Pharmakocinetics of landiolol in patients undergoing cardiac surgery
| Project/Area Number |
15K10502
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 薬物動態 / 塩酸ランジオロール / TCIシステムによる実際の投与 / 血行動態安定 / 有害事象なし / 検体処理後凍結保存 / TCIシステムの良好な稼動 / 想定内の実測血漿濃度 |
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| Outline of Final Research Achievements |
Measured concentrations of landiolol were similar to the predicted concentrations of landiolol calculated using parameters from patients undergoing vascular surgery. Although pharmacokinetic parameters of landiolol in healthy volunteers were smaller than those in patients undergoing cardiac surgery, there was no large difference. High sensitivity to landiolol in
high-risk patients are thought to be contributed to both pharmacodynamics (PD) and pharmacokinetics (PK), but the degree may be larger for PD than PK.
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Report
(4 results)
Research Products
(10 results)
