Elucidation of molecular regulatory mechanism of communication between bone constituent cells under skeletal loading

• Project/Area Number: 15K10499
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: Sakai Akinori 産業医科大学, 医学部, 教授 (90248576)
• Project Period (FY): 2015-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: メカニカルストレス / カルシトニン / 副甲状腺ホルモン / 海綿骨 / 皮質骨 / アルデヒド脱水素酵素 / マウス / 骨形態計測 / 副甲状腺ホルモン受容体 / 非荷重 / 骨細胞 / 骨粗鬆症 / アセトアルデヒド脱水素酵素 / 二次海綿骨 / 破骨細胞 / TRACP / 骨髄細胞 / カルシトニン受容体 / スクレロスチン / RANKL / カテプシンK / 骨芽細胞 / 海綿骨量

Outline of Final Research Achievements

This investigation revealed that skeletal loading or unloading induced un-coupling of bone formation and
bone resorption. Under the unloading condition, osteoclasts were activated and calcitonin receptors were highly expressed in osteoclasts, while under the loading condition or disruption of aldehyde dehydrogenase 2 gene, osteoblasts were activated and parathyroid hormone receptors were highly expressed in osteoblasts and osteocytes. Our studies demonstrated that signal through calcitonin receptor in osteoclasts under the unloading condition and signal through parathyroid hormone receptor in osteoblasts and osteocytes under the loading condition were important for regulatory mechanism for bone adaption of mechanical alteration.

Academic Significance and Societal Importance of the Research Achievements

長期間の臥床や宇宙空間での滞在などの非荷重環境や運動などの荷重環境では、骨芽細胞による骨形成と破骨細胞による骨吸収は連動せずに、個別の変化を示す。本研究課題ではその病態を解明した。非荷重状態では破骨細胞におけるカルシトニン受容体の発現が亢進しその受容体を介したシグナルが、また、荷重負荷状態やアルデヒド脱水素酵素遺伝子欠損状態では骨芽細胞と骨細胞における副甲状ホルモン受容体の発現が亢進しその受容体を介したシグナルが、それぞれ重要である。これらの受容体を介したシグナルを調節することで、非荷重による骨量減少を抑制し、荷重による骨量増加を促進することをさらに効率的にできる可能性がある。

Research Products

• [Journal Article] Acetaldehyde dehydrogenase 2 deficiency increases mitochondrial reactive oxygen species emission and induces mitochondrial protease Omi/HtrA2 in skeletal muscle. (2020)
  • Author(s): Wakabayashi Y, Tamura Y, Kouzaki K, Kikuchi N, Hiranuma K, Menuki K, Tajima T, Yamanaka Y, Sakai A, Nakayama KI, Kawamoto T, Kitagawa K, Nakazato K.
  • Journal Title: Am. J. Physiol. Regul. Integr. Comp. Physiol. Volume: 318 Issue: 4 Pages: 677-690
  • DOI: 10.1152/ajpregu.00089.2019
  • NAID: 120007089104
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Skeletal unloading reduces cluster of differentiation (CD) 38 expression in the bone marrow and osteoblasts of mice. (2020)
  • Author(s): Moridera K, Uchida S, Tanaka S, Menuki K, Utsunomiya H, Yamaoka K, Sonomoto K, Tanaka Y, Sakai A
  • Journal Title: J Orthop Sci Volume: 25 Issue: 2 Pages: 331-337
  • DOI: 10.1016/j.jos.2019.03.023
  • Peer Reviewed / Open Access
• [Journal Article] 連載 卒後研修講座 新しい骨代謝制御法による骨粗鬆症治療 (2018)
  • Author(s): 酒井 昭典
  • Journal Title: 整形外科 Volume: 69 Issue: 1 Pages: 61-67
  • DOI: 10.15106/j_seikei69_61
  • ISSN: 0030-5901, 2432-9444
  • Year and Date: 2018-01-01
  • Peer Reviewed
