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Novel strategy for castration-resistant prostate cancer using adipose-derived stromal cell

Research Project

Project/Area Number 15K10611
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionFujita Health University (2017-2019)
Osaka Medical College (2015-2016)

Principal Investigator

Kiyoshi Takahara  藤田医科大学, 医学部, 准教授 (90418939)

Project Period (FY) 2015-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords前立腺癌 / 脂肪幹細胞 / 腫瘍学
Outline of Final Research Achievements

Mesenchymal stem cells (MSCs) have generated a great deal of interest in the field of regenerative medicine. Adipose-derived stromal cell (AdSC) are known to exhibit extensive proliferation potential and can undergo multilineage differentiation, sharing similar characteristics to bone marrow-derived MSC. We assessed the degree to which AdSC affect the proliferation of prostate cancer (PCa) cell (LNCaP, PC3, and PC3M-luc2) (control: NHDF). Both in vitro and in vivo experiments exhibited the inhibitory effect of AdSC on PCa cell proliferation inducing apoptosis and PCa growth. Since autologous AdSC can be easily isolated from adipose tissue without any ethical concerns, we suggest that therapy with these cells could be a novel approach for patients with PCa.

Academic Significance and Societal Importance of the Research Achievements

体性間葉系幹細胞(脂肪幹細胞)を用いた自家細胞移植による組織治療は、胚性幹(ES)細胞移植や他家臓器移植治療とは異なり、倫理面や拒絶反応などの問題が回避でき、また、簡便に行える治療法として、広く普及させることができる点が意義深く、前立腺癌の新規治療法の一つとなり得る可能性が示唆されれた。

Report

(6 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (29 results)

All 2018 2017 2016 2015

All Journal Article (10 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 10 results,  Open Access: 6 results,  Acknowledgement Compliant: 1 results) Presentation (19 results) (of which Int'l Joint Research: 7 results)

  • [Journal Article] A Panel of MicroRNA Signature as a Tool for Predicting Survival of Patients with Urothelial Carcinoma of the Bladder2018

    • Author(s)
      Inamoto Teruo、Uehara Hirofumi、Akao Yukihiro、Ibuki Naokazu、Komura Kazumasa、Takahara Kiyoshi、Takai Tomoaki、Uchimoto Taizo、Saito Kenkichi、Tanda Naoki、Yoshikawa Yuki、Minami Koichiro、Hirano Hajime、Nomi Hayahito、Kato Ryuji、Hayashi Tetsuya、Azuma Haruhito
    • Journal Title

      Disease Markers

      Volume: 2018 Pages: 1-6

    • DOI

      10.1155/2018/5468672

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Novel Combination RNAi toward Warburg Effect by Replacement with miR-145 and Silencing of PTBP1 Induces Apoptotic Cell Death in Bladder Cancer Cells.2017

    • Author(s)
      Takai T, Yoshikawa Y, Inamoto T, Minami K, Taniguchi K, Sugito N, Kuranaga Y, Shinohara H, Kumazaki M, Tsujino T, Takahara K, Ito Y, Akao Y, Azuma H.
    • Journal Title

      Int J Mol Sci.

      Volume: 18 Issue: 1 Pages: 179-179

    • DOI

      10.3390/ijms18010179

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mycophenolate mofetil(MMF)の後発薬変更により著しく血中濃度が低下した2症例2016

    • Author(s)
      平野 一、松永知久、前之園 良一、能見勇人、吉川勇希、辻野拓也、内本泰三、齋藤賢吉、髙井朋聡、反田 直希、枝川 右、高原 健、稲元輝生、木山 賢、松村英樹、中倉兵庫、芦田 明、東 治人.
    • Journal Title

      移植

      Volume: 51 Pages: 228-30

    • NAID

      130005260513

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 当院におけるミコフェノール酸モフェチル(MMF)後発薬の使用経験2016

    • Author(s)
      平野 一、松永知久、前之園良一、能見勇人、辻野拓也、吉川勇希、反田 直希、内本泰三、上原博史、高原 健、稲元輝生、東 治人.
    • Journal Title

      日本臨床腎移植学会雑誌

      Volume: 4 Pages: 251-2

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] microRNA-145 Mediates the Inhibitory Effect of Adipose Tissue-Derived Stromal Cells on Prostate Cancer.2016

