Free radical scavenger edaravone produces robust neuroprotection in a rat model of spinal cord injury
| Project/Area Number |
15K10505
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Niigata University |
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Principal Investigator |
ISHII Hideaki 新潟大学, 医歯学総合病院, 特任准教授 (60529775)
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| Co-Investigator(Kenkyū-buntansha) |
河野 達郎 東北医科薬科大学, 医学部, 教授 (00313536)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 脊髄損傷 / エダラボン |
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| Outline of Final Research Achievements |
We used multimodal approach to evaluate the effects of edaravone in a rat model of spinal cord injury (SCI). SCI was induced by extradural compression of the spinal cord at the thoracic level. Moderate-dose (3 mg/kg/h) edaravone was administered 30 min prior to compression, at the start of compression, or 10 min after decompression. Preemptive administration regimens resulted in significantly improved spinal motor-evoked potentials (MEPs). A moderate-dose of edaravone resulted in significant attenuation of lipid peroxidation, as evidenced by lower concentrations of free radical malonyldialdehyde (MDA) in the spinal cord at 3 h post-SCI. Both moderate- and high-dose edaravone resulted in significant functional improvements evidenced by better Basso-Beattie-Bresnahan (BBB) scores and better performance on the inclined plane during 8-wk period post-SCI.
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Report
(4 results)
Research Products
(3 results)
