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Development of the estimate method of the anesthesia depth using the Poincare plot analysis of the electroencephalogram

Research Project

Project/Area Number 15K10518
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Anesthesiology
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Hayashi Kazuko  京都府立医科大学, 医学(系)研究科(研究院), 客員講師 (40285276)

Research Collaborator SAWA Teiji  京都府立医科大学, 麻酔科学教室, 教授
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsポアンカレ プロット / 複雑系 / 脳波 / 麻酔深度 / モニタリング / 周波数解析 / bispectral analysis / 筋電図 / poincare plot / フーリエ解析連動ポアンカレプロット / 非線形解析 / 意識 / return plot / カオス
Outline of Final Research Achievements

We conducted a study to apply the quantification of the electroencephalographic Poincare plot distribution to a depth of anesthesia estimate (Poincare index). As the results, we found that Poincare index reflected depth of anesthesia well in the different anesthetic agent of various kinds of mechanisms, and in the wide age groups. The Poincare index could become a candidate for the depth of anesthesia index.
On the other hand, the relations between a BIS level and the Poincare index had two levels characteristics and the Poincare index became estranged from the BIS values in the shallow anesthesia depth. By adjustment of electroencephalographic Poincare plot index with the certain high frequency band, the BIS values will be more precisely estimated by Poincare index.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (26 results)

All 2018 2017 2016 2015

All Journal Article (12 results) (of which Peer Reviewed: 12 results,  Acknowledgement Compliant: 2 results) Presentation (12 results) (of which Int'l Joint Research: 2 results) Book (2 results)

  • [Journal Article] Dopamine D2-receptor Antagonist Droperidol Deepens Sevoflurane Anesthesia2018

    • Author(s)
      Araki, R. Hayashi, K. Sawa, T.
    • Journal Title

      Anesthesiology

      Volume: 128 Issue: 4 Pages: 754-763

    • DOI

      10.1097/aln.0000000000002046

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electroencephalographic monitoring during sevoflurane anaesthesia in an amyotrophic lateral sclerosis patient with locked-in state.2017

    • Author(s)
      Hayashi K, Araki R, Tanaka A.
    • Journal Title

      Journal of Clinical Neuroscience

      Volume: 印刷中 Pages: 126-128

    • DOI

      10.1016/j.jocn.2017.04.042

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 麻酔導入前のアミノ酸輸液で体温低下を防止できた寒冷凝集素症患者の肺切除術の麻酔経験2017

    • Author(s)
      田中暁子, 林和子, 光田慧吾, 佐和貞治
    • Journal Title

      麻酔

      Volume: 66 Pages: 1076-1078

    • NAID

      40021342083

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 麻酔導入前のアミノ酸輸液で体温低下を防止できた寒冷凝集素症患者の肺切除術の麻酔経験2017

    • Author(s)
      田中暁子、林和子、光田慧吾、佐和貞治
    • Journal Title

      麻酔

      Volume: 印刷中

    • NAID

      40021342083

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inappropriately low bispectral index of the elderly during emergence from sevoflurane anaesthesia2016

    • Author(s)
      Hayashi K
    • Journal Title

      J Clin Anesth

      Volume: 34 Pages: 279-81

    • DOI

      10.1016/j.jclinane.2016.04.052

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect-site concentrations of remifentanil causing bradycardia in hypnotic and non-hypnotic patients2016

    • Author(s)
      Hayashi K., Tanaka A.
    • Journal Title

      J Clin Monit Comput

      Volume: 印刷中 Issue: 6 Pages: 919-24

    • DOI

      10.1007/s10877-015-9794-4

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 開腹胆嚢摘出術を予定していたがビタミンK欠乏に由来すると思われる高度な凝固抑制を呈した1症例2016

    • Author(s)
      嶋本早希、田中暁子、槌田圭一郎、林和子、佐和貞治
    • Journal Title

      麻酔

      Volume: 65 Pages: 407-410

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Unpredictable interference of new transcranial motor-evoked potential monitor against the implanted pacemaker.2016

    • Author(s)
      Hayashi, K
    • Journal Title

      Journal of Clinical Anesthesia

      Volume: 35 Pages: 230-1

    • DOI

      10.1016/j.jclinane.2016.09.002

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inappropriately low bispectral index of the elderly during emergence from sevoflurane anaesthesia2016

    • Author(s)
      Hayashi K.
    • Journal Title

      Journal of Clinical Anesthesia

      Volume: 印刷中

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Falsely reduced bispectral index during light anaesthesia in the elderly.2016

    • Author(s)
      Kazuko Hayashi, Teiji Sawa
    • Journal Title

      Eur J Anaesthesiol

      Volume: 33 Issue: 2 Pages: 150-2

    • DOI

      10.1097/eja.0000000000000276

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparative study of Poincare plot analysis using short electroencephalogram signals during anaesthesia with spectral edge frequency 95 and Bispectral Index.2015

