation] 人工膝関節置換術後の疼痛及び臨床症状に影響を与える術後下肢アライメント指標のカットオフ値2017
Author(s)
劉立足, 石島旨章 ,金子晴香, 羽田晋之介, 木下真由子, アニワルジャン・ユスプ, 塩澤淳, 有田均, 高澤祐治, 池田浩, 金子和夫
Organizer
第90回日本整形外科学会学術総会
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[Presentation] 初期変形性膝関節症の内側半月板逸脱は脛骨内側の骨棘距離と相関する2017
Author(s)
羽田晋之介 ,石島旨章 金子晴香, 劉立足, Anwarjan Yusup, 木下真由子, 有田均, 塩澤淳, 青木孝子, 高澤祐治, 池田浩, 楠瀬浩一, 岡田保典, 金子和夫
Organizer
第90回日本整形外科学会学術総会
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[Presentation] 内側型変形膝関節症におけるX線重症度と内側半月板変性との関連2017
Author(s)
羽田晋之介,石島旨章, 金子晴香, 劉立足, Anwarjan Yusup, 木下真由子, 有田均, 塩澤淳, 青木孝子, 高澤祐治, 池田浩, 楠瀬浩一, 岡田保典, 金子和夫
Organizer
第90回日本整形外科学会学術総会
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[Presentation] 末期変形性膝関節症における無症候性深部静脈血栓症の保有率とリスク因子2017
Author(s)
塩澤淳, 石島旨章, 永山正隆, 金子晴香, 宮崎哲朗, 清水めぐみ, 劉立足, 高澤祐治, 池田浩,代田浩之, 金子和夫
Organizer
第90回日本整形外科学会学術総会
Related Report
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[Presentation] 装着型小型歩行解析装置を用いた変形性膝関節症に対する術式別の歩行動態の検討2017
Author(s)
金子晴香, 石島旨章, 有田均, 石橋雅義, 劉立足, 羽田晋之介, 木下真由子, 塩澤淳, 高澤祐治, 池田浩, 金子和夫
Organizer
第90回日本整形外科学会学術総会
Related Report
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[Presentation] Texture analysis using T2-Kurtosis Image of medial meniscus associated with meniscal pathologies2017
Author(s)
Aoki T, Ishijima M, Hada S, Kaneko H, Liu L, Kinoshita M, Arita H, Shiozawa J, Tamura Y, Watada H, Kaneko K
Organizer
10th International Workshop for Osteoarthritis Imaging
Related Report
Int'l Joint Research
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[Presentation] 初期変形性膝関節症患者の歩行速度と患者立脚型機能評価は相関する2017
Author(s)
有田均, 金子晴香, 石島旨章, 石橋雅義, 定月亮, 羽田晋之介, 木下真由子, 塩澤淳, 高澤祐治, 池田浩, 金子和夫
Organizer
第9回JOSKAS
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[Presentation] T2 mapping 法を用いた内側半月板変性と内側型変形膝関節症の単純X線重症度との関連2017
Author(s)
羽田晋之介 ,石島旨章, 金子晴香, 木下真由子, 有田均, 塩澤淳, 高澤祐治, 池田浩, 楠瀬浩一, 岡田保典, 金子和夫
Organizer
第9回JOSKAS
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[Presentation] 単純X線を用いた早期変形性膝関節症の診断2017
Author(s)
石島旨章, 金子晴香, 羽田晋之介, 有田均, 塩澤淳, 青木孝子, 長尾雅史, 高澤祐治, 池田浩, 斎田良知, 西尾啓史, 金子和夫
Organizer
第9回JOSKAS
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[Presentation] 壮年期男性の関節裂隙狭小化のリスク因子としての血清TRACP-5b -3年間の縦断研究2017
Author(s)
劉立足, 石島旨章 ,金子晴香, 木下真由子, 塩澤淳, 有田均, 青木孝子, 田村好史, 綿田裕孝, 高澤祐治, 池田浩, 金子和夫
Organizer
第35回日本骨代謝学会学術集会
Related Report
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[Presentation] ビタミンD充足状態と変形性膝関節症の骨棘の石灰化との関連2017
Author(s)
金子晴香, 石島旨章,, 羽田晋之介, 有田均, 劉立足, 木下真由子, 塩澤淳,青木孝子,長尾雅史, 齋田良知, 高澤祐治, 池田浩, 金子和夫
Organizer
第32回日本整形外科学会基礎学術集会
Related Report
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[Presentation] 変形性膝関節症の慢性疼痛と関連する滑膜炎と軟骨下骨病変そして滑膜のTGF-βシグナル活性化の関連(シンポジウム)2017
Author(s)
金子晴香, 石島旨章, アニワルジャン・ユスプ, 劉立足,有田均, 塩澤淳, 木下真由子, 羽田晋之介, 長尾雅史, 斎田良知, 高澤祐治, 池田浩, 金子和夫
Organizer
第32回日本整形外科学会基礎学術集会
Related Report
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[Presentation] 装着型小型歩行解析装置を用いた末期変形性関節症患者における人工関節置換術前後の階段昇降時の歩行動態の解析2017
Author(s)
有田均, 金子晴香, 石島旨章, 石橋雅義, 劉立足, 羽田晋之介, 木下真由子, 塩澤淳, 長尾雅史, 斎田良知, 高澤祐治, 池田浩, 金子和夫
Organizer
第32回日本整形外科学会基礎学術集会
Related Report
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[Presentation] 内側型変形性膝関節症における内側半月板逸脱と半月板形態の関連2017
Author(s)
羽田晋之介 ,石島旨章, 金子晴香, 木下真由子, 有田均 , 塩澤淳 , 高澤祐治, 池田浩, 楠瀬浩一, 岡田保典, 金子和夫
Organizer
第32回日本整形外科学会基礎学術集会
Related Report
