| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Outline of Final Research Achievements |
This investigation revealed that skeletal loading or unloading induced un-coupling of bone formation and
bone resorption. Under the unloading condition, osteoclasts were activated and calcitonin receptors were highly expressed in osteoclasts, while under the loading condition or disruption of aldehyde dehydrogenase 2 gene, osteoblasts were activated and parathyroid hormone receptors were highly expressed in osteoblasts and osteocytes. Our studies demonstrated that signal through calcitonin receptor in osteoclasts under the unloading condition and signal through parathyroid hormone receptor in osteoblasts and osteocytes under the loading condition were important for regulatory mechanism for bone adaption of mechanical alteration.
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