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Role of chemokine in urothelial cancer progression

Research Project

Project/Area Number 15K10609
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionTokai University (2017)
Keio University (2015-2016)

Principal Investigator

MIYAJIMA Akira  東海大学, 医学部, 教授 (90245572)

Co-Investigator(Kenkyū-buntansha) 菊地 栄次  慶應義塾大学, 医学部(信濃町), 准教授 (10286552)
小坂 威雄  慶應義塾大学, 医学部, 講師 (30445407)
松本 一宏  慶應義塾大学, 医学部(信濃町), 助教 (80366153)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords尿路上皮癌 / 耐性機序 / 血管新生 / ケモカイン / 膀胱癌 / 前立腺癌 / バイオマーカー / MUC1 / 喫煙 / 好中球 / 単球 / 上皮間葉転換 / MCP-1 / 予後
Outline of Final Research Achievements

Immunohistochemical staining of MCP-1, expression of angiogenesis and angiotensin receptor (AT1R) in clinical specimens of urothelial carcinoma was performed, and correlation with its prognosis was confirmed. In addition, it was revealed that the expression of FBX032, a ubiquitin ligase, is deeply involved in induction of EMT in the study using cisplatin resistant bladder cancer cells.
Clinically it was shown that the hemocyte dynamics before treatment is useful as a prognostic predictor in patients with urothelial carcinoma patients with history of smoking as well as for patients with castration resistant prostate cancer.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (11 results)

All 2018 2017 2016 2015

All Journal Article (10 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 10 results,  Open Access: 6 results,  Acknowledgement Compliant: 2 results) Presentation (1 results) (of which Invited: 1 results)

  • [Journal Article] Vasohibin-1 as a novel microenvironmental biomarker for patient risk reclassification in low-risk prostate cancer2018

    • Author(s)
      Kobayashi Hiroaki, Kosaka Takeo, Mikami Shuji, Miyazaki Yasumasa, Matsumoto Kazuhiro, Kikuchi Eiji, Miyajima Akira, Kameyama Kaori, Sato Yasufumi, Oya Mototsugu
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 12 Pages: 10203-10210

    • DOI

      10.18632/oncotarget.23011

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Verification of the International Society of Urological Pathology recommendations in Japanese patients with clear cell renal cell carcinoma.2018

    • Author(s)
      Kim H, Inomoto C, Uchida T, Furuya H, Komiyama T, Kajiwara H, Kobayashi H, Nakamura N, Miyajima A
    • Journal Title

      Int J Oncol

      Volume: 52 Pages: 1139-1148

    • DOI

      10.3892/ijo.2018.4294

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reactive oxygen species induction by cabazitaxel through inhibiting Sestrin-3 in castration resistant prostate cancer.2017

    • Author(s)
      prostate cancer. Kosaka T, Hongo H, Miyazaki Y, Nishimoto K, Miyajima A, Oya M.
    • Journal Title

      Oncotarget.

      Volume: 8(50) Issue: 50 Pages: 87675-87683

    • DOI

      10.18632/oncotarget.21147

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic significance of erythrocyte protein band 4.1-like5 expression in upper urinary tract urothelial carcinoma2017

    • Author(s)
      Daimon T, Kosaka T, Kikuchi E, Mikami S, Miyazaki Y, Hashimoto A, Hashimoto S, Mizuno R, Miyajima A, Okada Y, Sabe H, and Oya M
    • Journal Title

      Urol Oncol

      Volume: 35(9) Issue: 9 Pages: 543.e17-543.e24

    • DOI

      10.1016/j.urolonc.2017.04.008

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Preoperative Neutrophil-to-lymphocyte Ratio is a Novel Biomarker for Predicting Worse Clinical Outcomes in Non-muscle Invasive Bladder Cancer Patients with a Previous History of Smoking.2016

    • Author(s)
      Ogihara K, Kikuchi E, Yuge K, Yanai Y, Matsumoto K, Miyajima A, Asakura H, Oya M.
    • Journal Title

      Annals of surgical oncology

      Volume: 23 Issue: S5 Pages: 1039-1047

    • DOI

      10.1245/s10434-016-5578-4

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Urinary pH Levels are Strongly Associated with Bladder Recurrence After Nephroureterectomy in Upper Tract Urothelial Carcinoma Patients with a Smoking History.2016

    • Author(s)
      Ide H, Kikuchi E, Hagiwara M, Hayakawa N, Hongo H, Miyajima A, Oya M.
    • Journal Title

      Annals of surgical oncology

      Volume: 23 Issue: S5 Pages: 1029-1038

    • DOI

      10.1245/s10434-016-5555-y

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] High Absolute Monocyte Count Predicts Poor Clinical Outcome in Patients with Castration-Resistant Prostate Cancer Treated with Docetaxel Chemotherapy.2016

    • Author(s)
      Shigeta K, Kosaka T, Kitano S, Yasumizu Y, Miyazaki Y, Mizuno R, Shinojima T, Kikuchi E, Miyajima A, Tanoguchi H, Hasegawa S, Oya M.
    • Journal Title

      Annals of Surgical Oncology

      Volume: 23(12) Issue: 12 Pages: 4115-4122

    • DOI

      10.1245/s10434-016-5354-5

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Acquired platinum resistance involves epithelial to mesenchymal transition through ubiquitin ligase FBXO32 dysregulation.2016

    • Author(s)
      Tanaka N, Kosaka T, Miyazaki Y, Mikami S, Niwa N, Otsuka Y, Minamishima YA, Mizuno R, Kikuchi E, Miyajima A, Sabe H, Okada Y, Uhl P, Suematsu M, Oya M.
    • Journal Title

      JCI Insight

      Volume: 1

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Renin-angiotensin system blockade: Its contribution and controversy.2015

    • Author(s)
      Miyajima A, Kosaka T, Kikuchi E, Oya M.
    • Journal Title

      Int J Urol

      Volume: 22 Issue: 8 Pages: 721-730

    • DOI

      10.1111/iju.12827

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Prognostic Impact of Renin-Angiotensin System Blockade on Renal Cell Carcinoma After Surgery.2015

    • Author(s)
      Miyajima A, Yazawa S, Kosaka T, Tanaka N, Shirotake S, Mizuno R, Kikuchi E, Oya M.
    • Journal Title

      Ann Surg Oncol

      Volume: 22 Issue: 11 Pages: 3751-3759

    • DOI

      10.1245/s10434-015-4436-0

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 加齢に伴う腎泌尿器疾患に置けるRAS阻害2015

    • Author(s)
      宮嶋 哲
    • Organizer
      第9回眼抗加齢医学研究会講習会
    • Place of Presentation
      時事通信ホール(東京都中央区)
    • Year and Date
      2015-09-19
    • Related Report
      2015 Research-status Report
    • Invited

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Published: 2015-04-16   Modified: 2019-12-27  

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