• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Crosstalk mechanism between glial cell- nerve cells with the GABA/ glutamic acid in the sensory ganglia

Research Project

Project/Area Number 15K10565
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Anesthesiology
Research InstitutionKansai University of Welfare Sciences

Principal Investigator

Hayasaki Hana  関西福祉科学大学, 保健医療学部, 准教授 (90257866)

Co-Investigator(Kenkyū-buntansha) 神原 清人  大阪医科大学, 医学部, 非常勤講師 (40298758)
福田 敦夫  浜松医科大学, 医学部, 教授 (50254272)
相馬 義郎  国際医療福祉大学, 薬学部, 教授 (60268183)
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsグルタミン酸 / GABA / 知覚神経節 / satellite cell / 三叉神経節 / グリア細胞 / AMPA / NMDAR / 三叉神経節(TG) / サテライト細胞(SC) / サテライト細胞 / VGLUT
Outline of Final Research Achievements

In late years it is found widely that glia cells are significantly involved in neuron signal transduction.
Trigeminal ganglion was a peripheral nerve, and because there was not a synapse, there was not thought to be neural transmission control, but it was found that neural transmission control by the crosstalk with the GABA which was inhibitory nerve neurotransmitter and the glutamic acid which was excitatory neurotransmitter was present between perikaryon, glia cells (satellite cells) in the ganglion.
Trigeminal nerve is the nerve cell that the head receives the pain of the face, and, as for the possibility of the control of the pain in the peripheral site, it is thought to be in a lead of the algetic incidence and reduction.

Academic Significance and Societal Importance of the Research Achievements

グリア細胞は痛覚情報伝達効率を高め、末梢では神経修復に関与すると考えられている。しかしグリア細胞は場合によっては過剰な反応や慢性的な過敏状態を引き起こし,疼痛の発症や鎮痛剤効力低下の原因にもなりうる。これらのことからニューロングリア間制御機構の解明は疼痛治療において重要である。しかし多くの不明な点が残されており、今後の研究の進展が必要である。我々の研究は末梢の知覚神経節におけるsatellite cellと神経細胞体間における抑制性神経伝達物質であるGABAと興奮性神経伝達物質であるグルタミン酸による神経伝達制御が痛覚治療に関連する可能性を見出した。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (11 results)

All 2018 2017 2016 2015

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (5 results)

  • [Journal Article] Participation of the thoracolumbar fascia in low back pain2018

    • Author(s)
      由留木裕子, 池辺るり子, 中俣恵美, 早﨑, 目崎聖子 , 玄 安季, 渡辺正仁
    • Journal Title

      総合福祉科学研究

      Volume: 10 Issue: 10 Pages: 1-7

    • DOI

      10.24614/00002579

    • NAID

      120006591444

    • URL

      https://fuksi-kagk-u.repo.nii.ac.jp/records/2704

    • Year and Date
      2018-11-30
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] カンナビジオールの治療効果とその作用機序2018

    • Author(s)
      渡辺正仁,早﨑 華,由留木裕子,渡辺克哉
    • Journal Title

      保健医療学雑誌

      Volume: 9 Pages: 117-122

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Measurement of plasma amyloid-β precursor protein APP770 concentration in healthy young volunteers: Preliminary study of APP770 as a potential biomarker for Alzheimer’s disease diagnosis.2018

    • Author(s)
      M. Watanabe, M. Yamamoto, H. Hayasaki, E. Nakamata, K. Nagino, K. Okamoto, Y. Yuri, Y. Fujii, Y. Yurugi, K. Shigemori and K. Watanabe
    • Journal Title

      J. Allied Health Sci.

      Volume: 9 Pages: 6-11

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 痛みのメカニズムと鎮痛2017

    • Author(s)
      渡辺正仁,早﨑 華,由留木裕子
    • Journal Title

      保健医療学雑誌

      Volume: 8 Pages: 50-63

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 骨格筋収縮に関与する弾性タンパク質コネクチン/タイチン2017

    • Author(s)
      渡辺正仁,早﨑 華,由留木裕
    • Journal Title

      保健医療学雑誌

      Volume: 8 Pages: 117-122

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characteristic Formation of Hyaluronan-Cartilage Link Protein-Proteoglycan Complex in Salivary Gland Tumors.2015

    • Author(s)
      Kuwabara H1, Nishikado A, Hayasaki H, Isogai Z, Yoneda M, Kawata R, Hirose Y.
    • Journal Title

      Appl Immunohistochem Mol Morphol.

      Volume: 24 Issue: 5 Pages: 373-378

    • DOI

      10.1097/pai.0000000000000198

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] APP770の正常およびアルツハイマー脳での発現2018

    • Author(s)
      早崎華 由留木裕子 桑原宏子 渡辺正仁
    • Organizer
      第37回日本認知症学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] カンナビジオールの 医療効果とその作用機序2018

    • Author(s)
      由留木裕子,渡辺正仁,早﨑 華
    • Organizer
      総合福祉科学学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Expression of APP770 in normal and Alzheimer's disease brains2017

    • Author(s)
      早崎華,由留木裕子,桑原宏子,渡辺正仁
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Research-status Report
  • [Presentation] An immunocytochemical study for the local glutamatergic system in rat trigeminal ganglion.2016

    • Author(s)
      H. Hayasaki, A. Fukuda, Y. Sohma
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2016 Research-status Report
  • [Presentation] Quantification of sAPP770 in human plasma-A trial to early detection of the Alzheimer type dementia-2015

    • Author(s)
      Hayasaki Hana, Yamamoto Maki Watanabe Masahito
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi