| Project/Area Number |
15K10609
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Tokai University (2017)
Keio University (2015-2016) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
菊地 栄次 慶應義塾大学, 医学部(信濃町), 准教授 (10286552)
小坂 威雄 慶應義塾大学, 医学部, 講師 (30445407)
松本 一宏 慶應義塾大学, 医学部(信濃町), 助教 (80366153)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 尿路上皮癌 / 耐性機序 / 血管新生 / ケモカイン / 膀胱癌 / 前立腺癌 / バイオマーカー / MUC1 / 喫煙 / 好中球 / 単球 / 上皮間葉転換 / MCP-1 / 予後 |
|---|
| Outline of Final Research Achievements |
Immunohistochemical staining of MCP-1, expression of angiogenesis and angiotensin receptor (AT1R) in clinical specimens of urothelial carcinoma was performed, and correlation with its prognosis was confirmed. In addition, it was revealed that the expression of FBX032, a ubiquitin ligase, is deeply involved in induction of EMT in the study using cisplatin resistant bladder cancer cells.
Clinically it was shown that the hemocyte dynamics before treatment is useful as a prognostic predictor in patients with urothelial carcinoma patients with history of smoking as well as for patients with castration resistant prostate cancer.
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