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Anti-CD20 antibody and anti-TNF alpha antibody of kidney transplantation in a mouse model

Research Project

Project/Area Number 15K10648
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionKitasato University

Principal Investigator

ISHII DAISUKE  北里大学, 医学部, 講師 (10327413)

Co-Investigator(Kenkyū-buntansha) 吉田 一成  北里大学, 医学部, 教授 (10174921)
川村 瑞穂  北里大学, 医学部, 助教 (20623135)
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords腎移植 / 拒絶反応 / マウス / マウス腎移植 / マウス心臓移植 / 腎臓移植 / 抗CD20モノクロナール / 抗体関連型拒絶反応 / 抗CD20モノクローナル
Outline of Final Research Achievements

For long-term survival in renal transplantation, suppression of antibody production to the graft and treatment of antibody-related rejection are important. Preparation of antibody-related rejection model in mice and mouse kidney transplantation for the purpose of clarifying the mechanism of immunosuppression using anti-CD20 monoclonal antibody and anti-inflammatory TNF monoclonal antibody as novel therapeutic agents in the treatment Although the model preparation was examined, the supply of the mouse kidney transplantation model was not stable, and it was difficult to study the mechanism of immunosuppression.

Academic Significance and Societal Importance of the Research Achievements

腎移植後の抗体関連型拒絶反応は移植片廃絶の大きな要因として問題となっているがいまだ明確な治療ガイドラインは存在せず、その動物実験モデルに関してもまだ確立されたものはない。今回我々はマウスにおける心臓、腎臓移植の抗体関連型拒絶反応モデルの作成とその拒絶反応に対する抗CD20モノクローナル抗体(Rituximab)による治療に関しての動物モデルを作成し今後の抗体関連型拒絶反応の治療に対する機序の解明を目的としたが動物モデルの安定した供給が困難であったため抗体を使用した検討ができておらず腎移植マウス作成方法に関して再考する必要があると考えられた。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (29 results)

All 2019 2018 2017 2016 2015

All Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Open Access: 6 results) Presentation (20 results) (of which Int'l Joint Research: 6 results,  Invited: 1 results) Book (1 results)

  • [Journal Article] Robot-assisted laparoscopic radical cystectomy is a safe and effective procedure for patients with bladder cancer compared to laparoscopic and open surgery: Perioperative outcomes of a single-center experience.2019

    • Author(s)
      Matsumoto K, Tabata KI, Hirayama T, Shimura S, Nishi M, Ishii D, Fujita T, Iwamura M.
    • Journal Title

      Asian J Surg

      Volume: 42(1) Pages: 189-196

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy and safety of sunitinib in elderly patients with advanced renal cell carcinoma.2018

    • Author(s)
      Fujita T, Hirayama T, Ishii D, Matsumoto K, Yoshida K, Iwamura M.
    • Journal Title

      Molecular and Clinical Oncology

      Volume: 9(4) Pages: 394-398

    • DOI

      10.3892/mco.2018.1684

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Peritoneal dialysis catheter insertion surgery and management.2018

    • Author(s)
      Yoshida K, Ishii D
    • Journal Title

      J Vasc Access

      Volume: Mar 1 Issue: 1_suppl Pages: 1-3

    • DOI

      10.1177/1129729818762989

    • Related Report
      2017 Research-status Report
    • Open Access
  • [Journal Article] Prognostic effect of serum C-reactive protein kinetics on advanced renal cell carcinoma treated with sunitinib.2017

    • Author(s)
      Fujita T, Tabata KI, Ishii D, Matsumoto K, Yoshida K, Iwamura M.
    • Journal Title

      Mol Clin Oncol.

      Volume: 6(5) Issue: 5 Pages: 691-696

    • DOI

      10.3892/mco.2017.1201

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Robot-assisted laparoscopic radical cystectomy is a safe and effective procedure for patients with bladder cancer compared to laparoscopic and open surgery: Perioperative outcomes of a single-center experience.2017

    • Author(s)
      Matsumoto K, Tabata KI, Hirayama T, Shimura S, Nishi M, Ishii D, Fujita T, Iwamura M.
    • Journal Title

      Asian J Surg

      Volume: Dec 15 Issue: 1 Pages: 189-196

    • DOI

      10.1016/j.asjsur.2017.11.002

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of Lymphadenectomy During Radical Nephroureterectomy in Locally Advanced Upper Tract Urothelial Carcinoma.2017

    • Author(s)
      Ikeda M, Matsumoto K, Sakaguchi K, Ishii D, Tabata KI, Kurosawa K, Urakami S, Okaneya T, Iwamura M.
    • Journal Title

      Clin Genitourin Cancer.

