p130Cas is involved in osteocyte's mechanosensory function in bone homeostasis
Project/Area Number |
15K10501
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
Principal Investigator |
Miyazaki Tsuyoshi 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (50376480)
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Co-Investigator(Kenkyū-buntansha) |
時村 文秋 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (80242147)
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Co-Investigator(Renkei-kenkyūsha) |
SAWADA YASUHIRO 国立障害者リハビリテーションセンター(研究所), 研究所 運動機能系障害研究部, 部長 (50313135)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | メカニカルストレス / 骨細胞 / unloading / p130Cas |
Outline of Final Research Achievements |
Osteocytes are recognized as mechanosensory cells, although it is largely unknown how bone metabolism is mechanically modulated. Here, we report that p130Cas (Cas) plays a major role in osteocyte mechanosensing to subsequently support bone homeostasis. Osteocyte-specific Cas knockout (Cas cKO) mice exhibit osteopenia. We used a mouse bone-unloading model, in which one of the hindlimbs of each individual mouse was subjected to sciatic and femoral nerve resection. Unloaded femurs exhibited a significant reduction of bone volume as compared with their contralateral controls. Unloaded bones of Casflox/flox mice exhibited significant reduction of bone volume with significantly increased bone resorption parameters. In contrast, bone resorption parameters remained unaltered upon unloading in Cas cKO mice, although they showed a tendency of unloading-induced decrease in bone volume. These results suggest that Cas in osteocytes is involved in the mechanosensory function in bone.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Revision with locking plate and sliding inlay bone graft for hypertrophic nonunion after combined treatment of Ender nails and teriparatide for atypical femoral stress fracture: A unique case report2017
Author(s)
Akira Koshiishi, Hiroshi Hamaji, Yasuhiro Wada, Kimiteru Ito, Kei Wagatsuma, Kenji Ishii, Masakazu Kanetaka, Soichiro Kaneko, Shigehito Uezono, Naoko Shoda, Yorito Anamizu, Fumiaki Tokimura, and Tsuyoshi Miyazaki
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Journal Title
J Orthopedics Rheumatol.
Volume: 4
Pages: 01-06
Related Report
Peer Reviewed / Open Access
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[Journal Article] Does osteophytosis at the knee predict health-related quality of life decline? A 3-year follow-up of the ROAD study.2015
Author(s)
Muraki S, Akune T, Nagata K, Ishimoto Y, Yoshida M, Tokimura F, Tanaka S, Kawaguchi H, Nakamura K, Oka H, Yoshimura N.
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Journal Title
Clin Rheumatol.
Volume: 34
Issue: 9
Pages: 1589-1597
DOI
Related Report
Peer Reviewed
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