postoperative delirium and oxidative stess

Research Project

Project/Area Number	15K10546
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Anesthesiology
Research Institution	Tokai University
Principal Investigator	TAKEYAMA Kazuhide 東海大学, 医学部, 准教授 (80256148)
Co-Investigator(Kenkyū-buntansha)	吉川正信東海大学, 医学部, 准教授 (90276791)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	せん妄 / 酸化ストレス / NMDA / Dアミノ酸 / Dアミノ酸酸化酵素 / NMDA受容体 / Dセリン / 譫妄 / 活性酸素 / 術後譫妄 / TRPM1
Outline of Final Research Achievements	Decreased levels of oxidative stress, xerostomia after radiation detected in D-amino acids oxidase (DAO) deficient mice compared with wild ones. DAO deficient mice have high score of cognitive function compared with wild ones. These results indicate DAO deficient mice are useful for analysis of postoperative delirium and oxidative stress.

Report

(4 results)