Predictive impact of various molecular forms of PSA-related indices on developing prostate cancer and tumor aggressiveness
| Project/Area Number |
15K10575
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Gunma University |
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Principal Investigator |
Ito Kazuto 群馬大学, 大学院医学系研究科, 准教授 (00302472)
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| Research Collaborator |
SUZUKI Rie 群馬大学, 医学部附属病院 泌尿器科, 助手
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 前立腺癌 / 前立腺特異抗原 / 遊離型PSA / proPSA / PSA |
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| Outline of Final Research Achievements |
The baseline free to total prostate-specific antigen ratio was a significant
predictor of prostate cancer development. The odds ratio was 6.08 in the lowest quintile baseline free to total prostate-specific antigen ratio subgroup. No serum indices at diagnosis were associated with tumor aggressiveness. The Prostate Health Index velocity and [-2]proenzyme prostate-specific antigen/free prostate-specific antigen velocity significantly increased in patients with higher risk D’Amico risk groups and higher Gleason scores.
Those indices could be useful for a more effective individualized screening system. Longitudinal changes in [-2] proenzyme prostate-specific antigen-related indices seem to correlate with tumor aggressiveness, and they could be used as prognostic tool before treatment and during active surveillance.
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Report
(4 results)
Research Products
(7 results)