• [Journal Article] Cortical bone loss due to skeletal unloading in aldehyde dehydrogenase 2 gene knockout mice is associated with decreased PTH receptor expression in osteocytes. (2018)
  • Author(s): Tajima Takafumi, Menuki Kunitaka, Okuma Kayoko Furukawa, Tsukamoto Manabu, Fukuda Hokuto, Okada Yasuaki, Kosugi Kenji, Yamanaka Yoshiaki, Uchida Soshi, Sakai Akinori
  • Journal Title: Bone Volume: 110 Pages: 254-266
  • DOI: 10.1016/j.bone.2018.02.020
  • Peer Reviewed
• [Journal Article] Influence on the bone mineral density and bone metabolism marker after the interruption and reinitiation of monthly minodronate therapy in postmenopausal women with osteoporosis. (2018)
  • Author(s): Okimoto Nobukazu, Arita Shinobu, Akahoshi Shoji, Baba Kenji, Fukuhara Shito, Ishikura Toru, Yoshioka Toru, Fuse Yoshifumi, Okamoto Ken, Menuki Kunitaka, Sakai Akinori
  • Journal Title: Osteoporos Sarcopenia Volume: 4 Issue: 2 Pages: 61-68
  • DOI: 10.1016/j.afos.2018.05.001
  • Peer Reviewed / Open Access
• [Journal Article] Synovial mesenchymal stem cells derived from the cotyloid fossa synovium have higher self-renewal and differentiation potential than those from the paralabral synovium in the hip joint. (2018)
  • Author(s): Murata Yoichi, Uchida Soshi, Utsunomiya Hajime, Hatakeyama Akihisa, Nakashima Hirotaka, Chang Angela, Sekiya Ichiro, Sakai Akinori
  • Journal Title: American Journal of Sports Medicine Volume: 46 Issue: 12 Pages: 2942-2953
  • DOI: 10.1177/0363546518794664
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 特集 骨リモデリング制御と疾患 Seminar 不動化と骨リモデリング異常 (2017)
  • Author(s): 塚本学、酒井昭典
  • Journal Title: CLINICAL CALCIUM Volume: 27 Issue: 12 Pages: 1723-1730
  • DOI: 10.20837/4201712049
  • ISSN: 0917-5857
  • Year and Date: 2017-11-28
• [Journal Article] 特集 非定型大腿骨骨折の病態と治療 非定型大腿骨骨折のリスク因子多施設共同研究症例の解析を中心に (2017)
  • Author(s): 善家 雄吉、池田 聡、福田 文雄、田中 正宏、平野 文崇、酒井 昭典
  • Journal Title: 整形･災害外科 Volume: 60 Issue: 8 Pages: 959-964
  • DOI: 10.18888/se.0000000078
  • ISSN: 0387-4095
  • Year and Date: 2017-07-01
  • Peer Reviewed
• [Journal Article] Disruption of the Aldehyde Dehydrogenase 2 Gene Results in No Increase in Trabecular Bone Mass Due to Skeletal Loading in Association with Impaired Cell Cycle Regulation Through p21 Expression in the Bone Marrow Cells of Mice (2017)
  • Author(s): Okuma Kayoko Furukawa、Menuki Kunitaka、Tsukamoto Manabu、Tajima Takafumi、Fukuda Hokuto、Okada Yasuaki、Mori Toshiharu、Tsuchiya Takuto、Kawamoto Toshihiro、Yoshida Yasuhiro、Uchida Soshi、Sakai Akinori
  • Journal Title: Calcified Tissue International Volume: 101 Issue: 3 Pages: 328-340
  • DOI: 10.1007/s00223-017-0285-0
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of the induction of c- fos -eGFP and Fos protein in the rat spinal cord and hypothalamus resulting from subcutaneous capsaicin or formalin injection (2017)
