Analysis of newly detected serum protein and trial of establishment of diagnostic tool in patients with bladder cancer
| Project/Area Number |
15K10607
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
岩村 正嗣 北里大学, 医学部, 教授 (20176564)
佐藤 雄一 北里大学, 医療衛生学部, 教授 (30178793)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 膀胱癌 / 尿路上皮癌 / 蛋白質 / 抗体 / 腫瘍マーカー / 血清蛋白質 / 診断スクリーニング / 網羅的解析 |
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| Outline of Final Research Achievements |
We investigated an association of clinicopathological factors with newly detected proteins which we found using proteomics analyses in patients with bladder cancer. For example, serum PPP1CA was higher in patients with bladder cancer than in healthy controls. In addition, high levels of serum PPP1CA was associated with muscle-invasive cancer, high grade, the status of lymphovascular invasion and poor prognosis. Using cisplatin resisted bladder cancer cell line, we identified 25 obviously different spots for naive bladder cancer cell line. Seven spots had increased expression and 18 spots had decreased expression in cisplatin-resisted cell compared to those in naive cell. We will plan to examine whether the rest of bladder specific and cisplatin-resisted proteins detected in this project would be matched in real world clinical scenario.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Single-agent Taxane Versus Taxane-containing Combination Chemotherapy as Salvage Therapy for Advanced Urothelial Carcinoma2016
Author(s)
Guru Sonpavde , Gregory R. Pond, Toni K. Choueiri, Stephanie Mullane, Guenter Niegisch, Peter Albers, Andrea Necchi, Giuseppe Di Lorenzo, Carlo Buonerba, Antonio Rozzi, Kazumasa Matsumoto, Jae-Lyun Lee, Hiroshi Kitamura, Haruki Kume, Joaquim Bellmunt
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Journal Title
EUROPEAN UROLOGY
Volume: 69
Pages: 255-260
Related Report
Int'l Joint Research
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[Journal Article] Second-Line Chemotherapy for Metastatic Urothelial Carcinoma: Importance of Lymph Node-Only Metastasis as a Prognostic Factor and Construction of a Prognostic Model2016
Author(s)
Samer Salah, Jae-Lyun Lee, Antonio Rozzi, Hiroshi Kitamura, Kazumasa Matsumoto, Sandy Srinivas, Rafael Morales-Barrera, Joan Carles, Rami Al-Wardat, Kamal Al-Rabi, Mohammad Maakoseh
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Journal Title
Clinical Genitourinary Cancer
Volume: 14
Issue: 3
Pages: 255-260
DOI
Related Report
Int'l Joint Research
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[Presentation] Transition to robot-assisted laparoscopic prostatectomy is associated with a reduction of positive surgical margin2015
Author(s)
K Tabata,T Satoh,K Matsumoto,H Tsumura,T Hirayama,M Nishi,T Fujita,D Ishii,K Yoshida,M Iwamura
Organizer
33rd World Congress of Endourology & SWL
Place of Presentation
London,UK Excel London
Year and Date
2015-10-03
Related Report
Int'l Joint Research
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[Presentation] 進行性膀胱癌の治療2015
Author(s)
松本和将
Organizer
北九州市泌尿器科医会 平成27年度 第3回研修会
Place of Presentation
ステーションホテル小倉(福岡県北九州市)
Year and Date
2015-07-30
Related Report
Invited
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[Book] Chemoradiotherapy2017
Author(s)
Kazumasa Matsumoto,Masaomi Ikeda, Takahiro Hirayama,Daisuke Ishii,Masatsugu Iwamura
Total Pages
69
Publisher
Nova Science Publishers,Inc
ISBN
9781536107227
Related Report
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[Book] Chemoradiotherapy2017
Author(s)
Kazumasa Matsumoto, Masaomi Ikeda, Takahiro Hirayama, Daisuke Ishii, Masatsugu Iwamura
Total Pages
81
Publisher
Nova Science Publishers,Inc
Related Report
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