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[Presentation] 初期変形性膝関節症において内側半月板逸脱は内側脛骨側骨棘と関連する2017
Author(s)
羽田晋之介 ,石島旨章, 金子晴香, 木下真由子, 有田均 , 塩澤淳, 高澤祐治, 池田浩, 楠瀬浩一, 岡田保典, 金子和夫
Organizer
第32回日本整形外科学会基礎学術集会
Related Report
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[Presentation] 末期変形性膝関節症患者の臨床症状と歩行動態は患側の歩行時中心足底圧と相関する2016
Author(s)
18.有田均, 石島旨章, 金子晴香, 石橋雅義, 羽田晋之介, 木下真由子, 定月亮, 劉立足, 塩澤淳 ,アニワルジャン・ユスプ, 高澤祐治, 池田浩, 金子和夫
Organizer
第31回日本整形外科学会基礎学術集会
Place of Presentation
福岡
Year and Date
2016-10-13
Related Report
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[Presentation] 壮年期変形性膝関節症発症前膝関節裂隙狭小化と軟骨代謝動態との関連-3年間の縦断研究2016
Author(s)
木下真由子, 石島旨章, 金子晴香, 劉立足, 定月亮, 羽田晋之介, アニワルジャン ユスプ, 塩澤淳, 有田均, 田村好史, 綿田裕孝, 河盛隆三, 金子和夫
Organizer
第31回日本整形外科学会基礎学術集会
Place of Presentation
福岡
Year and Date
2016-10-13
Related Report
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[Presentation] パールカンによる滑膜間葉系細胞からの軟骨分化制御2016
Author(s)
木下真由子, 金子晴香, 石島旨章, 定月亮, 二見一平, 羽田晋之介, 有田均, 塩澤淳, 平澤恵理, 山田吉彦, 金子和夫
Organizer
第31回日本整形外科学会基礎学術集会
Place of Presentation
福岡
Year and Date
2016-10-13
Related Report
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[Presentation] 変形性膝関節症の初期変化としての骨棘は内軟骨性骨化に類似した過程を経て形成されMRI・T2マッピング法にて正確に評価可能となる2016
Author(s)
羽田晋之介, 石島旨章, 金子晴香, 劉立足, 木下真由子, 有田均, 塩澤淳, Anwarjan Yusup, 高澤祐治, 池田浩, 岡田保典, 金子和夫
Organizer
第31回日本整形外科学会基礎学術集会
Place of Presentation
福岡
Year and Date
2016-10-13
Related Report
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[Presentation] 人工膝関節置換術後の疼痛及び臨床症状に影響を与える術後下肢アライメント指標のカットオフ値2016
Author(s)
劉立足, 石島旨章, 金子晴香, 羽田晋之介, 木下真由子, アニワルユスプ, 塩澤淳, 有田均, 高澤祐治, 池田浩, 金子和夫
Organizer
第34回日本骨代謝学会
Place of Presentation
大阪
Year and Date
2016-07-20
Related Report
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[Presentation] 末期変形性膝関節症の滑膜炎と軟骨下骨病変は相関する2016
Author(s)
Yusup A, Ishijima M, Kaneko H, Liu L, Sadatsuki R, Hada S, Kinoshita S, Arita H, Shiozawa J, Futami I, Shimura Y, Kamagata K, Saita Y, Takazawa Y, Ikeda Y, Kaneko K
Organizer
第34回日本骨代謝学会
Place of Presentation
大阪
Year and Date
2016-07-20
Related Report
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[Presentation] Medial meniscal extrusion is associated with medial tibial osteophyte development and the degeneration of medial meniscus in early-stage of knee osteoartheitis2016
Author(s)
Hada S, Ishijima M, Kaneko H, Liu L, Kinoshita M, Arita H, Shiozawa J, Anwarjan Y, Takazawa Y, Ikeda H, Okada Y, Kaneko K
Organizer
2016 IWOAI
Place of Presentation
Oulu, Finland
Year and Date
2016-06-15
Related Report
Int'l Joint Research
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[Presentation] 小型歩行解析装置による変形性膝関節症に対する術前後の歩行解析2016
Author(s)
金子晴香, 石島旨章, 石橋雅義, 有田均, 劉立足, 定月亮, 羽田晋之介, 木下真由子, 高澤祐治, 池田浩, 金子和夫
Organizer
第89回日本整形外科学会学術総会
Place of Presentation
横浜
Year and Date
2016-05-12
Related Report
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[Presentation] 初期内側型変形膝関節症における内側半月板側方偏位と内側半月板変性との関連2016
Author(s)
羽田晋之介, 石島旨章, 金子晴香, 劉立足, アニワルジャンユスプ, 木下真由子, 有田均, 塩澤淳, 高澤祐治, 池田浩, 金子和夫
Organizer
第89回日本整形外科学会学術総会
Place of Presentation
横浜
Year and Date
2016-05-12
Related Report
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[Presentation] 内側型変形性膝関節症の臨床症状は膝内反化にて増強する2016
Author(s)
清村幸雄, 黒澤尚, 石島旨章, 劉立足, 金子晴香, 土屋勝, 定月亮, 羽田晋之介, 木下真由子, 岩瀬嘉志, 金子和夫
Organizer
