| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
The neurotoxicity of anesthetics in children is currently major concern for not only for anesthesiologists but also patients and their parents. We compared the effects of the intravenous anesthetics, midazolam, propofol, and thiopental sodium on primary cultured neurons along with the course of development.
Although many in vitro studies showed that thiopental sodium is neuroprotective, clinical attempts showed unsatisfactory results. We investigated the dynamics of the intracellular calciumin the surviving neurons after hypoxic insults with or without TPS pretreatment following the application of neurotransmitters. Though TPS was neuroprotective against HI morphologically, the response not to L-glutamate but to acetylcholine was impaired. This may partially explain the inconsistent results regarding the neuroprotective effects of TPS.
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