Involvement of fatty acid-GPR40/FFAR1 signaling in the development of neuropathic pain
Project/Area Number |
15K10566
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Anesthesiology
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Research Institution | Kobe Gakuin University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
徳山 尚吾 神戸学院大学, 薬学部, 教授 (70225358)
糟谷 史代 神戸学院大学, 薬学部, 講師 (80131522)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | 疼痛 / 脂肪酸受容体GPR40/FFAR1 / 脂肪酸 / 遊離脂肪酸 / GPR40/FFAR1 / DHA / FABP7 / iPLA2 / 脂肪酸受容体 / GPR40 / 神経障害性疼痛 |
Outline of Final Research Achievements |
In this study, we provided that brain free fatty acids-GPR40/FFAR1 signaling is an important factor in the regulation of endogenous pain control system. We found that a GPR40/FFAR1 antagonist or its deficient mice induced exacerbation of postoperative pain after paw incision. Furthermore, some free fatty acids including docosahexaenoic acid increased in the brain of an earlier phase of postoperative pain state. Finally, our findings suggested that, in the pain state, GPR40/FFAR1 signaling may play a key role in the modulation of the endogenous pain control system and that GPR40/FFAR1 signaling could be an important factor facilitating recovery of pain. Finally, modulation of these signaling may be involved in the transition from acute to chronic pain.
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Report
(4 results)
Research Products
(53 results)
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[Journal Article] Dysfunctional GPR40/FFAR1 signaling exacerbates pain behavior in mice.2017
Author(s)
Nakamoto K, Aizawa F, Miyagi K, Yamashita T, Mankura M, Koyama Y, Kasuya F, Hirasawa A, Kurihara T, Miyata A, Tokuyama S.
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Journal Title
PLoS One
Volume: 12(7)
Issue: 7
Pages: e0180610-e0180610
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] GPR40/FFAR1欠損マウスはコカイン誘発移所運動活性亢進効果が減弱している2017
Author(s)
貞村祐子, 栗原崇, 水沼亮太, 神戸悠輝, 平澤明, 中本賀寿夫, 大吉達樹, 徳山尚吾, 有田和徳, 宮田篤郎,
Organizer
第70回日本薬理学会西南部会
Related Report
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[Presentation] The dysfunction of brain free fatty acid receptor GPR40/FFAR1 signaling relate to the development of chronic pain2016
Author(s)
Kazuo Nakamoto, Takashi Nishinaka, Fuka Aizawa, Takuya Yamashita, Akira Hirasawa, Takashi Kurihara, Mitsumasa Mankura, Atsuro Miyata, Yutaka Koyama, Fumiyo Kasuya, Shogo Tokuyama
Organizer
30th CINP WORLD Congress of Neuropsychopharmacology
Place of Presentation
ソウル
Year and Date
2016-07-03
Related Report
Int'l Joint Research
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[Presentation] 長鎖脂肪酸受容体 GPR40/FFAR1の欠損は痛みを増強する2016
Author(s)
中本賀寿夫, 京谷奈月, 相澤風花, 西中崇,山下琢矢, 万倉三正, 小山豊, 糟谷史代, 平澤明, 栗原崇, 宮田篤郎, 徳山尚吾
Organizer
第 46 回 日本神経精神薬理学会
Place of Presentation
ソウル
Year and Date
2016-07-02
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