Development of peptide type anti cancer drugs against a novel cell growth factor identified by ourselves
| Project/Area Number |
15K10585
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
花田 英紀 滋賀医科大学, 医学部, 助教 (40555067)
影山 進 滋賀医科大学, 医学部, 講師 (50378452)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | C7orf24 / γ-グルタミルシクロトランスフェラーゼ / 抗がん剤 / ペプチド型阻害剤 / GGCT / γ－グルタミルシクロトランスフェラーゼ |
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| Outline of Final Research Achievements |
We discovered that the C7orf24 protein is highly expressed in bladder cancers. Later, Oakley et al. reported that C7orf24 exhibits functions that are related to those of γ-glutamylcyclotransferase (GGCT). GGCT is one of the major enzymes that is considered having a critical role in glutathione metabolism and it was demonstrated that GGCT is expressed in a variety of cancer cell lines and human cancer tissues. However, whether the enzymatic activity of GGCT plays a role in cancer cell proliferation or tumor progression remained unclear. In this study, we clarified the mechanism of anti-proliferation in GGCT-knockdown cells and anti-cancer activity by a peptide type GGCT inhibitor named pro-GA.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] A Novel Prodrug of a γ-Glutamylcyclotransferase Inhibitor Suppresses Cancer Cell Proliferation in vitro and Inhibits Tumor Growth in a Xenograft Mouse Model of Prostate Cancer.2018
Author(s)
Ii H, Yoshiya T, Nakata S, Taniguchi K, Hidaka K, Tsuda S, Mochizuki M, Nishiuchi Y, Tsuda Y, Ito K, Kageyama S, Yoshiki T.
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Journal Title
ChemMedChem.
Volume: 13
Issue: 2
Pages: 155-163
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] LC/QTOF-MSによるフィルグラスチムバイオ後続品の定性・成分分析2016
Author(s)
松村健吾, 大谷祐基, 大村友博, 米澤 淳, 津田真弘, 池見泰明, 中川俊作, 今井哲司, 中川貴之, 矢野育子, 吉貴達寛, 松原和夫
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Journal Title
医療薬学
Volume: 42
Pages: 613-619
NAID
Related Report
Peer Reviewed
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