• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of a novel method for the regeneration of the cavernous body by regulating micro RNA expression

Research Project

Project/Area Number 15K10618
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionThe University of Tokyo

Principal Investigator

Nishimatsu Hiroaki  東京大学, 医学部附属病院, 登録診療員 (60251295)

Co-Investigator(Kenkyū-buntansha) 鈴木 越  聖マリアンナ医科大学, 医学研究科, 講師 (40313134)
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords動脈硬化 / プラーク内出血 / 炎症性サイトカイン / エピジェネティックス / IL-1beta siRNA / ApoE欠損マウス / マイクロRNA / 器質性勃起障害
Outline of Final Research Achievements

The rupture of plaques in atherosclerotic lesion causes the obstruction of the coronary artery, leading to acute myocardial infarction. Therefore, it is pivotal to establish a method to prevent plaque rupture. It is well known that plaques with thin-cap fibroatheroma is vulnerable to damages and often rupture. Intraplaque hemorrhage (IPH) is regarded as a major factor that triggers the instability and vulnerability of plaques. We found that the proinflammatory cytokine interleukin-1beta(IL-1beta)is implicated in IPH using a mouse model of atherosclerosis. We also found that IL-1beta inhibits normal angiogenesis and stimulates immature angiogenesis, which results in the leakage of erythrocytes from new vessels in the plaques and IPH.

Academic Significance and Societal Importance of the Research Achievements

急性心筋梗塞は代表的な心血管病であり発症を防ぐことは国民の健康寿命を延ばすために重要である。今回我々はマウスのモデルではあるが炎症性サイトカインであるinterleukin-1beta(IL-1beta)の発現を抑制すると急性心筋梗塞の発症を予防できる可能性を示すことができた。今後IL-1betaの阻害薬あるいは活性阻害抗体薬などが開発されることを期待したい。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (8 results)

All 2018 2016 2015

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 2 results,  Acknowledgement Compliant: 4 results) Book (1 results)

  • [Journal Article] Endogenous interleukin-1beta is implicated in intraplaque hemorrhage in apolipoprotein e gene null mice.2018

    • Author(s)
      Suzuki E, Imuta H, Fujita D, Takahashi M, Oba S, Kiyosue A, Nishimatsu H.
    • Journal Title

      Circ J.

      Volume: 82 Pages: 1130-1138

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Therapeutic effects of mesenchymal stem cell-derived exosomes in cardiovascular disease.2018

    • Author(s)
      Suzuki E, Fujita D, Takahashi M, Oba S, Nishimatsu H.
    • Journal Title

      Advances in experimental medicine and biology.

      Volume: 998 Pages: 179-185

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Stem cell-derived exosomes as a therapeutic tool for cardiovascular disease.2016

    • Author(s)
      Suzuki E, Fujita D, Takahashi M, Oba S, Nishimatsu H.
    • Journal Title

      World journal of stem cells.

      Volume: 8 Pages: 297-305

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Adult stem cells as a tool for kidney regeneration.2016

    • Author(s)
      Suzuki E, Fujita D, Takahashi M, Oba S, Nishimatsu H.
    • Journal Title

      World J Nephrol.

      Volume: 5 Pages: 43-52

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Impaired response of regulator of Gαq signaling-2 mRNA to angiotensin II and hypertensive renal injury in Dahl salt-sensitive rats.2016

    • Author(s)
      Wu Y, Takahashi H, Suzuki E, Kruzliak P, Soucek M, Uehara Y.
    • Journal Title

      Hypertens Res.

      Volume: 39(4) Issue: 4 Pages: 210-6

    • DOI

      10.1038/hr.2015.132

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neuromedin B Restores Erectile Function by Protecting the Cavernous Body and the Nitrergic Nerves from Injury in a Diabetic Rat Model.2015

    • Author(s)
      Nishimatsu H, Suzuki E, Saito Y, Niimi A, Nomiya A, Yamada D, Homma Y.
    • Journal Title

      PLoS One.

      Volume: 10(7) Issue: 7 Pages: e0133874-e0133874

    • DOI

      10.1371/journal.pone.0133874

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Adipose tissue-derived stem cells as a therapeutic tool for cardiovascular disease.2015

    • Author(s)
      Suzuki E, Fujita D, Takahashi M, Oba S, Nishimatsu H.
    • Journal Title

      World J Cardiol.

      Volume: 7(8) Issue: 8 Pages: 454-65

    • DOI

      10.4330/wjc.v7.i8.454

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Book] Erectile dysfunction and chronic kidney disease and renal transplantation2016

    • Author(s)
      Etsu Suzuki, Hiroaki Nishimatsu, Yukio Homma
    • Publisher
      Nova science publishers, NY
    • Related Report
      2016 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi