Role of astrocyto in enteric nervous system and effect of anesthetic on enteric nervous system
| Project/Area Number |
15K10548
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Aichi Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
木下 浩之 愛知医科大学, 公私立大学の部局等, 客員研究員 (70291490)
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| Co-Investigator(Renkei-kenkyūsha) |
Feng Guo-Gang 愛知医科大学, 薬理学, 講師 (70351111)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 局所麻酔薬 / ヒト神経芽細胞腫 / 細胞死 / T型カルシウムチャネル / ヒト神経芽腫細胞 / パッチクランプ / 消化管筋間神経叢 / イレウス |
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| Outline of Final Research Achievements |
Local anesthetic, bupivacaine, is known to have neurotoxicity. Bupivacaine decreased viability of human neuroblastoma cell line (SH-SY5Y cell). T-type calcium channel blocker exacerbated the bupivacaine induced cell death. According to the result of realtime PCR, Cav3.1 was the only subtype of T-type calcium channel which expressed on the SH-SY5Y cell.
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Report
(4 results)
Research Products
(10 results)