  • Author(s): Motojima Yasuhito、Matsuura Takanori、Yoshimura Mitsuhiro、Hashimoto Hirofumi、Saito Reiko、Ueno Hiromichi、Maruyama Takashi、Sonoda Satomi、Suzuki Hitoshi、Kawasaki Makoto、Ohnishi Hideo、Sakai Akinori、Ueta Yoichi
  • Journal Title: Neuroscience Volume: 356 Pages: 64-77
  • DOI: 10.1016/j.neuroscience.2017.05.015
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Survey of hip fractures in Japan: Recent trends in prevalence and treatment (2017)
  • Author(s): Hagino Hiroshi、Endo Naoto、Harada Atsushi、Iwamoto Jun、Mashiba Tasuku、Mori Satoshi、Ohtori Seiji、Sakai Akinori、Takada Junichi、Yamamoto Tetsuji
  • Journal Title: Journal of Orthopaedic Science Volume: 22 Issue: 5 Pages: 909-914
  • DOI: 10.1016/j.jos.2017.06.003
  • Peer Reviewed / Open Access
• [Journal Article] 新規骨粗鬆症治療 (2017)
  • Author(s): 酒井 昭典
  • Journal Title: 日本骨粗鬆症学会雑誌 Volume: 3 Pages: 35-39
  • Peer Reviewed
• [Journal Article] Isolation and characterization of synovial mesenchymal stem cell derived from hip joints: a comparative analysis with a matched control knee group (2017)
  • Author(s): Akihisa Hatakeyama, Soshi Uchida, Hajime Utsunomiya, Manabu Tsukamoto, Hirotaka Nakashima, Eiichiro Nakamura, Cecilia Pascual-Garrido, Ichiro Sekiya, Akinori Sakai
  • Journal Title: Stem Cells International Volume: 2017 Pages: 9312329-9312329
  • DOI: 10.1155/2017/9312329
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Spontaneous differentiation of human mesenchymal stem cells on poly-lactic-co-glycolic acid nano-fiber scaffold (2016)
  • Author(s): Koshiro Sonomoto, Kunihiro Yamaoka, Hiroaki Kaneko, Kaoru Yamagata, Kei Sakata, Xiangmei Zhang, Masahiro Kondo, Yukichi Zenke, Ken Sabanai, Shingo Nakayamada, Akinori Sakai, Yoshiya Tanaka
  • Journal Title: PLOS ONE Volume: in press Issue: 4 Pages: e0153231-e0153231
  • DOI: 10.1371/journal.pone.0153231
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 疲労骨折のバイオメカニクス (2016)
  • Author(s): 酒井昭典、池田聡、善家雄吉、目貫邦隆、平澤英幸、田島貴文
  • Journal Title: 整形・災害外科 Volume: 59 Pages: 1395-1402
  • Peer Reviewed
• [Journal Article] Study of Atypical Femoral Fracture Cases Coupled in a Multicenter Study (2016)
  • Author(s): Yukichi Zenke, Satoshi Ikeda, Fumio Fukuda, Masahiro Tanaka, Hidetoshi Tanaka, Fumitaka Hirano, Akinori Sakai
  • Journal Title: Journal of UOEH Volume: 38 Issue: 3 Pages: 207-214
  • DOI: 10.7888/juoeh.38.207
  • NAID: 130005410869
  • ISSN: 0387-821X, 2187-2864
  • Peer Reviewed / Open Access
• [Journal Article] Osteoclasts are not activated in middle ear cholesteatoma. (2016)
  • Author(s): Koizumi H, Suzuki H, Ikezaki S, Ohbuchi T, Hashida K, Sakai A
  • Journal Title: J Bone Miner Metab Volume: 34 Issue: 2 Pages: 193-200
  • DOI: 10.1007/s00774-015-0655-5
  • Peer Reviewed
• [Journal Article] Elcatonin prevents bone loss caused by skeletal unloading by inhibiting preosetoclast fusion through the unloading-induced high expression of calcitonin receptors in bone marrow cells. (2016)
