| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
(1) We compared the effects of albumin and hydroxyethyl starch (HES) solutions on the physical properties of sodium hyaluronate solution, a constituent of the ESL. A 3% albumin solution decreased partial specific volumes of hyaluronate by 3% compared to HES. A 3% HES solution, but not albumin, decreased intrinsic viscosities hyaluronate by 34%. These findings suggest that HES locally restricts hyaluronate dispersion, whereas albumin contracts hyaluronate structure.
(2) We compared total fluid infusion volume in patients receiving stroke volume variation (SVV)-guided fluid therapy with or without vasopressors during hepatectomy. Fluid infusion volume during surgery did not differ significantly among the three groups. This was attributed to modest decrease of SVV following fluid boluses for vasopressor groups compared to the control group.
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