第89回日本整形外科学会学術総会
Place of Presentation
横浜
Year and Date
2016-05-12
Related Report
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[Presentation] TKA術後深部静脈血栓症発生患者では血清アラキドン酸(AA)高値及びEPA/AA比低値である2016
Author(s)
塩澤淳, 金子晴香, 永山正隆, 宮崎哲朗, 比企優, 石島旨章,羽田晋之介, 木下真由子, 劉立足,代田浩之,金子和夫
Organizer
第89回日本整形外科学会学術総会
Place of Presentation
横浜
Year and Date
2016-05-12
Related Report
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[Presentation] The variations for the recovery processes of the several parameters those monitor the walking ability in patients with end-stage knee osteoarthritis using a novel motion capture devices2016
Author(s)
Kaneko H, Ishibashi M, Arita H, Liu L, Sadatsuki R, Hada S, Kinoshita M, Yusup A, Shiozawa S, Takazawa Y, Ikeda H, Kaneko K, Ishijima M
Organizer
Osteoarthritis Research Society International (OARSI) 2016
Place of Presentation
Amsterdam, Netherland
Year and Date
2016-04-01
Related Report
Int'l Joint Research
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[Presentation] Association between the degeneration and medial radial displacement of the medial meniscus on T2 mapping at 3T MRI in patients with early-stage knee osteoarthritis2016
Author(s)
Hada S, Ishijima M, Kaneko H, Sadatsuki R, Liz L, Kinoshita M, Arita H, Shiozawa J, Yusup Y, Takazawa Y, Ikeda H, Kaneko K
Organizer
Osteoarthritis Research Society International (OARSI) 2016
Place of Presentation
Amsterdam, Netherland
Year and Date
2016-04-01
Related Report
Int'l Joint Research
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[Presentation] Perlecan regulates chondrogenic differentiation from synovial mesenchymal cells via Smad and MAPK signaling pathways2016
Author(s)
Kinoshita M, Kaneko H, Sadatsuki R, Futami I, Hada S, Arita H, Shiozawa J, Hirasawa-Arikawa E, Yamada Y, Kaneko K, Ishijima M
Organizer
Osteoarthritis Research Society International (OARSI) 2016
Place of Presentation
Amsterdam, Netherland
Year and Date
2016-04-01
Related Report
Int'l Joint Research
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[Presentation] Higher bone turnover detected by serum levels of tartrate-resistant acid phosphatase 5b (TRACP-5b) is a risk for the radiographic medial knee joint space narrowing in men in early forties without knee pain -the three years prospective observational study2016
Author(s)
Liu L, Kaneko H, Sadatsuki R, Hada S, Yusup A, Kinoshita M, Arita H, Shiozawa J, Y Saita, Takazawa Y, Ikeda H, Kaneko K, Ishijima M
Organizer
Osteoarthritis Research Society International (OARSI) 2016
Place of Presentation
Amsterdam, Netherland
Year and Date
2016-04-01
Related Report
Int'l Joint Research
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[Presentation] Association between the histological synovitis, subchondral pathologies and synovial TGF-β/Smad signaling in patient with end-stage knee osteoarthritis2016
Author(s)
Yusup A, Kaneko H, Liu L Hada S, Kinoshita M, Arita H, Shiozawa J, Saita Y, Takazawa Y, Ikeda H, Kaneko K, Ishijima M
Organizer
Osteoarthritis Research Society International (OARSI) 2016
Place of Presentation
Amsterdam, Netherland
Year and Date
2016-04-01
Related Report
Int'l Joint Research
