The ameliorative potential of tamsulosin on bladder function in an established rat model of chronic pelvic ischemia

• Project/Area Number: 15K10621
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: University of Yamanashi
• Principal Investigator: SAWADA Norifumi 山梨大学, 大学院総合研究部, 講師 (70402055)
• Co-Investigator(Renkei-kenkyūsha): KIRA Satoru 山梨大学, 大学院総合研究部, 助教 (10530115) ; TAKEDA Masayuki 山梨大学, その他部局等, 理事 (80197318)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 慢性虚血 / 低活動膀胱 / α１阻害剤 / 膀胱機能 / α１阻害薬 / α１受容体阻害剤 / タムスロシン / Sprague-Dawleyラット / α１ブロッカー / SDラット

Outline of Final Research Achievements

The atherosclerotic obstructive changes will have consequences for the distal vasculature and LUTS blood flow.Recently overactive bladder is supposed to advance to underactive bladder due to ischemic insult.To mimic the elder LUTS patient,we delayed administering tamsulosin for 8 weeks from the establishment of chronic pelvic ischemia(CPI)rat model and checked the improving effect for voiding dysfunction.The animals treated with tamsulosin showed an improved bladder function presumably due to the increased bladder flow.If these results are valid for the bladder dysfunction in humans,they support that the treatment of tamsulosin will improve the elderly LUTS patients.