    • Author(s)
      Hayashi K, Yamada T, Sawa T.
    • Journal Title

      Anaesthesia

      Volume: 70 Issue: 3 Pages: 310-317

    • DOI

      10.1111/anae.12885

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Poincare analysis of the electroencephalogram during sevoflurane anesthesia.2015

    • Author(s)
      Hayashi, K. Mukai, N. Sawa, T.
    • Journal Title

      Clin Neurophysiol,

      Volume: 126 Issue: 2 Pages: 404-411

    • DOI

      10.1016/j.clinph.2014.04.019

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 制吐薬のセボフルラン麻酔に及ぼす影響の脳波ポワンカレプロット解析2017

    • Author(s)
      林 和子、佐和貞治
    • Organizer
      第21回日本神経麻酔集中治療学会
    • Place of Presentation
      下関
    • Year and Date
      2017-06-30
    • Related Report
      2016 Research-status Report
  • [Presentation] A low antiemetic dosage of the dopamine D2 receptor antagonist droperidol has a synergistic effect on sevoflurane anaesthesia2017

    • Author(s)
      Hayashi K, Araki R, Sawa T
    • Organizer
      THE 10TH INTERNATIONAL SYMPOSIUM ON MEMORY AND AWARENESS IN ANAESTHESIA
    • Place of Presentation
      Helsinki, Finland
    • Year and Date
      2017-06-19
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] A low antiemetic dosage of the dopamine D2 receptor antagonist droperidol has a synergistic effect on sevoflurane anaesthesia2017

    • Author(s)
      K. Hayashi, R. Araki, A. Tanaka, T. Sawa
    • Organizer
      The 10th international Symposium on Memory and Awareness in Anesthesia(MAA10)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 制吐薬のセボフルラン麻酔に及ぼす影響の脳波ポワンカレプロット解析2017

    • Author(s)
      林 和子, 佐和 貞治
    • Organizer
      第21回日本神経麻酔集中治療学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] フーリエ解析連動ポアンカレプロット統合スコア(Fc-PIS)を用いた脳波解析麻酔深度モニタの開発2017

    • Author(s)
      佐和貞治、林和子、荒木竜平
    • Organizer
      第24回日本静脈麻酔学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 筋萎縮性側索硬化症(ALS)患者の意識変容と麻酔中の脳波2016

    • Author(s)
      林 和子、田中暁子、荒木竜平、槌田圭一郎
    • Organizer
      第34回日本麻酔・集中治療テクノロジー学会
    • Place of Presentation
      東京
    • Year and Date
      2016-11-25
    • Related Report
      2016 Research-status Report
  • [Presentation] 心臓ペースメーカ埋め込み患者のMEPモニタリング.2016

    • Author(s)
      林和子、佐和貞治
    • Organizer
      第20 回日本神経麻酔集中治療学会
    • Place of Presentation
      札幌
    • Year and Date
      2016-07-15
    • Related Report
      2016 Research-status Report
  • [Presentation] 心臓ペースメーカ埋め込み患者のMEPモニタリング.2016

    • Author(s)
      林和子、佐和貞治.
    • Organizer
      第20 回日本神経麻酔集中治療学会.
    • Place of Presentation
      札幌
    • Year and Date
      2016-07-15
    • Related Report
      2015 Research-status Report
  • [Presentation] 脳波の低周波成分を用いた麻酔深度評価の試み.2016

    • Author(s)
      林和子、山下早希、田中暁子、槌田圭一郎、佐和貞治
    • Organizer
      第63回日本麻酔科学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2016-05-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 脳波の低周波成分を用いた麻酔深度評価の試み.2016

    • Author(s)
      林和子、山下早希、田中暁子、槌田圭一郎、佐和貞治
    • Organizer
      第63回日本麻酔科学会学術集会.
    • Place of Presentation
      福岡
    • Year and Date
      2016-05-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 高齢者、認知症患者の麻酔依存性脳波変化2015

    • Author(s)
      林和子、嶋本早希、田中暁子、槌田圭一郎、佐和貞治
    • Organizer
      第62回日本麻酔科学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2015-05-28
    • Related Report
      2015 Research-status Report
  • [Presentation] 高齢者の浅麻酔脳波が深麻酔(BIS<20)とモニタリングされた一例2015

    • Author(s)
      林 和子、佐和貞治
    • Organizer
      第19回日本神経麻酔集中治療学会
    • Place of Presentation
      岐阜
    • Year and Date
      2015-04-10
    • Related Report
      2015 Research-status Report
  • [Book] 麻酔・集中治療とテクノロジー2017

    • Author(s)
      林和子, 田中暁子, 荒木竜平, 槌田圭一郎, 印藤孝介
    • Total Pages
      4
    • Publisher
      克誠堂出版株式会社
    • Related Report
      2017 Annual Research Report
  • [Book] 麻酔・集中治療とテクノロジー20172017

    • Author(s)
      林 和子,田中暁子,荒木竜平,槌田圭一郎,印藤孝介
    • Publisher
      克誠堂出版株式会社
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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