| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
In urology, bladder dysfunctions, which can occur as a result of various diseases such as radiation cystitis, or interstitial cystitis, are considered to be refractory lower urinary tract symptoms (LUTS). Novel treatments for the bladder dysfunctions are urgently needed. Previously, we showed that bone marrow-derived cells have the potential to reconstruct functional urinary bladders by two methods. One was the direct-injection of single cells and the other was patch-transplantation of cell sheets. Both methods successfully reconstructed functional bladders. However, there are some limitations for each method. To overcome these limitations, we have attempted to biofabricate bone marrow-derived cell structures with 3D bioprinting robot system. We determined if the transplanted biofabricated structures could reconstruct functional bladders.
In this study, we showed that the biofabricated structures have great potential to treat patients with serious LUTS due to damaged bladders.
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