Perioperative management for the hyperglycemia from the viewpoint of cerebral vascular endothelial function - Strategy for prevention of cerebrovascular disorder
| Project/Area Number |
15K10509
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Gifu University |
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Principal Investigator |
Iida Hiroki 岐阜大学, 大学院医学系研究科, 教授 (30159561)
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| Co-Investigator(Kenkyū-buntansha) |
田辺 久美子 岐阜大学, 大学院医学系研究科, 准教授 (30402209)
飯田 真美 岐阜大学, 大学院医学系研究科, 非常勤講師 (80350859)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 高血糖 / 脳血管障害 / 血管内皮保護 / 周術期 / 酸化ストレス / プロポフォール / デスフルラン / Cranial Window / Cranial window 法 / Cranial window法 / 脳血管 / 参加ストレス / インスリン |
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| Outline of Final Research Achievements |
We examined the cerebrovascular endothelial function in rat acute hyperglycemic loading model. Acute hyperglycemia caused vascular endothelial dysfunction, and then the normalization of blood glucose by insulin restored such endothelial dysfunction. As pre-administration of apocynin (NADPH oxidase inhibitor) prevented such endothelial dysfunction, the mechanism of this dysfunction is due to oxidative stress induced by acute hyperglycemia. In the evaluation regarding the effect of general anesthetic on this endothelial dysfunction, propofol but not desflurane could improve endothelial dysfunction in cerebral vessels during acute hyperglycemic condition.
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Report
(4 results)
Research Products
(135 results)
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[Journal Article] AICAR reduces collagen-stimulated secretion of PDGF-AB and release of soluble CD40 ligand from human platelets: suppression of HSP27 phosphorylation via p44/p42 MAP kinase2016
Author(s)
Tsujimoto M, Tokuda H, Kuroyanagi G, Yamamoto N, Kainuma S, Matsushima-Nishiwaki R, Onuma T, Iida Y, Kojima A, Sawada S, Doi T, Enomoto Y, Tanabe K, Akamatsu S, Iida H, Ogura S, Otsuka T, Kozawa O, Iwama T
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Journal Title
Exp Ther Med
Volume: 12
Pages: 1107-1112
Related Report
Peer Reviewed / Open Access
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[Journal Article] Factor Xa inhibitor suppresses the release of phosphorylated HSP27 from collagen-stimulated human platelets: inhibition of HSP27 phosphorylation via p44/p42 MAP kinase.2016
Author(s)
Tsujimoto M, Kuroyanagi G, Matsushima-Nishiwaki R, Kito Y, Enomoto Y, Iida H, Ogura S, Otsuka T, Tokuda H, Kozawa O, Iwama T
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Journal Title
PLoS One
Volume: 11
Issue: 2
Pages: e0149077-e0149077
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Thrombin Receptor-Activating Protein (TRAP)-Activated Akt Is Involved in the Release of Phosphorylated-HSP27 (HSPB1) from Platelets in DM Patients.2016
Author(s)
Tokuda H, Kuroyanagi G, Tsujimoto M, Matsushima-Nishiwaki R, Akamatsu S, Enomoto Y, Iida H, Otsuka T, Ogura S, Iwama T, Kojima K, Kozawa O.
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Journal Title
Int J Mol Sci
Volume: 17
Issue: 5
Pages: 737-737
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Release of phosphorylated HSP27(HSPB1) from platelets is accompanied with the acceleration of aggregation in diabetic patients2015
Author(s)
Tokuda H, Kuroyanagi G, Tsujimoto M, Enomoto Y, Matsushima-Nishiwaki R, Onuma T, Kojima A, Doi T, Tanabe K, Akamatsu S, Iida H, Ogura S, Otsuka Ta, Iwama T, Tanikawa T, Ishikawa K, Kojima K, Kozawa O
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Journal Title
PLoS One
Volume: 10
Issue: 6
Pages: e0128977-e0128977
DOI
Related Report
Peer Reviewed
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[Presentation] Prevalence of persistent post operative pain after thoracotomy and total knee arthroplasty: A retrospective multicenter study in japan (Japanest study group of subacute postoperative pain).2016
Author(s)
Sugiyama Y, Amaya F, Kojima K, Matsuno F, Iseki M, Takahashi M, Kawamata M. Tanaka S, Inagaki Y, Otsuki A, Yamazaki M, Ito H, Iida H
Organizer
16th world congress on pain
Place of Presentation
Yokohama
Related Report
Int'l Joint Research
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[Presentation] A1067 / Monitor 16 - The Accumulation of Neutrophil to the Endarterectomy Site Would Induce the Inflammation, and Prolongs the Duration of Assisted Ventilation on Postoperative Management of Pulmonary Endarterectomy.2016
Author(s)
Takada M, Ohsaki T, Uematsu Y, Taruishi C, Sudani T, Suzuki A, Tanaka S, Andou M, Daimaru O, Iida H
Organizer
American Soceity of Anesthesiologists 2016 Annual Meeting.
Place of Presentation
Chicago
Related Report
Int'l Joint Research
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[Presentation] 麻酔薬が糖代謝に与える影響2015
Author(s)
岩田ちひろ, 岩倉亜里沙, 村井千里, 田辺久美子, 飯田宏樹
Organizer
日本麻酔科学会東海・北陸支部第13回学術集会
Place of Presentation
名古屋
Year and Date
2015-09-05
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[Book] 神経麻酔2016
Author(s)
鬼頭和裕, 飯田宏樹
Total Pages
7
Publisher
克誠堂出版
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