| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
We discovered that the C7orf24 protein is highly expressed in bladder cancers. Later, Oakley et al. reported that C7orf24 exhibits functions that are related to those of γ-glutamylcyclotransferase (GGCT). GGCT is one of the major enzymes that is considered having a critical role in glutathione metabolism and it was demonstrated that GGCT is expressed in a variety of cancer cell lines and human cancer tissues. However, whether the enzymatic activity of GGCT plays a role in cancer cell proliferation or tumor progression remained unclear. In this study, we clarified the mechanism of anti-proliferation in GGCT-knockdown cells and anti-cancer activity by a peptide type GGCT inhibitor named pro-GA.
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