| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Sepsis in elderly patients is associated initially with severe systemic inflammation, but later followed by immuno-suppressive state, which increases the risk of secondary infection. In this study we investigated the mechanism of sepsis-induced immuno-suppression and, based on the mechanism, aimed to established therapeutic strategy to reinstate impaired immune functions. Analysis of macrophages in mice with sepsis revealed that macrophages shifted to a low bactericidal phenotype (M2 type). Presentation by macrophages to T cells of antigenic peptide derived from phagocytosed bacteria is essential for mounting adaptive immune responses. We have established a screening assay system to select compounds that can facilitate antigenic peptide loading onto macrophages.
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