    • Author(s)
      Takahara K,Ii M, Inamoto T, Nakagawa T, Ibuki N, Yoshikawa Y, Tsujino T, Uchimoto T, Saito K, Takai T, Tanda N, Minami K, Uehara H, Komura K, Hirano H, Nomi H, Kiyama S, Asahi M, Azuma H.
    • Journal Title

      Stem Cells Dev

      Volume: 25 Issue: 17 Pages: 1290-8

    • DOI

      10.1089/scd.2016.0093

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Feasibility of Photodynamic Diagnosis for Challenging TURBt Cases Including Muscle Invasive Bladder Cancer, BCG Failure or 2nd-TUR2015

    • Author(s)
      Takai T, Inamoto T, Komura K, Yoshikawa Y, Uchimoto T, Saito K, Tanda N, Kouno J, Minami K, Uehara H, Takahara K, Hirano H, Nomi H, Kiyama S, Azuma H.
    • Journal Title

      Asian Pac J Cancer Prev.

      Volume: 16 Pages: 2297-2301

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intravesical administration of exogenous microRNA-145 as a therapy for mouse orthotopic human bladder cancer xenograft.2015

    • Author(s)
      Inamoto T, Taniguchi K, Takahara K, Iwatsuki A, Takai T, Komura K, Yoshikawa Y, Uchimoto T, Saito K, Tanda N, Kouno J, Minami K, Uehara H, Hirano H, Nomi H, Kiyama S, Akao Y, Azuma H.
    • Journal Title

      Oncotarget

      Volume: 6 Pages: 21628-21635

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Anti-Proliferative Effect of Boron Neutron Capture Therapy in Prostate Cancer Xenograft Model2015

    • Author(s)
      Takahara K, Inamoto T, Minami K, Yoshikawa Y, Takai T, Ibuki N, Hirano H, Nomi H, Kawabata S, Kiyama S, Miyatake S, Kuroiwa T, Suzuki M, Kirihata M, Azuma H.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 9 Pages: 136981-2

    • DOI

      10.1371/journal.pone.0136981

    • NAID

      120005763435

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] テガフール・ウラシル配合剤の低用量内服が奏巧した進行膀胱神経内分泌癌(小細胞癌)の1例2015

    • Author(s)
      能見 勇人、高原 健、南 幸一郎、前之園 良一、松永 知久、吉川 勇希、辻野 拓也、平野 一、稲元 輝生、山本 員久、辻 求、木山 賢、東 治人.
    • Journal Title

      Jpn.J.Urol

      Volume: 106 Pages: 269-273

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 特発性上腰ヘルニアの1例2015

    • Author(s)
      辻野 拓也、稲元 輝生、松永 知久、内本 泰三、齋藤 賢吉、髙井 朋聡、南 幸一郎、高原 健、能見 勇人、東 治人.
    • Journal Title

      泌尿器科紀要

      Volume: 61 Pages: 449-453

    • NAID

      120005679850

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] Conversion of prostate cancer from hormone independency to dependency due to AMACR or E74-like factor inhibition2018

    • Author(s)
      Kiyoshi Takahara, Atsuhiko Yoshizawa, Masanobu Saruta, Shuhei Tomozawa, Masaru Hikichi, Kosuke Fukaya, Manabu Ichino, Naohiko Fukami, Hitomi Sasaki, Mamoru Kusaka, Ryoichi Shiroki
    • Organizer
      The 35th Korea-Japan Urological Congress
    • Related Report
      2018 Research-status Report
  • [Presentation] 再燃前立腺癌におけるAR依存性ホルモン感受性再獲得因子の検討2018

    • Author(s)
      高原 健、吉澤篤彦、猿田真庸、引地克、深谷孝介、市野 学、深見直彦、佐々木ひと美、日下守、白木良一
    • Organizer
      第68回日本泌尿器科学会中部総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 膀胱癌組織のマイクロRNAアレイから特定した、マイクロRNA群を用いた膀胱癌患者の生存予測の試み2017

