| Project/Area Number |
15K10626
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Nagoya City University |
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Principal Investigator |
Ito Yasunori 名古屋市立大学, 大学院医学研究科, 研究員 (70295608)
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| Co-Investigator(Kenkyū-buntansha) |
郡 健二郎 名古屋市立大学, その他部局等, 学長 (30122047)
戸澤 啓一 名古屋市立大学, 大学院医学研究科, 教授 (40264733)
安井 孝周 名古屋市立大学, 大学院医学研究科, 教授 (40326153)
岡田 淳志 名古屋市立大学, 大学院医学研究科, 講師 (70444966)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 尿路結石 / メタボリックシンドローム / 肥満 / 予防 / PPAR / オステオポンチン / 尿路結石症 / 酸化ストレス / OPN KOマウス / DNAマイクロアレイ / transgenic mouse / PPARγアゴニスト / アディポサイトカイン / OPNノックアウトマウス / トランスジェニックマウス |
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| Outline of Final Research Achievements |
We have reported that urolithiasis is similar to the onset mechanism of metabolic syndrome. Therefore, in this research, we pushed through these studies, and aimed at establishing a method for preventing urolithiasis prevention, we conducted research from genetic factors and environmental factors.1. Approach from genetic factors: We have found that nicotinamide nucleotide transhydrogenase (Nnt) gene is one of the factors related to the stone formation from the study between subgenera of the mouse.
2. Approach from environmental factors: PPAR-gamma agonist (thiazolidinedione) was administered to stone model rats. It has been reported that it has an inhibitory effect on the formation of calculus accompanied by an altered expression of adipocytokine. The metabolic syndrome forms urinary stone via oxidative stress elevation.
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