Bone marrow-derived cell structures reconstructs functional urinary bladders
| Project/Area Number |
15K10622
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 膀胱再生 / 骨髄由来細胞 / バイオ3Dプリンター / 放射線照射傷害膀胱 / 下部尿路再生医療 / 間葉系幹細胞 / 細胞凝集体 / ラット / スフェロイド / 積層型構造体 / ３Dバイオプリンター |
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| Outline of Final Research Achievements |
In urology, bladder dysfunctions, which can occur as a result of various diseases such as radiation cystitis, or interstitial cystitis, are considered to be refractory lower urinary tract symptoms (LUTS). Novel treatments for the bladder dysfunctions are urgently needed. Previously, we showed that bone marrow-derived cells have the potential to reconstruct functional urinary bladders by two methods. One was the direct-injection of single cells and the other was patch-transplantation of cell sheets. Both methods successfully reconstructed functional bladders. However, there are some limitations for each method. To overcome these limitations, we have attempted to biofabricate bone marrow-derived cell structures with 3D bioprinting robot system. We determined if the transplanted biofabricated structures could reconstruct functional bladders.
In this study, we showed that the biofabricated structures have great potential to treat patients with serious LUTS due to damaged bladders.
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Report
(4 results)
Research Products
(27 results)
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[Presentation] 下部尿路再生医療研究2015
Author(s)
今村哲也
Organizer
第22回日本排尿機能学会
Place of Presentation
北海道 札幌市 京王プラザホテル札幌
Year and Date
2015-09-09
Related Report
Invited
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