Role of chemokine in urothelial cancer progression
Project/Area Number |
15K10609
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Urology
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Research Institution | Tokai University (2017) Keio University (2015-2016) |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
菊地 栄次 慶應義塾大学, 医学部(信濃町), 准教授 (10286552)
小坂 威雄 慶應義塾大学, 医学部, 講師 (30445407)
松本 一宏 慶應義塾大学, 医学部(信濃町), 助教 (80366153)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
Keywords | 尿路上皮癌 / 耐性機序 / 血管新生 / ケモカイン / 膀胱癌 / 前立腺癌 / バイオマーカー / MUC1 / 喫煙 / 好中球 / 単球 / 上皮間葉転換 / MCP-1 / 予後 |
Outline of Final Research Achievements |
Immunohistochemical staining of MCP-1, expression of angiogenesis and angiotensin receptor (AT1R) in clinical specimens of urothelial carcinoma was performed, and correlation with its prognosis was confirmed. In addition, it was revealed that the expression of FBX032, a ubiquitin ligase, is deeply involved in induction of EMT in the study using cisplatin resistant bladder cancer cells. Clinically it was shown that the hemocyte dynamics before treatment is useful as a prognostic predictor in patients with urothelial carcinoma patients with history of smoking as well as for patients with castration resistant prostate cancer.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Prognostic significance of erythrocyte protein band 4.1-like5 expression in upper urinary tract urothelial carcinoma2017
Author(s)
Daimon T, Kosaka T, Kikuchi E, Mikami S, Miyazaki Y, Hashimoto A, Hashimoto S, Mizuno R, Miyajima A, Okada Y, Sabe H, and Oya M
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Journal Title
Urol Oncol
Volume: 35(9)
Issue: 9
Pages: 543.e17-543.e24
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] High Absolute Monocyte Count Predicts Poor Clinical Outcome in Patients with Castration-Resistant Prostate Cancer Treated with Docetaxel Chemotherapy.2016
Author(s)
Shigeta K, Kosaka T, Kitano S, Yasumizu Y, Miyazaki Y, Mizuno R, Shinojima T, Kikuchi E, Miyajima A, Tanoguchi H, Hasegawa S, Oya M.
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Journal Title
Annals of Surgical Oncology
Volume: 23(12)
Issue: 12
Pages: 4115-4122
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Acquired platinum resistance involves epithelial to mesenchymal transition through ubiquitin ligase FBXO32 dysregulation.2016
Author(s)
Tanaka N, Kosaka T, Miyazaki Y, Mikami S, Niwa N, Otsuka Y, Minamishima YA, Mizuno R, Kikuchi E, Miyajima A, Sabe H, Okada Y, Uhl P, Suematsu M, Oya M.
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Journal Title
Related Report
Peer Reviewed
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