  • Author(s): Tsukamoto M, Menuki K, Murai T, Hatakeyama A, Takada S, Furukawa K, Sakai A
  • Journal Title: Bone Volume: 85 Pages: 70-80
  • DOI: 10.1016/j.bone.2016.01.025
  • Peer Reviewed
• [Journal Article] 保存治療を行った橈骨遠位端骨折におけるX線パラメータの経時的変化の検討 (2016)
  • Author(s): 古川佳世子、善家雄吉、目貫邦隆、平澤英幸、酒井昭典、古川英樹
  • Journal Title: 日手会誌 Volume: 32 Pages: 535-538
  • Peer Reviewed
• [Journal Article] ビスホスホネート薬 (2016)
  • Author(s): 目貫邦隆、酒井昭典
  • Journal Title: medicina Volume: 53 Pages: 500-502
• [Journal Article] Efficacy of combined treatment with alendronate (ALN) and eldecalcitol, a new active vitamin D analog, compared to that of concomitant ALN, vitamin D plus calcium treatment in Japanese patients with primary osteoporosis. (2015)
  • Author(s): Sakai A, Ito M, Tomomitsu T, Tsurukami H, Ikeda S, Fukuda F, Mizunuma H, Inoue T, Saito H, Nakamura T
  • Journal Title: Osteoporos Int Volume: 26 Issue: 3 Pages: 1193-1202
  • DOI: 10.1007/s00198-014-2991-z
  • Peer Reviewed / Open Access
• [Journal Article] 多施設共同研究による非定型大腿骨骨折症例の検討 (2015)
  • Author(s): 善家雄吉、酒井昭典、池田聡、田中秀敏、福田文雄、田中正宏
  • Journal Title: 骨折 Volume: 37 Pages: 5-9
  • Peer Reviewed
• [Journal Article] 骨吸収抑制薬の薬理学 (2015)
  • Author(s): 目貫邦隆、酒井昭典
  • Journal Title: 日本臨床 Volume: 73 Pages: 1634-1638
• [Journal Article] 服薬継続率の向上には利便性に基づいた剤形選択が重要 (2015)
  • Author(s): 酒井昭典
  • Journal Title: Clinic Magazine Volume: 558 Pages: 9-13
• [Presentation] 上肢骨折の治療と二次骨折予防への取り組み (2019)
  • Author(s): 酒井昭典、善家雄吉、山中芳亮、田島貴文、岡田祥明、小杉健二、池田聡
  • Organizer: 第21回日本骨粗鬆症学会
  • Invited
• [Presentation] 荷重と骨量・骨構造 (2019)
  • Author(s): 酒井昭典、山中芳亮、塚本学、田島貴文、岡田祥明、小杉健二
  • Organizer: 第37回日本骨代謝学会学術集会
  • Invited
• [Presentation] 健康寿命の延伸として骨粗鬆症対策は重要である (2019)
  • Author(s): 酒井昭典
  • Organizer: 第6回日本予防理学療法学会学術大会
  • Invited
• [Presentation] Disruption of the aldehyde dehydrogenase 2 gene increases bone anabolic response to intermittent PTH treatment in ovariectomized mice model. (2019)
  • Author(s): Kenji Kosugi, Takafumi Tajima, Kayoko Okuma, Yasuaki Okada, Manabu Tsukamoto, Yoshiaki Yamanaka, Kunitaka Menuki, Akinori Sakai
  • Organizer: The American Society for Bone and Mineral Research 2019 Annual Meeting
  • Int'l Joint Research
• [Presentation] Disruption of aldehyde dehydrogenase 2 gene accelerates articular cartilage degeneration in osteoarthritis induced by mechanical loading in mice. (2019)
  • Author(s): Yasuaki Okada, Yoshiaki Yamanaka, Kenji Kosugi, Kayoko Okuma, Takafumi Tajima, Manabu Tsukamoto, Kunitaka Menuki, Akinori Sakai
  • Organizer: The American Society for Bone and Mineral Research 2019 Annual Meeting
  • Int'l Joint Research
• [Presentation] Distal radius fractures and osteoporosis (2018)
  • Author(s): Sakai Akinori
  • Organizer: The 6th Seoul Symposium on Bone Health
  • Int'l Joint Research / Invited
• [Presentation] 高齢者の橈骨遠位端骨折に対する手術とその後の骨粗鬆症治療 (2018)
  • Author(s): 酒井昭典