      Volume: 15(5) Issue: 5 Pages: 556-562

    • DOI

      10.1016/j.clgc.2017.04.004

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 拒絶反応2016

    • Author(s)
      吉田一成、石井大輔
    • Journal Title

      腎と透析

      Volume: 80 Pages: 692-695

    • Related Report
      2016 Research-status Report
  • [Journal Article] Anti-huCD20 Antibody Therapy for Antibody-Mediated Rejection of Renal Allografts in a Mouse Model2015

    • Author(s)
      T. Abe, D. Ishii, V. Gorbacheva, N. Kohei, H. Tsuda, T. Tanaka, N. Dvorina, N. Nonomura, S. Takahara, A. Valujskikh, W. M. Baldwin III, R. L. Fairchild
    • Journal Title

      AMERICAN JOURNAL OF TRANSPLANTATION

      Volume: 15 Issue: 5 Pages: 1192-1204

    • DOI

      10.1111/ajt.13150

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 当院での導入期エベロリムス併用プロトコールの検討2018

    • Author(s)
      石井大輔 綿貫翔 天野統之 志村壮一郎 遠藤忠雄 岩村正嗣 澤田彩 竹内康雄 吉田一成
    • Organizer
      第54回日本移植学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 腎移植後の腹腔内PTLD2例2018

    • Author(s)
      澤田彩、石井大輔、西山景子、綿貫翔、天野統之、志村壮一郎、岩村正嗣 竹内康雄、鎌田浩稔、吉田一成
    • Organizer
      第29回神奈川移植医学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 移植後早期に動脈閉塞を来した生体間腎移植症例の経験2018

    • Author(s)
      石井大輔、天野統之、立花貴史、志村壮一郎、野口文乃、岩村正嗣 、竹内和博、竹内康雄、吉田一成、佐々木秀郎、力石辰也
    • Organizer
      第34回腎移植・血管外科研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 小腸穿孔により腸切除を要した腎移植後小腸原発PTLDの一例2018

    • Author(s)
      石井大輔、綿貫翔、志村壮一郎、天野統之、岩村正嗣、鎌田浩稔、筒井敦子、吉田一成
    • Organizer
      第27回腎不全外科研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 当院の先行的腎移植と短期透析後腎移植の検討2018

    • Author(s)
      石井大輔、天野統之、立花貴史、川村瑞穂、平山貴博、藤田哲夫、岩村正嗣、吉田一成
    • Organizer
      第106日本泌尿器科学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 当院の先行的腎移植と短期透析後腎移植の検討2018

    • Author(s)
      石井大輔、天野統之、立花貴史、川村瑞穂、平山貴博、藤田哲夫、岩村正嗣、吉田一成
    • Organizer
      第106回日本泌尿器科学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 腎移植後直後からTMA病態を発症し、改善と再燃を繰り返し腎機能廃絶へ至った一例2017

    • Author(s)
      竹内康雄、石井大輔、 吉田一成
    • Organizer
      相模原TMA症例検討会
    • Place of Presentation
      神奈川県相模原市
    • Year and Date
      2017-03-31
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 2型糖尿病患者に対する腎移植の診療体制と臨床的成績の検討2017

    • Author(s)
      川村瑞穂 石井大輔 萩原正博 立花貴史 野口文乃 井村夕姫 池田成江 吉田朋子 竹内康雄 吉田一成 岩村正嗣
    • Organizer
      第50回日本臨床腎移植学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 当院での腹腔鏡下腎部分切除術とロボット支援下腎部分切除術の比較2017

    • Author(s)
      石井大輔 西 盛宏 藤田哲夫 小林桃子 勝又洋樹 名木渉人 立花貴史  川村瑞穂 松本和将 吉田一成 岩村正嗣
    • Organizer
      第31回日本泌尿器内視鏡学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 移植腎動脈解離に対してPTAが奏功した高齢夫婦間生体腎移植の1例2017

    • Author(s)
      高橋遼、石井大輔、川村瑞穂、立花貴史、阿部哲也 平山貴博、松本和将、岩村正嗣、竹内康雄、吉田一成
    • Organizer
      第26回日本腎不全外科研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] HIV陽性生体腎移植における免疫抑制療法の経験2017

    • Author(s)
      石井大輔 立花貴史 藤田哲夫 高橋遼 本間友香理 竹内康雄 和田達彦 岩村正嗣 吉田一成
    • Organizer
      第2回TDM-QC研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] OGTT CAN PREDICT ONSET OF NODAT IN KIDNEY TRANSPLANTATION2017

