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Activin Production in Amniotic Cells - Research to Provide New Information for the Development of a FIRS Therapy -

Research Project

Project/Area Number 15K10658
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionGunma University

Principal Investigator

ABE Yumiko  群馬大学, 大学院保健学研究科, 准教授 (70261857)

Co-Investigator(Kenkyū-buntansha) 峯岸 敬  群馬大学, その他部局等, 理事 (00209842)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords羊膜細胞 / アクチビン / インヒビン / フォリスタチン / FSTL-3 / FIRS / 絨毛膜羊膜炎 / 炎症性サイトカイン / TNF-α / IL-1β
Outline of Final Research Achievements

Fetal Inflammatory Response Syndrome (FIRS) develops when inflammation extends to the amnion and the umbilical cord in chorioamnionitis. The survival rate is reported to increase in experimental animals with sepsis as a result of the administration of an activin binding protein which negates the activity of activin. Therefore, we studied the effects of inflammatory cytokines on the synthesis of activin and negative regulators of activin in human amniotic cells. Inflammatory cytokines predominantly stimulated the synthesis of activin compared to that of negative regulators of activin. Some of the signal transduction pathways involved in increased activin synthesis by the inflammatory cytokine TNF-alpha were also elucidated in this study. From these results, the inhibition of the synthesis of activin in human amniotic cells and the administration of negative regulators of activin appear to be exploitable for the development of a new FIRS therapy.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (20 results)

All 2018 2017 2016 2015 Other

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 3 results) Presentation (12 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Familial campomelic dysplasia due to maternal germinal mosaicism2018

    • Author(s)
      Higeta D, Yamaguchi R, Takagi T, Nishimura G, Sameshima K, Saito K, Minegishi T
    • Journal Title

      Congenit Anom (Kyoto)

      Volume: Mar 14 Issue: 6 Pages: 1-4

    • DOI

      10.1111/cga.12279

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prevalence of rear seat belt use among pregnant women in a suburban area of Japan.2018

    • Author(s)
      Ogawa S, Shinozaki H, Hayashi K, Itoh M, Soda M, Kameda T, Ozawa K, Yokota H, Kamioka K, Minegishi T.
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 44 Issue: 1 Pages: 117-123

    • DOI

      10.1111/jog.13468

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] アクチビン・インヒビンによる生殖制御機構2017

    • Author(s)
      安部由美子、峯岸敬
    • Journal Title

      内分泌・糖尿病・代謝内科

      Volume: 44 Pages: 7-14

    • Related Report
      2016 Research-status Report
  • [Journal Article] 卵巣チョコレート嚢胞内3-Ethylpyridine(CD44とTenascinのインヒビター)注入療法2016

    • Author(s)
      五十嵐 敏雄, 五十嵐 茂雄, 安部 由美子, 梁 善光, 五十嵐 正雄
    • Journal Title

      日本エンドメトリオーシス学会会誌

      Volume: 37 Pages: 125-128

    • Related Report
      2016 Research-status Report
    • Open Access
  • [Journal Article] ゴナドトロピン・エストロジェン2016

    • Author(s)
      安部由美子、峯岸敬
    • Journal Title

      ホルモンと臨床

      Volume: 62 Pages: 291-296

    • Related Report
      2015 Research-status Report
  • [Presentation] Effect of Interleukin-1β on Expression of Activin βA-subunit mRNA in Human Amniotic Epithelial Cells2017

    • Author(s)
      Norio Nakagawa, Takumi Nagasawa, Yumiko Abe, Daisuke Higeta, Takashi Kameda, Hiroshi Kishi, Takashi Minegishi
    • Organizer
      The 4th World Congress of Reproductive Biology (WCRB2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] GPIHBP1 Levels are Elevated in Hypertensive Disorders of Pregnancy2017

    • Author(s)
      Hisanobu Sadakata, Tetsuo Machida, Kazuya Miyashita, Katsuyuki Nakajima, Masami Murakami, Takashi Kameda, Hiroshi Kishi, Takashi Minegishi, Anne P. Beigneux, Stephen G. Young, Yumiko Abe
    • Organizer
      The 29th World Congress of World Association of Societies of Pathology and Laboratory Medicine (WASPaLM2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 羊膜上皮細胞と羊膜間葉系細胞におけるActivin A産生の相違2016

    • Author(s)
      岡林武志、新井菜津子、蓮子小百合、森田晶人、日下田大輔、星野正道、井上真紀、亀田高志、峯岸敬、長谷川喜久、安部由美子
    • Organizer
      第41回日本比較内分泌学会
    • Place of Presentation
      北里大学相模原キャンパス(相模原市)
    • Year and Date
      2016-12-09
    • Related Report
      2016 Research-status Report
  • [Presentation] Tetタンパクは転写因子Nr2f2のプロモーターを脱メチル化することによりES細胞の多能性を維持する2016