  • Organizer: 第91回日本整形外科学会学術総会
  • Invited
• [Presentation] 骨粗鬆症治療におけるビタミンDの重要性 (2018)
  • Author(s): 酒井昭典
  • Organizer: 第60回日本老年医学会学術総会
  • Invited
• [Presentation] 骨粗鬆症の薬物治療 (2018)
  • Author(s): 酒井昭典
  • Organizer: 第36回日本骨代謝学会学術集会
  • Invited
• [Presentation] Effectiveness of intravenous ibandronate on bone mineral density in patient with osteoporosis treated with oral bisphosphonate low responders -MOVEMENT Study- (2018)
  • Author(s): Hagino Hiroshi, Sakai Akinori, Ikeda Satoshi, Imanishi Yasuo, Tsurukami Hiroshi, Nakajo Satoru, Miyakoshi Naohisa
  • Organizer: American Society for Bone and Mineral Research 2018 Annual Meeting
  • Int'l Joint Research
• [Presentation] 骨粗鬆症治療アップデート -骨折と骨粗鬆症の接点- (2017)
  • Author(s): 酒井昭典
  • Organizer: 第90回日本整形外科学会学術集総会
• [Presentation] 骨粗鬆症薬物療法におけるT2Tの考え方 (2017)
  • Author(s): 酒井昭典
  • Organizer: 第90回日本整形外科学会学術集総会
• [Presentation] 非定型大腿骨骨折と顎骨壊死の発生における薬剤関与のエビデンス (2017)
  • Author(s): 酒井昭典、善家雄吉、目貫邦隆、山中芳亮、田島貴文、塚本学、岡田祥明
  • Organizer: 第37回日本骨形態計測学会
• [Presentation] 高齢者の橈骨遠位端骨折に対する治療とビタミンDの多面的作用 (2017)
  • Author(s): 酒井昭典
  • Organizer: 第133回西日本整形・災害外科学会学術集会
• [Presentation] aldehyde dehydrogenase 2遺伝子欠損マウスは非荷重環境下において骨形成低下により皮質骨量が減少する (2017)
  • Author(s): 田島貴文、目貫邦隆、大隈佳世子、塚本学、福田北斗、岡田祥明、酒井昭典
  • Organizer: 第37回日本骨形態計測学会
• [Presentation] 骨折の治療・予防と骨代謝制御 (2016)
  • Author(s): 酒井昭典
  • Organizer: 第31回 日本整形外科学会基礎学術集会
  • Place of Presentation: 福岡国際会議場（福岡県・福岡市）
  • Year and Date: 2016-10-14
  • Invited
• [Presentation] Disruption of aldehyde dehydrogenase 2 (Aldh2) gene results in suppression of increase in trabecular bone mass after climbing exercise in growing mice (2016)
  • Author(s): kayoko Furukawa, Kunitaka Menuki, Manabu Tsukamoto, Takafumi Tajima, Hokuto Fukuda, Toshiharu Mori, Akinori Sakai
  • Organizer: ASBMR (American Society for Bone and Mineral Research) 2016 Annual Meeting
  • Place of Presentation: Georgia World Congress Center(Atlanta・USA)
  • Year and Date: 2016-09-17
  • Int'l Joint Research
• [Presentation] 骨折と骨代謝の接点 (2016)
  • Author(s): 酒井昭典
  • Organizer: 第42回 日本骨折治療学会
  • Place of Presentation: 京王プラザホテル（東京都・新宿区）
  • Year and Date: 2016-07-01
  • Invited
• [Presentation] 骨粗鬆症に対する治療薬剤の選択 (2015)
  • Author(s): 酒井昭典
  • Organizer: 第42回日本股関節学会学術集会
  • Place of Presentation: グランフロント大阪（大阪市）
  • Year and Date: 2015-10-30
  • Invited
• [Presentation] 橈骨遠位端骨折から骨を科学する (2015)
  • Author(s): 酒井昭典、善家雄吉、目貫邦隆、平澤英幸、田島貴文、古川佳世子
  • Organizer: 第30回日本整形外科学会基礎学術集会
  • Place of Presentation: 富山国際会議場（富山市）
  • Year and Date: 2015-10-22
  • Invited
• [Presentation] 非荷重環境では骨髄細胞中のカルシトニン受容体発現が亢進することにより、エルカトニンは骨吸収抑制作用を増強し骨量減少を防止する (2015)
  • Author(s): 塚本学、目貫邦隆、村井哲平、畠山昌久、高田真一朗、古川佳世子、酒井昭典
  • Organizer: 第30回日本整形外科学会基礎学術集会
  • Place of Presentation: 富山国際会議場（富山市）
  • Year and Date: 2015-10-22
• [Presentation] Correlation of albumin/globulin ratio (A/G ratio) with forearm bone mineral density in women above 50 years of age. (2015)
