| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Geriatric surgical patients are known to be susceptible to cognitive dysfunction (POCD). Recent preclinical evidence indicate that sugary-induced neuroinflammation may contribute to the pathogenesis of POCD. In this project, we investigated the effect of preoperative cognitive intervention on the development of POCD in aged rats. In an in vivo setting, the aged, but not young, rats in the sedentary group developed cognitive impairment and related hippocampal neuroinflammation following abdominal surgery. Especially, it could be avoided by preoperative cognitive intervention. In the ex vivo experiment showed that the release of proinflammatory cytokines was higher in microglia isolated from aged hippocampi compared with young hippocampi. However, preoperative cognitive intervention could reduce this exaggerated cytokine response. Our findings suggest that preoperative cognitive intervention could prevent POCD via reversion of the age-related microglial phenotype in the hippocampus.
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