A single center prospective observational study for the purpose of non-invasive diagnosis of post-transplant IgA nephropathy in the renal transplant recipients
| Project/Area Number |
15K10643
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kagawa University |
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Principal Investigator |
Sofue Tadashi 香川大学, 医学部附属病院, 講師 (80452671)
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| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI HITOSHI 順天堂大学, 医学部, 准教授 (10468572)
OHSAKI HIROYUKI 神戸大学, 医学部保健学科, 准教授 (80438291)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 腎移植 / IgA腎症 / 再発腎炎 / 糖鎖異常IgA1 / 細胞老化 / 移植腎生検 / P16 / マージナルドナー / 生体腎移植 / バイオマーカー |
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| Outline of Final Research Achievements |
Non-invasive methods of diagnosis of post-transplant IgA deposition (IgAD) in the allograft using serological and pathological biomarkers are being developed. Possible serum biomarkers include serum galactose-deficient IgA1 (Gd-IgA1), Gd-IgA1-specific IgG and Gd-IgA1-specific IgA, and its immune complexes. Immunofluorescence analysis using Gd-IgA1 monoclonal antibody may provide a pathological biomarker. These serological and pathological biomarkers may be suitable for the characterisation of the stage of IgAD. However, there is insufficient information regarding whether serological and pathological biomarkers can predict the progression of asymptomatic IgAD to symptomatic IgA nephropathy (IgAN). We propose that the pathogenesis of IgAN can be defined through the clinical study of IgAD in the allograft using protocol biopsies conducted by nephrologists involved in clinical kidney transplantation.
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Report
(4 results)
Research Products
(46 results)