    • Author(s)
      稲元 輝生、伊夫貴直和、高原 健、小林大介、市橋淳、谷口俊理、堤岳之、辻野拓也、松永 知久、吉川 勇希、齋藤 賢吉、内本 泰三、反田 直希、平野 一、能見 勇人、東 治人.
    • Organizer
      第26回泌尿器科分子・細胞研究会
    • Place of Presentation
      全労済ソレイユ( 大分県)
    • Related Report
      2016 Research-status Report
  • [Presentation] Perioperative chemotherapy and advanced disease - increasing experience and new aspects.2017

    • Author(s)
      T. Inamoto, K. Takahara , N. Ibuki , T. Takai , T. Uchimoto K. Saito , N. Tanda , Y. Yoshikawa , K. Minami , H. Hirano , H. Nomi , H. Azuma, K. Yamamoto, T. Shinbo , K. Yamamoto , Y. Narumi .
    • Organizer
      The 32nd Annual EAU Congress2017
    • Place of Presentation
      ExCeL London (イギリス・ロンドン)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Modern tools and new evidence in staging of urothelial carcinomas.2017

    • Author(s)
      T. Inamoto, K. Takahara , N. Ibuki , T. Takai , T. Uchimoto , K. Saito , N. Tanda, Y. Yoshikawa , K. Minami , H. Hirano , H. Nomi , H. Azuma .
    • Organizer
      The 32nd Annual EAU Congress2017
    • Place of Presentation
      Excel London(イギリス・ロンドン)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] MicroRNA-145 mediates the inhibitory effect of adipose-derived stem cells on androgen-independent prostate2016

    • Author(s)
      K.Takahara,T.lnamoto , N.lbuki , T.Uchimoto , K.Saito , T.Takai , N.Tanda , H.Hirano , H. Nomi , S.Kiyama, H. Azuma
    • Organizer
      European Association of Urology (EAU16)
    • Place of Presentation
      ICM Internationales Congress Center Munchen(Munchen Germany)
    • Year and Date
      2016-03-11
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 前立腺癌に対する抗腫瘍効果~癌選択的な標的粒子線治療―硼素中性子捕捉療法(BNCT)―を用いて~2016

    • Author(s)
      高原 健,稲元輝生、南 幸一郎、辻野拓也、松永知久、吉川勇希、内本泰三、齋藤賢吉、髙井朋聡、反田直希、平野 一、能見勇人、木山 賢、鈴木 実、切畑 光統、東 治人.
    • Organizer
      第25回日本泌尿器分子・細胞研究会
    • Place of Presentation
      ハイアットリージェンシー大阪(大阪府大阪市)
    • Year and Date
      2016-02-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 前立腺癌に対する硼素中性子捕捉療法(BNCT)の制癌効果2016

    • Author(s)
      高原 健,稲元 輝生、幸 一郎、吉川 勇希、高井 朋聡、平野 一、能見 勇人、木山 賢、鈴木 実、切畑光統、東 治人.
    • Organizer
      京都大学原子炉実験所 第50回学術講演会
    • Place of Presentation
      京都大学原子炉実験所(大阪府泉南郡)
    • Year and Date
      2016-01-27
    • Related Report
      2015 Research-status Report
  • [Presentation] 癌発育制御型microRNAの総量回復によるヒト膀胱癌マウス異種同所移植モデル治療2016

    • Author(s)
      稲元 輝生、谷口 高平、高原 健、岩附綾子、高井朋聡、小村和正、吉川勇希、内本泰三、齋藤賢吉、反田直希、光野絢子、南幸一郎、上原 博史、平野一、能見勇人、木山 賢、赤尾 幸博 、東 治人.
    • Organizer
      第104回日本泌尿器科学会総会
    • Place of Presentation
      仙台国際センター(宮城県)
    • Related Report
      2016 Research-status Report
  • [Presentation] 転移症例の中にも前立腺全摘除術によりベネフィットを受ける患者はいるか?2016

    • Author(s)
      高原 健.
    • Organizer
      第104回日本泌尿器科学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Related Report
      2016 Research-status Report
  • [Presentation] 前立腺癌に対する硼素中性子捕捉療法(BNCT)の制癌効果 -脂肪幹細胞ナノDDS技術を駆使した新規テーラーメイド療法を目指して-2016

