A comprehensive study of the establishment of urolithiasis prophylaxis from both genetic factors and environmental factors
| Project/Area Number |
15K10626
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Nagoya City University |
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Principal Investigator |
Ito Yasunori 名古屋市立大学, 大学院医学研究科, 研究員 (70295608)
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| Co-Investigator(Kenkyū-buntansha) |
郡 健二郎 名古屋市立大学, その他部局等, 学長 (30122047)
戸澤 啓一 名古屋市立大学, 大学院医学研究科, 教授 (40264733)
安井 孝周 名古屋市立大学, 大学院医学研究科, 教授 (40326153)
岡田 淳志 名古屋市立大学, 大学院医学研究科, 講師 (70444966)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 尿路結石 / メタボリックシンドローム / 肥満 / 予防 / PPAR / オステオポンチン / 尿路結石症 / 酸化ストレス / OPN KOマウス / DNAマイクロアレイ / transgenic mouse / PPARγアゴニスト / アディポサイトカイン / OPNノックアウトマウス / トランスジェニックマウス |
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| Outline of Final Research Achievements |
We have reported that urolithiasis is similar to the onset mechanism of metabolic syndrome. Therefore, in this research, we pushed through these studies, and aimed at establishing a method for preventing urolithiasis prevention, we conducted research from genetic factors and environmental factors.1. Approach from genetic factors: We have found that nicotinamide nucleotide transhydrogenase (Nnt) gene is one of the factors related to the stone formation from the study between subgenera of the mouse.
2. Approach from environmental factors: PPAR-gamma agonist (thiazolidinedione) was administered to stone model rats. It has been reported that it has an inhibitory effect on the formation of calculus accompanied by an altered expression of adipocytokine. The metabolic syndrome forms urinary stone via oxidative stress elevation.
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Report
(4 results)
Research Products
(12 results)
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[Presentation] The role of M1/M2 macrophages for CaOx stone and Randall’s plaque formation.2016
Author(s)
Taguchi Kazumi, Okada Atsushi, Hamamoto Shuzo, Unno Rei, Kamisawa Hideyuki, Naiki Taku, Ando Ryosuke, Umemoto Yukihiro, Itoh Yasunori, Tozawa Keiichi, Kohri Kenjiro, Yasui Takahiro
Organizer
The 31th Annual Congress of the European Association of Urology
Place of Presentation
Munich(Germany)
Year and Date
2016-03-11
Related Report
Int'l Joint Research
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[Presentation] Administration of the selective alpha 1A adrenoceptor antagonist silodosin facilitates expulsion of size 5 - 10 mm distal ureteral stones, as compared to control.2015
Author(s)
Itoh Yasunori, Okada Atsushi, Taguchi Kazumi, Hirose Yasuhiko, Fujii Yasuhiro, Kobayashi Takahiro, Usami Masayuki, Hamamoto Shuzo, Hirose Masahito, Yasui Takahiro, Tozawa Keiichi, Sasaki Shoichi, Hayashi Yutaro, Kohri Kenjiro
Organizer
American Urological Association Annual Meeting 2015
Place of Presentation
New Orleans(USA)
Year and Date
2015-05-15
Related Report
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