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The role and therapeutic targeting of hippocampal BDNF in neuropathic pain

Research Project

Project/Area Number 15K10560
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Anesthesiology
Research InstitutionKochi University

Principal Investigator

Yokoyama Masataka  高知大学, 教育研究部医療学系臨床医学部門, 教授 (20158380)

Co-Investigator(Kenkyū-buntansha) 河野 崇  高知大学, 教育研究部医療学系臨床医学部門, 准教授 (40380076)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords脳由来神経栄養因子 / 神経障害性痛 / 慢性痛 / 加齢 / 高齢 / 神経障害精痛 / 海馬 / BDNF
Outline of Final Research Achievements

Especially in the elderly, chronic pain is a major public-health burden because of its high prevalence and debilitating nature. Currently, however, several types of chronic pain, e.g., neuropathic pain, are still difficult to treat. In this project, we compared the pain sensitivity and BDNF levels after painful nerve injury between adult and aged rats. Furthermore, we examined the therapeutic potential of exogenous BDNF. Our findings demonstrated that aged rats were more susceptible to the development of sensitized pain behaviors than adult animals. Especially, the brain-region-specific reduction in hippocampal BDNF was significantly correlated with the neuropathic pain behaviors. The intra-nasal administration of BDNF produced significant anti-hyperalgesic effects in aged neuropathic animals. No adverse behavioral effects were observed. These findings imply that hippocampal BDNF may represent a novel modifiable pathogenic factor and therapeutic target for chronic pain.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (17 results)

All 2018 2017 2016 2015 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Acknowledgement Compliant: 3 results) Presentation (7 results) Remarks (1 results)

  • [Journal Article] Involvement of acute neuroinflammation in postoperative delirium-like cognitive deficits in rats2018

    • Author(s)
      Kawano T, Yamanaka D, Aoyama B, Tateiwa H, Shigematsu-Locatelli M, Nishigaki A, Iwata H, Locatelli FM, Yokoyama M
    • Journal Title

      J Anesth

      Volume: 印刷中 Issue: 4 Pages: 506-517

    • DOI

      10.1007/s00540-018-2504-x

    • NAID

      40021626978

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of hippocampal brain-derived neurotrophic factor in age-related differences in neuropathic pain behavior in rats.2018

    • Author(s)
      Tateiwa H, Kawano T, Nishigaki A, Yamanaka D, Aoyama B, Shigematsu-Locatelli M, Eguchi S, Locatelli FM, Yokoyama M
    • Journal Title

      Life Sciences

      Volume: 197 Pages: 56-66

    • DOI

      10.1016/j.lfs.2018.01.030

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of epigallocatechin-3-gallate on systemic inflammation-induced cognitive dysfunction in aged rats.2017

    • Author(s)
      Yamanaka D, Kawano T, Nishigaki A, Aoyama B, Tateiwa H, Shigematsu-Locatelli M, Locatelli FM, Yokoyama M
    • Journal Title

      J Anesth

      Volume: 31 Issue: 5 Pages: 726-735

    • DOI

      10.1007/s00540-017-2392-5

    • NAID

      40021346892

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The preventive effects of dexmedetomidine on endotoxin-induced exacerbated post-incisional pain in rats2017

    • Author(s)
      Yamanaka D, Kawano T, Nishigaki A, Aoyama B, Tateiwa H, Shigematsu-Locatelli M, Locatelli FM, Yokoyama M
    • Journal Title

      J Anesth

      Volume: 31 Issue: 5 Pages: 664-671

    • DOI

      10.1007/s00540-017-2374-7

    • NAID

      40021346803

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preventive effects of dexmedetomidine on the development of cognitive dysfunction following systemic inflammation in aged rats.2017

    • Author(s)
      Yamanaka D, Kawano T, Nishigaki A, Aoyama B, Tateiwa H, Shigematsu-Locatelli M, Locatelli FM, Yokoyama M.
    • Journal Title

      J Anesth

      Volume: 31 Issue: 1 Pages: 25-35

    • DOI

      10.1007/s00540-016-2264-4

    • NAID

      40021101658

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] The role of hippocampal insulin signaling on postoperative cognitive dysfunction in an aged rat model of abdominal surgery.2016

