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Central effects of angiotensin receptor agonists in rat neuropathic pain models

Research Project

Project/Area Number 15K10568
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Anesthesiology
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

HARA Koji  産業医科大学, 大学病院, 准教授 (20331001)

Co-Investigator(Kenkyū-buntansha) 原西 保典  産業医科大学, 医学部, 非常勤医師 (90449942)
佐多 竹良  産業医科大学, 名誉教授、学長等, 名誉教授 (60128030)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords神経障害性痛 / アンギオテンシン受容体 / 中枢作用 / 鎮痛作用 / 抗不安作用 / 抗うつ作用 / 神経障害性疼痛
Outline of Final Research Achievements

Central effects of angiotensin receptor subtypes on hyperalgesia, anxiety, and depression were examined in rat neuropathic pain models. In chronic constriction injury (CCI) model and diabetic polyneuropathy model, AT1/AT2 receptor agonist angiotensin II and a selective AT2 receptor agonist CGA42112A inhibited cold and mechanical hyperalgesia. In contrast, an AT1 receptor antagonist losartan exacerbated cold and mechanical hyperalgesia. In the CCI model, angiotensin II and CGA42112A decreased percent of the time spent in the central area and total moving distance in the open field test. They decreased time spent in the open arms in the elevated plus maze. They also decreased swimming time and increased immobility time in the forced swim test. These results indicate that AT1 and AT2 receptors in the brain modulate nociceptive transmission and are involved in anxiety and depression in the neuropathic pain models.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (3 results)

All 2017 2016 2015

All Presentation (3 results)

  • [Presentation] ラット神経障害性疼痛モデルにおけるAMPA型グルタミン酸受容体阻害薬ペランパネルの抗痛覚過敏作用2017

    • Author(s)
      原 幸治、原西 保典、寺田 忠徳
    • Organizer
      日本麻酔科学会第64回学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ラット神経障害性疼痛モデルにおけるカンナビノイド再取り込み阻害薬AM404の抗痛覚過敏作用2016

    • Author(s)
      原 幸治、原西 保典、寺田 忠徳
    • Organizer
      日本麻酔科学会第63回学術集会
    • Place of Presentation
      福岡国際会議場(福岡県・福岡市)
    • Year and Date
      2016-05-27
    • Related Report
      2016 Research-status Report 2015 Research-status Report
  • [Presentation] ラット疼痛モデルでのグリシントランスポーター2阻害薬ALX1393の脳室内投与による鎮痛作用2015

    • Author(s)
      原 幸治、原西 保典、寺田 忠徳、高橋 良宏、小原 剛、佐多 竹良
    • Organizer
      日本麻酔科学会第62回学術集会
    • Place of Presentation
      神戸国際展示場(兵庫県・神戸市)
    • Year and Date
      2015-05-29
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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