    • Author(s)
      Mizuho Kawamua, Kazunari Yoshida, Tomoko Yoshida, Daisuke Ishii, Fumino Noguchi, Akinori Hayashi, Yasuo Takeuchi, Masayoshi Shichiri, Masatsugu Iwamura
    • Organizer
      5th Congress of the Asian Society of Transplantation
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] A clinical study of kidney transplantation for diabetic nephropathy at Kitasato University Hospital.2017

    • Author(s)
      Daisuke Ishii, Yoshida K, Miyasaka R, Tachibana T, Kawamura M,Hirayama T, Takeuchi Y, Iwamura M.
    • Organizer
      Asian Transplantation Week 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Long period follow-up of renal function of living renal donor.2016

    • Author(s)
      Kazunari Yoshida, Daisuke Ishii, Yasuo Takeuchi, Fumino Noguchi, Masae Ikeda, Miki Tanaka, Rie Iriki, Haruki Wakai
    • Organizer
      26th INTERNATIONAL CONGRESS OF THE TRANSPLANTATION SOCIETY
    • Place of Presentation
      Hong Kong,中国
    • Year and Date
      2016-08-20
    • Related Report
      2016 Research-status Report
  • [Presentation] 部分腎摘マウスのNestin誘導2016

    • Author(s)
      河原克雅、安岡有紀子、 福田英一、石井大輔、 岩村正嗣、野々口博史
    • Organizer
      第59回日本腎臓学会学術総会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2016-06-17
    • Related Report
      2016 Research-status Report
  • [Presentation] EVEROLIMUS, TAC-ER AND MMF DE NOVO RENAL TRANSPLANT RESULTED GOOD GRAFT FUNCTION2015

    • Author(s)
      Kazunari Yoshida, Daisuke Ishii, Yasuo Takeuchi, Haruki Wakai, Dai Kouguchi, Fumino Noguchi, Masae Ikeda, Miki Tanaka
    • Organizer
      17th Congress of the European Society for Organ Transplantation
    • Place of Presentation
      Square Brussels Meeting Centre(Brussels, Belgium )
    • Year and Date
      2015-09-16
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] BUILDING A BALANCED TRUST RELATIONSHIP BETWEEN THE RENAL TRANSPLANT PATIENT ASSOCIATION AND RENAL TRANSPLANT MEDICAL PROFESSIONALS2015

    • Author(s)
      MASAE IKEDA, DAISUKE ISHII , SYUHEI HIRANO, FUMINO NOGUCH, TOMOKO YOSHIDA MASATOSHI SAKAMOTO, KAZUYUKI KOMAGATA , MASATSUGU IWAMURA, KAZUNARI YOSHIDA
    • Organizer
      17th Congress of the European Society for Organ Transplantation
    • Place of Presentation
      Square Brussels Meeting Centre(Brussels, Belgium )
    • Year and Date
      2015-09-13
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 当院における腎移植後の抗HLA抗体検査についての検討2015

    • Author(s)
      石井大輔、萩原正博、小林健太郎、平野修平、松本和将、若井陽希、池田成江、野口文乃、入木季恵、吉田一成、岩村正嗣
    • Organizer
      第24回日本組織適合性学会大会
    • Place of Presentation
      ホテルレイクビュー水戸 (茨城県水戸市)
    • Year and Date
      2015-09-10
    • Related Report
      2015 Research-status Report
  • [Presentation] Long-Term Follow-Up Of Anti-HLA Antibodies Post Kidney Transplantation Using With Flow-Panel Reactive Antibody2015

    • Author(s)
      Daisuke Ishii,Kentaro Kobayashi,Shuhei Hirano,Takahiro Hirayama,Ken-Ichi Tabata,Haruki Wakai,Yasuo Takeuchi,Fumino Noguchi,Masae Ikeda,Msatsugu Iwamura,Kazunari Yoshida
    • Organizer
      14th Congress of the Asian Society of Transplantation
    • Place of Presentation
      Suntec Singapore Convention & Exhibition Centre(Singapore )
    • Year and Date
      2015-08-25
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Survey On Anxiety And Behavior For Overseas Travel Of Renal Transplant Patients2015

    • Author(s)
      Masae Ikeda,Daisuke Ishii,Fumino Noguchi,Miki Tanaka,Masatsugu Iwamura,Kazunari Yoshida
    • Organizer
      14th Congress of the Asian Society of Transplantation
    • Place of Presentation
      Suntec Singapore Convention & Exhibition Centre(Singapore )
    • Year and Date
      2015-08-24
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Book] 腎と透析診療指針20162016

    • Author(s)
      吉田一成、石井大輔
    • Total Pages
      804
    • Publisher
      東京医学社
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2020-03-30  

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