| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Six-month-old male rats were underwent laparotomy and intra-peritoneal injection of lipopolysaccharide (LPS) or LPS + olanzapine for preparing a postoperative cognitive dysfunction model. Behavior observation and a maze test were performed the next day. In the Burns maze test, the LPS + olanzapine group showed significantly better results than the LPS group, which effect was similar degree to the control group that was anesthetized but not operated.
Immunohistochemical study of hippocampal microglial activity revealed that olanzapine significantly suppressed hippocampal microglial activity. On the other hand, no difference was observed in the blood cytokine measurement between the LPS and LPS + olanzapine groups.It was speculated that olanzapine has a neuroprotective / repair effect rather than a direct suppression of cytokine production.
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