• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Analysis of the NF-kB pathway in the initial immune response under inflammatory conditions

Research Project

Project/Area Number 15K10530
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Anesthesiology
Research InstitutionYamagata University

Principal Investigator

Kawamae Kaneyuki  山形大学, 医学部, 教授 (70254026)

Co-Investigator(Kenkyū-buntansha) 後藤 薫  山形大学, 医学部, 教授 (30234975)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords炎症応答 / 脂質代謝酵素 / 転写活性 / 核内移行 / リン酸化 / NF-kB / p53 / 転写調節 / アポトーシス / 急性炎症応答 / 脂質性情報伝達機構 / 結合蛋白 / NF-κB / ジアシルグリセロールキナーゼ / 細胞内情報伝達機構 / TNFα
Outline of Final Research Achievements

Transcription factor NFkB plays a central role in various signaling pathways including immune response, inflammation, cell survival and death, and cancer. In the present study, we examined how zeta isoform of diacylglycerol kinase (DGK) regulates NFkB pathway. We found that after TNF-alpha stimulation DGKzeta deficiency leads to facilitated nuclear transport of NFkB p65 subunit together with its enhanced phosphorylation, thereby upregulating NFkB transcriptional activity. These results suggest that DGKzeta negatively regulates NFkB pathway and that DGKzeta downregulation may enhance inflammatory response.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (9 results)

All 2018 2017 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results) Presentation (7 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results)

  • [Journal Article] DGKζ downregulation enhances osteoclast differentiation and bone resorption activity under inflammatory conditions.2017

    • Author(s)
      Iwazaki K, Takana T, Hozumi Y, Okada M, Tsuchiya R, Iseki K, Topham MK, Kawamae K, Takagi M, Goto K
    • Journal Title

      J Cellular physiol

      Volume: 232 Issue: 3 Pages: 617-624

    • DOI

      10.1002/jcp.25461

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Arachidonoyl-Specific Diacylglycerol Kinase epsilon and the Endoplasmic Reticulum2016

    • Author(s)
      Nakano T, Matsui H, Tanaka T, Hozumi Y, Iseki K, Kawamae K, Goto K
    • Journal Title

      Front Cell Dev Biol

      Volume: 4 Pages: 132-132

    • DOI

      10.3389/fcell.2016.00132

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] DGKzeta結合蛋白NAP1-like proteins によるp53アセチル化制御を介した細胞周期およびアポトーシス制御機構の解析2018

    • Author(s)
      田中 俊昭、後藤 薫
    • Organizer
      第123回日本解剖学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Regulation of p53 and NF-kB by DGKzeta2016

    • Author(s)
      Tanaka T, Goto K
    • Organizer
      The American Society for Cell Biology Annual Meeting
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2016-12-03
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] DGKzeta 結合蛋白NAP1L1 によるNF-kB転写遺伝子Mcl-1の発現制御2016

    • Author(s)
      田中俊昭、後藤薫
    • Organizer
      第62日本解剖学会・東北北海道地方会
    • Place of Presentation
      帯広畜産大学(帯広)
    • Year and Date
      2016-09-03
    • Related Report
      2016 Research-status Report
  • [Presentation] 生体ストレスを解剖する2016

    • Author(s)
      後藤薫
    • Organizer
      第19回日本臨床救急医学会総会
    • Place of Presentation
      ビッグパレットふくしま(郡山)
    • Year and Date
      2016-05-12
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] ゼータ型DGKによるエネルギーセンサーAMPKの制御2016

    • Author(s)
      秋元 亮、田中 俊昭、八月朔日 泰和、川前 金幸、後藤 薫
    • Organizer
      第121回 日本解剖学会総会・全国学術集会
    • Place of Presentation
      ビッグパレットふくしま(福島県郡山市)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Research-status Report
  • [Presentation] Regulation of p53 and NF-kB by diacylglycerol kinase ζ.2015

    • Author(s)
      Goto K.
    • Organizer
      Fifty-Six International Symposium on “Biological Regulation and Enzyme Activity in Normal and Neoplastic Tissues”
    • Place of Presentation
      Bologna, Italy
    • Year and Date
      2015-10-05
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] DGKζ結合蛋白NAP1-like proteins によるp53アセチル化修飾はCBPおよびHDAC4との結合を介して調節される.2015

    • Author(s)
      田中 俊昭、後藤 薫
    • Organizer
      第61日本解剖学会・東北北海道地方会
    • Place of Presentation
      盛岡市観光文化交流センター(岩手県盛岡市)
    • Year and Date
      2015-08-29
    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi