| Project/Area Number |
15K10607
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
岩村 正嗣 北里大学, 医学部, 教授 (20176564)
佐藤 雄一 北里大学, 医療衛生学部, 教授 (30178793)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 膀胱癌 / 尿路上皮癌 / 蛋白質 / 抗体 / 腫瘍マーカー / 血清蛋白質 / 診断スクリーニング / 網羅的解析 |
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| Outline of Final Research Achievements |
We investigated an association of clinicopathological factors with newly detected proteins which we found using proteomics analyses in patients with bladder cancer. For example, serum PPP1CA was higher in patients with bladder cancer than in healthy controls. In addition, high levels of serum PPP1CA was associated with muscle-invasive cancer, high grade, the status of lymphovascular invasion and poor prognosis. Using cisplatin resisted bladder cancer cell line, we identified 25 obviously different spots for naive bladder cancer cell line. Seven spots had increased expression and 18 spots had decreased expression in cisplatin-resisted cell compared to those in naive cell. We will plan to examine whether the rest of bladder specific and cisplatin-resisted proteins detected in this project would be matched in real world clinical scenario.
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