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[Presentation] Serum polyunsaturated fatty acid (PUFAs) levels as a risk factor for the post-operative development of venous thromboembolism (VTE) in patients with end-stage knee osteoarthritis who receiving total knee arthroplasty (TKA)2016
Author(s)
Shiozawa J,Miyazaki T, Nagayama M, Kaneko H, Hiki M, Hada S, Kinoshita M, Liu L, Arita H, Saita Y, Takazawa Y, Ikeda H, Daida H, Kaneko K, Ishijima M
Organizer
Osteoarthritis Research Society International (OARSI) 2016
Place of Presentation
Amsterdam, Netherland
Year and Date
2016-04-01
Related Report
Int'l Joint Research
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[Presentation] 壮年期の初期変形性膝関節症性変化と軟骨代謝状態の関連2015
Author(s)
木下真由子, 石島旨章, 金子晴香, 劉立足,定月亮, 羽田晋之介, アニワルジャン・ユスプ, 高澤祐治, 池田浩, 田村好史, 綿田裕孝, 河盛隆三, 金子和夫
Organizer
第30回日本整形外科学会基礎学術集会
Place of Presentation
富山
Year and Date
2015-10-22
Related Report
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[Presentation] 末期変形性膝関節症の膝周囲骨変形とビタミンD充足状態との関連2015
Author(s)
金子晴香, 石島旨章, 定月亮, 劉立足, 羽田晋之介, 木下真由子, 小林洋平, 齋田良知, 高澤祐治, 池田浩, 金子和夫
Organizer
第7回JOSKAS
Place of Presentation
札幌
Year and Date
2015-06-18
Related Report
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[Presentation] 初期変形性膝関節症の半月板逸脱と軟骨摩耗および骨棘形成の関連2015
Author(s)
羽田晋之介 ,石島旨章, 金子晴香, 劉立足, 定月亮, 木下真由子, Anwarjan Yusup, 斎田良知, 高澤祐治, 池田浩, 金子和夫
Organizer
第7回JOSKAS
Place of Presentation
札幌
Year and Date
2015-06-18
Related Report
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[Presentation] 変形性膝関節症術前後の歩行解析を可能とした新規小型歩行解析装置の開発2015
Author(s)
金子晴香, 石島旨章, 石橋雅義, 定月亮, 羽田晋之介, 劉立足, 木下真由子, Anwarjan Yusup, 高澤祐治, 池田浩, 金子和夫
Organizer
第88回日本整形外科学会学術総会
Place of Presentation
神戸
Year and Date
2015-05-21
Related Report
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[Presentation] MRIによる軟骨病変は初期膝OAの進行関連因子である2015
Author(s)
定月亮, 石島旨章, 金子晴香, 劉立足, 羽田晋之介, 木下真由子, Anwarjan Yusup, 斎田良知, 高澤祐治, 池田浩, 金子和夫
Organizer
第88回日本整形外科学会学術総会
Place of Presentation
神戸
Year and Date
2015-05-21
Related Report
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[Presentation] 変形性膝関節症患者の抑うつは滑膜炎と関連する:横断研究2015
Author(s)
清村幸雄, 黒澤尚, 石島旨章, 土屋勝, 金子晴香, 定月亮, 劉立足, 牧野祐司, 澤満美子, 岩瀬嘉志, 金子和夫
Organizer
第88回日本整形外科学会学術総会
Place of Presentation
神戸
Year and Date
2015-05-21
Related Report
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[Presentation] 変形性膝関節症患者における抑うつ状態の影響因子2015
Author(s)
土屋勝, 黒澤尚, 石島旨章, 金子晴香, 定月亮, 清村幸雄, 牧野祐司, 澤満美子, 野尻英俊, 岩瀬嘉志, 金子和夫
Organizer
第88回日本整形外科学会学術総会
Place of Presentation
神戸
Year and Date
2015-05-21
Related Report
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[Presentation] The lower cartilage synthesis, but not higher cartilage destruction, is associated with the knee joint space width in men in earkly forties without knee pain2015
Author(s)
Kinoshita M, Kaneko H, Liu L, Sadatsuki R, Hada S, Shimura Y, Tsuchiya M, Yusup A, Futami I, Tamura Y, Watada H, R Kawamori, Kaneko K, Ishijima M
Organizer
Osteoarthritis Research Society International (OARSI) 2015
Place of Presentation
シアトル
Year and Date
2015-04-30
Related Report
Int'l Joint Research
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[Presentation] Development of a novel miniaturized motion capture technology to assess gait of outpatients with knee osteoarthritis in the clinical setting2015
Author(s)
Kaneko H, Ishijima M, Ishibashi M, Sadatsuki R, Hada S, Kinoshita M, Liu L, Yusup A, Kobayashi Y, Saita Y, Takazawa Y, Ikeda H, Kaneko K