    • Author(s)
      高原 健、稲元輝生、南幸一郎、吉川勇希、高井朋聡、平野 一、能見勇人、木山 賢、鈴木 実、切畑 光統、東 治人.
    • Organizer
      第104回日本泌尿器科学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Related Report
      2016 Research-status Report
  • [Presentation] Location of the tumor in upper tract urothelial carcinoma (UTUC) impacts on the presence of concomitant urothelial carcinoma of the bladder: a multi-institutional database study.2016

    • Author(s)
      Teruo Inamoto, Kiyoshi Takahara, Hideyasu Matsuyama, Kiyohide Fujimoto, Hiroaki Shiina, Shigeru Sakano, Kazuhiro Naga, Makito Miyake, Yoshihiro Tatsumi, Hiroaki Yasumoto, Haruhito Azuma.
    • Organizer
      AUA 2016 Annual Meeting
    • Place of Presentation
      San Diego Convention Center(アメリカ・サンディエゴ)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Intravesical instillation of exogenous microRNA-145 as a therapy for mouse orthotopic human bladder cancer xenograft.2016

    • Author(s)
      Teruo Inamoto, Kohei Taniguchi, Kiyoshi Takahara, Ayako Iwatsuki, Tomoaki Takai, Yuki Yoshikawa, Taizo Uchimoto, Kenkichi Saito, Naoki Tanda, Junko Kouno, Koichiro Minami, Hirofumi Uehara,Hajime Hirano, Hayahito Nomi, Satoshi Kiyama,Yukihiro Akao, Haruhito Azuma.
    • Organizer
      AUA 2016 Annual Meeting
    • Place of Presentation
      San Diego Convention Cente(アメリカ・サンディエゴ)r
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Current and future bladder sparing options for muscle invasive bladder cancer2016

    • Author(s)
      Teruo Inamoto, Kiyoshi Takahara, Haruhito Azuma.
    • Organizer
      14th Urological Association of Asia Congres2016(UAA)
    • Place of Presentation
      Sentec Singapore(マレーシア・シンガポール)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Potential new therapies for bladder cancer in the future, inspirations from the lab2016

    • Author(s)
      Teruo Inamoto, Kiyoshi Takahara, Haruhito Azuma.
    • Organizer
      14th Urological Association of Asia Congres2016(UAA)
    • Place of Presentation
      Sentec Singapore(マレーシア・シンガポール)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] ロボット支援腹腔鏡下前立腺全摘除術(RALP)の導入初期経験における検討2015

    • Author(s)
      高原 健,稲元輝生、辻野 拓也、松永 知久、吉川 勇希、内本泰三、齋藤賢吉、高井朋聡、反田直希、南幸一郎、平野 一、能見勇人、木山 賢、東 治人.
    • Organizer
      第28回日本内視鏡外科学会総会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2015-12-10
    • Related Report
      2015 Research-status Report
  • [Presentation] 当科におけるロボット支援腹腔鏡下前立腺全摘除術(RALP)の初期経験2015

    • Author(s)
      高原 健,稲元 輝生、髙井 朋聡、齋藤 賢吉、内本 泰三、反田 直希、平野 一、能見 勇人、木山 賢、東 治人.
    • Organizer
      第29回日本泌尿器内視鏡学会総会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2015-11-19
    • Related Report
      2015 Research-status Report
  • [Presentation] 脂肪幹細胞由来miR-145による前立腺癌細胞増殖抑制効果の検討2015

    • Author(s)
      高原 健,稲元輝生、辻野 拓也、松永 知久、吉川 勇希、内本泰三、齋藤賢吉、高井朋聡、反田直希、平野 一、能見勇人、木山 賢、東 治人.
    • Organizer
      第65回日本泌尿器科学会中部総会
    • Place of Presentation
      長良川国際会議場(岐阜県岐阜市)
    • Year and Date
      2015-10-23
    • Related Report
      2015 Research-status Report
  • [Presentation] ロポット支援腹腔鏡下前立腺全摘除術(RALP) の初期経験~ アシスタントポート2015

    • Author(s)
      高原 健,稲元 輝生、南 幸一郎、内本 泰三、齋藤 賢吉、高井 朋聡、反田 直希、平野 一、能見 勇人、木山 賢、東 治人.
    • Organizer
      第103回日本泌尿器科学会総会
    • Place of Presentation
      ANAクラウンプラザホテル金沢(石川県金沢市)
    • Year and Date
      2015-04-18
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2021-02-19  

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