postoperative delirium and oxidative stess
| Project/Area Number |
15K10546
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Tokai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
吉川 正信 東海大学, 医学部, 准教授 (90276791)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | せん妄 / 酸化ストレス / NMDA / Dアミノ酸 / Dアミノ酸酸化酵素 / NMDA受容体 / Dセリン / 譫妄 / 活性酸素 / 術後譫妄 / TRPM1 |
|---|
| Outline of Final Research Achievements |
Decreased levels of oxidative stress, xerostomia after radiation detected in D-amino acids oxidase (DAO) deficient mice compared with wild ones. DAO deficient mice have high score of cognitive function compared with wild ones. These results indicate DAO deficient mice are useful for analysis of postoperative delirium and oxidative stress.
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Report
(4 results)
Research Products
(1 results)