Organizer
Osteoarthritis Research Society International (OARSI) 2015
Place of Presentation
シアトル
Year and Date
2015-04-30
Related Report
Int'l Joint Research
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[Presentation] The site-specific associations between the meniscus changes and the osteophyte formations in early-stage knee osteoarthritis2015
Author(s)
Hada S, Kaneko H, Sadatsuki R, Liu L, Yusup A, Kinoshita M, Futami I, Shimura Y, Tsuchiya T, Saita Y, Takazawa Y, Ikeda H, Kaneko K, Ishijima M
Organizer
Osteoarthritis Research Society International (OARSI) 2015
Place of Presentation
シアトル
Year and Date
2015-04-30
Related Report
Int'l Joint Research
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[Presentation] Bone marrow lesions are associated with local histological synovitis in patients with end-stage knee osteoarthritis: A cross-sectional study2015
Author(s)
Yusup A, Kaneko H, Liu L, Ning L, Sadatsuki R, Hada S, Kinoshita M, Futami I, Shimura Y, Tsuchiya T, Saita Y, Takazawa Y, Ikeda H, Kaneko K, Ishijima M
Organizer
Osteoarthritis Research Society International (OARSI) 2015
Place of Presentation
シアトル
Year and Date
2015-04-30
Related Report
Int'l Joint Research
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[Presentation] Medial cartilage lesions detected by 3.0-Tesla MRI are the risk factor for the progression of early-stage medial knee osteoarthritis2015
Author(s)
Sadatsuki R, Kaneko H, Hada S, Kinoshita M, Liu L, Yusup A, Kobayashi Y, Saita Y, Takazawa Y, Ikeda H, Kaneko K, Ishijima M
Organizer
Osteoarthritis Research Society International (OARSI) 2015
Place of Presentation
シアトル
Year and Date
2015-04-30
Related Report
Int'l Joint Research
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[Presentation] The influential factors for the depressive state in patients with knee osteoarthritis2015
Author(s)
Tsuchiya M, Kurosawa H, Shimura Y, Kaneko H, Liz L, Sadatsuki R, Yusup A, Hada S, Kinoshita M, Makino Y, Sawa M, Iwase Y, Kaneko K, Ishijima M
Organizer
Osteoarthritis Research Society International (OARSI) 2015
Place of Presentation
シアトル
Year and Date
2015-04-30
Related Report
Int'l Joint Research
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[Presentation] The exercise therapy decreases the serum interleukin-6 levels in patients with knee OA2015
Author(s)
Shimura Y, Kurosawa H, Tsuchiya M, Kaneko H, Liu L, Sadatsuki R, Hada S, Kinoshita M, Yusup A, Kaneko K, Ishijima M
Organizer
Osteoarthritis Research Society International (OARSI) 2015
Place of Presentation
シアトル
Year and Date
2015-04-30
Related Report
Int'l Joint Research
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[Presentation] Postoperative mechanical alignment of the lower limb corresponding to the successful clinical outcome after total knee arthroplasty (TKA)2015
Author(s)
Liu L, Kaneko H, Kurosawa H, Sadatsuki R, Hada S, Kinoshita M, Yusup A, Shimura Y, Tsuchiya T, Futami I, Kobayashi Y, Saita Y, Takazawa Y, Ikeda H, Kaneko K, Ishijima M
Organizer
Osteoarthritis Research Society International (OARSI) 2015
Place of Presentation
シアトル
Year and Date
2015-04-30
Related Report
Int'l Joint Research
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