| Project/Area Number |
15K10516
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Research Collaborator |
NAKAGAWA Masayuki 福島県立医科大学, 医学部, 博士研究員 (80457770)
SATO Keiko 福島県立医科大学, 医学部, 主任医療技師
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 局所麻酔薬 / 副作用 / 中毒 / 痙攣 / 脂肪乳剤 / リドカイン / レボブピバカイン |
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| Outline of Final Research Achievements |
We examined the efficacy of lipid rescue from neurotoxicity due to local anesthetics intoxication. Sixty rats were randomized into 6 groups. The rats in 4 groups underwent induced convulsions by injection of lidocaine or levobupivacaine via the tail vein. Immediately following the local anesthetics injection, 20% lipid emulsion; or saline was infused. In the other two groups, 20% lipid emulsion was infused before bolus injection of local anesthetics. Convulsion durations were not different among the post-treatment groups. In the lipid emulsion pre-treated groups, 50 % lidocaine-injected rats and 90 % levobupivacaine-injected rats had no convulsions. Moreover, convulsion durations in the pre-treated groups were significantly shorter than those in the post-treatment groups (p < 0.001).
Convulsions induced by intravenous injection of lidocaine or levobupivacaine were inhibited by pre-treatment with lipid emulsion, but not by treatment after local anesthetics administration.
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