    • Author(s)
      Kawano T, Iwata H, Aoyama B, Nishigaki A, Yamanaka D, et al.
    • Journal Title

      Life Sci

      Volume: 162 Pages: 87-94

    • DOI

      10.1016/j.lfs.2016.08.020

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Intranasal midazolam administration enhances amnesic effect in rats.2016

    • Author(s)
      Kadono T, Kawano T, Yamanaka D, Tateiwa H, Urakawa M, Locatelli FM, Yokoyama M.
    • Journal Title

      J Anesth

      Volume: 30 Issue: 3 Pages: 538-541

    • DOI

      10.1007/s00540-016-2153-x

    • NAID

      40020854924

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pregabalin can prevent, but not treat, cognitive dysfunction following abdominal surgery in aged rats.2016

    • Author(s)
      Kawano T, Eguchi S, Iwata H, Yamanaka D, et al.
    • Journal Title

      Life Sci

      Volume: 148 Pages: 211-219

    • DOI

      10.1016/j.lfs.2016.02.021

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Effects and underlying mechanisms of endotoxemia on post-incisional pain in rats.2016

    • Author(s)
      Kawano T, Eguchi S, Iwata H, Yamanaka D, et al.
    • Journal Title

      Life Sci

      Volume: 148 Pages: 145-153

    • DOI

      10.1016/j.lfs.2016.01.046

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] エンドトキシン投与高齢ラット敗血症モデルに対するResveratrolの影響2017

    • Author(s)
      立岩浩規, 山中大樹, 河野 崇, 横山正尚
    • Organizer
      第44回日本集中治療医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] エンドトキシン投与敗血症モデルにおける海馬ミクログリア機能の変化: 高齢ラットを用いた検討2017

    • Author(s)
      西垣厚, 河野 崇, 山中大樹, 青山 文, 立岩浩規, 横山正尚
    • Organizer
      第44回日本集中治療医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高齢ラット敗血症後認知機能障害モデルの確立に向けて2017

    • Author(s)
      西垣 厚, 青山 文, 山中大樹, 立岩浩規, 河野 崇, 横山正尚
    • Organizer
      第21回日本神経麻酔集中治療学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 術後認知機能障害と運動耐容能の関係―ラット開腹手術モデルでの検討―2016

    • Author(s)
      立岩浩規, 河野崇, 江口覚, 山中大樹, ロカテリファブリシオ, 横山正尚
    • Organizer
      日本麻酔科学会 第63回学術集会
    • Place of Presentation
      福岡国際会議場 (福岡県・福岡市)
    • Year and Date
      2016-05-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 高齢ラット全身炎症後認知障害モデルに対するデクスメデトミジンの有効性―投与時期の違いによる影響―2016

    • Author(s)
      山中大樹, 河野崇, 立岩浩規, 江口覚, ロカテリファブリシオ, 横山正尚
    • Organizer
      日本麻酔科学会 第63回学術集会
    • Place of Presentation
      福岡国際会議場 (福岡県・福岡市)
    • Year and Date
      2016-05-26
    • Related Report
      2016 Research-status Report
  • [Presentation] ラット神経障害性痛モデルにおける脳由来神経栄養因子経鼻投与の抗痛覚過敏効果2015

    • Author(s)
      谷川悠介, 河野 崇, 山中大樹, 岩田英樹, 北村園恵, 横山正尚
    • Organizer
      第 62 回日本麻酔科学会学術集会
    • Place of Presentation
      神戸ポートピアホテル他 (兵庫県)
    • Year and Date
      2015-05-28
    • Related Report
      2015 Research-status Report
  • [Presentation] 急性術後痛に及ぼすエンドトキシンの痛覚過敏作用 -ラット皮膚切開モデルでの検討-日本区域麻酔学会2015

    • Author(s)
      浦川 愛, 河野 崇, 岩田 英樹, 山中 大樹, 横山 正尚
    • Organizer
      日本区域麻酔学会 第二回学術集会
    • Place of Presentation
      高崎ビューホテル (群馬)
    • Year and Date
      2015-04-24
    • Related Report
      2015 Research-status Report
  • [Remarks] 高知大学医学部 麻酔科学・集中治療医学講座 主要研究テーマ

    • URL

      http://www.kochi-ms.ac.jp/~fm_ansth/department/research2.html

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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