    • Author(s)
      堀居 拓郎, 森田 純代, 木村 美香, 寺脇 直美, 木村 博信, 末武 勲, 田嶋 正二, 安部 由美子, 畑田 出穂
    • Organizer
      第109回日本繁殖生物学会大会
    • Place of Presentation
      麻布大学(相模原市)
    • Year and Date
      2016-09-11
    • Related Report
      2016 Research-status Report
  • [Presentation] Secretion of free activin A from human amniotic epithelial cells2016

    • Author(s)
      Okabayashi T, Arai N, Hasuko S, Higeta D, Kameda T, Minegishi T, Sadakata H, Hasegawa Y, Abe Y
    • Organizer
      International Symposium on Pituitary Gland and Related Systems 2016
    • Place of Presentation
      East-West Center, University of Hawaii at Manoa (Honolulu, Hawaii)
    • Year and Date
      2016-09-02
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 卵巣チョコレート嚢胞内3EP(CD44とTenascinのインヒビター)注入療法2016

    • Author(s)
      五十嵐敏雄、五十嵐茂雄、安部由美子、梁善光、五十嵐正雄
    • Organizer
      第37回日本エンドメトリオーシス学会学術講演会
    • Place of Presentation
      ホテル日航熊本(熊本県・熊本市)
    • Year and Date
      2016-01-23
    • Related Report
      2015 Research-status Report
  • [Presentation] 新しく究明した子宮内膜症の原因物質CD44とTenascinを抑制する新しい子宮内膜症治療薬3-Ethylpyridine (3EP)の発見2016

    • Author(s)
      五十嵐正雄、五十嵐敏雄、五十嵐茂雄、安部由美子、梁善光、峯岸敬、石本一也
    • Organizer
      第37回日本エンドメトリオーシス学会学術講演会
    • Place of Presentation
      ホテル日航熊本(熊本県・熊本市)
    • Year and Date
      2016-01-23
    • Related Report
      2015 Research-status Report
  • [Presentation] Comparison of Activin A Synthesis between Amniotic Epithelial Cells and Amniotic Mesenchymal Cells Obtained from Human Amniotic Membranes2015

    • Author(s)
      Takeshi Okabayashi, Kazuko Watanabe, Hisanobu Sadakata, Takashi Kameda, Takashi Minegishi, Yumiko Abe
    • Organizer
      CompBiol 2015広島大会 第40回日本比較内分泌学会・第37回日本比較生理生化学会 合同大会
    • Place of Presentation
      JMSアステールプラザ(広島県・広島市)
    • Year and Date
      2015-12-12
    • Related Report
      2015 Research-status Report
  • [Presentation] エンブリオロジストとして最低限必要なDNA・遺伝子の基礎的知識2015

    • Author(s)
      安部由美子
    • Organizer
      第1回エンブリオロジストのためのPGS/PGDを学ぶ会
    • Place of Presentation
      群馬パース大学 1号館8階PAZホール(群馬県・高崎市)
    • Year and Date
      2015-09-05
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] ヒト羊膜細胞におけるactivin Aとactivin Bの遺伝子発現2015

    • Author(s)
      渡邉和子、山中行義、岡林武志、定方久延、亀田高志、峯岸敬、安部由美子
    • Organizer
      第30回日本下垂体研究会学術集会
    • Place of Presentation
      宇奈月国際会館セレネ(富山県・黒部市)
    • Year and Date
      2015-08-05
    • Related Report
      2015 Research-status Report
  • [Presentation] ES細胞の初期分化にはTetによるNr2f2プロモーター領域の脱メチル化が必要である2015

    • Author(s)
      堀居拓郎、森田純代、木村美香、小林遼平、田村大樹、木村博信、末武勲、田嶋正二、安部由美子、畑田出穂
    • Organizer
      第9回日本エピジェネティクス研究会年会
    • Place of Presentation
      学術総合センター一ツ橋講堂(東京都・千代田区)
    • Year and Date
      2015-05-25
    • Related Report
      2015 Research-status Report
  • [Presentation] ヒト羊膜細胞におけるTNF-αのactivin A遺伝子発現促進作用2015

    • Author(s)
      山中行義、大庭僚将、渡邉和子、定方久延、亀田高志、峯岸敬、水谷哲也、宮本薫、安部由美子
    • Organizer
      第88回日本内分泌学会学術総会
    • Place of Presentation
      ホテルニューオータニ東京(東京都・千代田区)
    • Year and Date
      2015-04-24
    • Related Report
      2015 Research-status Report
  • [Book] 基礎からわかる女性内分泌2016

    • Author(s)
      百枝幹雄編集、安部由美子、峯岸敬、他、分担執筆
    • Total Pages
      246
    • Publisher
      診断と治療社
    • Related Report
      2016 Research-status Report 2015 Research-status Report
  • [Remarks] 群馬大学院保健学研究科 医学部保健学科 教員一覧 安部由美子

    • URL

      http://www.health.gunma-u.ac.jp/unit/313.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 群馬大学院医学系研究科 医学部医学科 産科婦人科学

    • URL

      http://www.med.gunma-u.ac.jp/med-organization/bioreg/bioreg-metabolism/119.html

    • Related Report
      2017 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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