  • Author(s): Furukawa K, Menuki K, Zenke Y, Yamanaka Y, Hirasawa H, Tajima T, Sakai A
  • Organizer: The American Society for Bone and Mineral Research 2015 Annual Meeting
  • Place of Presentation: Seattle, Washington, USA
  • Year and Date: 2015-10-09
  • Int'l Joint Research
• [Presentation] Elcatonin prevents bone loss due to skeletal unloading by suppressing bone resorption with unloading-induced high expression of calcitonin receptors in bone marrow cells. (2015)
  • Author(s): Tsukamoto M, Menuki K, Murai T, Hatakeyama A, Takeda S, Furukawa K, Sakai A
  • Organizer: The American Society for Bone and Mineral Research 2015 Annual Meeting
  • Place of Presentation: Seattle, Washington, USA
  • Year and Date: 2015-10-09
  • Int'l Joint Research
• [Presentation] High-fat diet can elicit diverse effects on bone in relation with different sex hormone status. (2015)
  • Author(s): Tanaka S, Tsuchiya T, Sakai A, Oda H
  • Organizer: The American Society for Bone and Mineral Research 2015 Annual Meeting
  • Place of Presentation: Seattle, Washington, USA
  • Year and Date: 2015-10-09
  • Int'l Joint Research
• [Presentation] Difference and similarity between alendronate oral jelly therapy and alendronate weekly tablet therapy in the treatment of osteoporosis in Japanese clinical ssettings. (2015)
  • Author(s): Okimoto N, Ikeda S, Matsumoto H, Sakai A
  • Organizer: The American Society for Bone and Mineral Research 2015 Annual Meeting
  • Place of Presentation: Seattle, Washington, USA
  • Year and Date: 2015-10-09
  • Int'l Joint Research
• [Presentation] 骨折と骨代謝の接点 (2015)
  • Author(s): 酒井昭典
  • Organizer: 第33回日本骨代謝学会学術集会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2015-07-23
  • Invited
• [Presentation] 非荷重環境では骨髄細胞中のカルシトニン受容体発現が亢進することにより、エルカトニンは骨吸収抑制作用を増強し骨量減少を防止する (2015)
  • Author(s): 塚本学、目貫邦隆、村井哲平、畠山昌久、高田真一朗、古川佳世子、酒井昭典
  • Organizer: 第33回日本骨代謝学会学術集会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2015-07-23
• [Book] TEXT 整形外科学 改訂5版 (2019)
  • Author(s): 酒井昭典
  • Total Pages: 486
  • Publisher: 南山堂（株）
  • ISBN: 9784525320553
• [Book] 骨粗鬆症患者に対する手術と成功の秘訣 (2019)
  • Author(s): 酒井昭典
  • Total Pages: 260
  • Publisher: （株）メジカルビュー社
  • ISBN: 9784758318747
• [Book] 高齢者上肢骨折に対する手術 (2018)
  • Author(s): 酒井昭典
  • Total Pages: 165
  • Publisher: メジカルビュー社（株)
• [Book] 今日の治療指針 2017年版［デスク判］ (2017)
  • Author(s): 酒井昭典（総編集）福井次矢、高木誠、小室一成
  • Total Pages: 1999
  • Publisher: 医学書院
  • ISBN: 9784260028080
• [Book] ファーマナビゲーター 抗RANKL抗体編 (2016)
  • Author(s): 塚本学、酒井昭典
  • Total Pages: 435
  • Publisher: メディカルレビュー社
• [Book] 骨粗鬆症診療ハンドブック 改訂第6版 (2016)
  • Author(s): 酒井昭典
  • Total Pages: 383
  • Publisher: 医薬ジャーナル社
• [Book] 臨床医とコメディカルのための最新リハビリテーション (2016)
  • Author(s): 酒井昭典
  • Total Pages: 414
  • Publisher: 寺田国際事務所/先端医療技術研究所
• [Book] 「骨」を知る53の質問 (2015)
  • Author(s): 酒井昭典
  • Total Pages: 211
  • Publisher: 医薬ジャーナル社