The mechanism of change for endometrium at implantation stage

• Project/Area Number: 15K10660
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: The University of Tokyo
• Principal Investigator: SAITO-FUJITA Tomoko 東京大学, 医学部附属病院, 特任研究員 (60375441)
• Co-Investigator(Kenkyū-buntansha): 廣田 泰 東京大学, 医学部附属病院, その他 (40598653)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 子宮内膜 / 着床 / 胚受容能 / プロゲステロンシグナル / 子宮頸部 / マーカー / 遺伝子発現プロファイル / 着床不全 / 次世代シークエンス / 子宮頸部細胞 / 着床不全モデル / 子宮 / 内膜上皮

Outline of Final Research Achievements

Before the embryo implants into the endometrium, the dynamic changes are occurred in the uterus, which is the proliferation-differentiation switching in the luminal epithelium and stromal cells, and is that the serrated structure of uterine lumen becomes to the slit shape. These changes may be associated with Progesterone signaling, but it is undetermined the detail. Thus, we try to analyse the RNA-seq using the luminal and cervix epithelium from the pre-implantation stage between WT and implantation failure model mice for understanding of the mechanism of receptivity association with these dynamic uterus changes at the point of progesterone signaling.
In the results, the expression of 300 genes changed between control and implantation failure mice, and the expression of LIF gene may be as the receptive marker in the cervix epithelium, which are easy to collect than endometrium.

Research Products

• [Journal Article] F4/80+ macrophages contribute to clearance of senescent cells in the mouse postpartum uterus. (2017)
  • Author(s): Egashira M, Hirota Y, Shimizu-Hirota R, Saito-Fujita T, Haraguchi H, Matsumoto L, Matsuo M, Hiraoka T, Tanaka T, Akaeda S, Takehisa C, Saito-Kanatani M, Maeda K, Fujii T, Osuga Y.
  • Journal Title: Endocrinology Volume: 印刷中 Issue: 7 Pages: 2344-2353
  • DOI: 10.1210/en.2016-1886
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 若手の最新研究紹介コーナー「分娩とその異常におけるプロゲステロン受容体の機能解析」 (2017)
  • Author(s): 藤田 知子
  • Journal Title: 産科と婦人科 Volume: 1(75) Pages: 75-77
• [Journal Article] A Potential Role for Endoplasmic Reticulum Stress in Progesterone Deficiency in Obese Women. (2017)
  • Author(s): Takahashi N, Harada M, Hirota Y, Zhao L, Azhary JM, Yoshino O, Izumi G, Hirata T, Koga K, Wada-Hiraike O, Fujii T, Osuga Y.
  • Journal Title: Endocrinology Volume: 158 Pages: 84-97
  • DOI: 10.1210/en.2016-1511
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Drospirenone reduces inflammatory cytokines, vascular endothelial growth factor (VEGF) and nerve growth factor (NGF) expression in human endometriotic stromal cells. (2017)
  • Author(s): Makabe T, Koga K, Miyashita M, Takeuchi A, Sue F, Taguchi A, Urata Y, Izumi G, Takamura M, Harada M, Hirata T, Hirota Y, Wada-Hiraike O, Fujii T, Osuga Y.
  • Journal Title: J Reprod Immunol Volume: 119 Pages: 44-48
  • DOI: 10.1016/j.jri.2016.12.002
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] プロゲスチンとステロイド受容体 (2017)
  • Author(s): 田中智基, 廣田泰
  • Journal Title: Progestin Insights Volume: 1 Pages: 6-7
• [Journal Article] STAT3 accelerates uterine epithelial regeneration in a mouse model of decellularized uterine matrix transplantation. (2016)
  • Author(s): Hiraoka T, Hirota Y, Saito-Fujita T, Matsuo M, Egashira M, Matsumoto L, Haraguchi H, Dey SK, Furukawa KS, Fujii T, Osuga Y.
  • Journal Title: JCI Insight Volume: 1 Issue: 8
  • DOI: 10.1172/jci.insight.87591
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] A potential role of endoplasmic reticulum stress in development of ovarian hyperstimulation syndrome. (2016)
  • Author(s): Takahashi N, Harada M, Hirota Y, Zhao L, Yoshino O, Urata Y, Izumi G, Takamura M, Hirata T, Koga K, Wada-Hiraike O, Fujii T, Osuga Y.
  • Journal Title: Mol Cell Endocrinol Volume: 428 Pages: 161-169
  • DOI: 10.1016/j.mce.2016.03.032
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effects of 1,25-dihydroxy vitamin D3 on endometriosis. (2016)
  • Author(s): Miyashita M, Koga K, Izumi G, Sue F, Makabe T, Taguchi A, Nagai M, Urata Y, Takamura M, Harada M, Hirata T, Hirota Y, Wada-Hiraike O, Fujii T, Osuga Y.
  • Journal Title: J Clin Endocrinol Metab Volume: 101 Issue: 6 Pages: 2371-2379
  • DOI: 10.1210/jc.2016-1515
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Reduced homeobox protein MSX1 in human endometrial tissue is linked to infertility. (2016)
  • Author(s): Bolnick AD, Bolnick JM, Kilburn BA, Stewart T, Oakes J, Rodriguez-Kovacs J, Kohan-Ghadr HR, Dai J, Diamond MP, Hirota Y, Drewlo S, Dey SK, Armant DR; NICHD National Cooperative Reproductive Medicine Network.
  • Journal Title: Hum Reprod Volume: 31 Issue: 9 Pages: 2042-50
  • DOI: 10.1093/humrep/dew143
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Neutrophil depletion reduces endometriotic lesion formation in mice. (2016)
  • Author(s): Takamura M, Koga K, Izumi G, Urata Y, Nagai M, Hasegawa A, Harada M, Hirata T, Hirota Y, Wada-Hiraike O, Fujii T, Osuga Y.
  • Journal Title: Am J Reprod Immunol Volume: 76 Issue: 3 Pages: 193-198
  • DOI: 10.1111/aji.12540
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] p53 coordinates decidual sestrin 2/AMPK/mTORC1 signaling to govern parturition timing. (2016)
  • Author(s): Deng W, Cha J, Yuan J, Haraguchi H, Bartos A, Leishman E, Viollet B, Bradshaw HB, Hirota Y, Dey SK.
  • Journal Title: J Clin Invest Volume: 126 Issue: 8 Pages: 2941-2954
  • DOI: 10.1172/jci87715
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mannose receptor is highly expressed by peritoneal dendritic cells in endometriosis. (2016)
  • Author(s): Izumi G, Koga K, Takamura M, Makabe T, Nagai M, Urata Y, Harada M, Hirata T, Hirota Y, Fujii T, Osuga Y.
  • Journal Title: Fertil Steril Volume: 107 Issue: 1 Pages: 167-173
  • DOI: 10.1016/j.fertnstert.2016.09.036
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dienogest reduces proliferation, NGF expression and nerve fiber density in human adenomyosis. (2016)
  • Author(s): Takeuchi A, Koga K, Miyashita M, Makabe T, Sue F, Harada M, Hirata T, Hirota Y, Fujii T, Osuga Y.
  • Journal Title: Eur J Obstet Gynecol Reprod Biol Volume: 207 Pages: 157-161
  • DOI: 10.1016/j.ejogrb.2016.10.053
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Resveratrol Enhances Apoptosis in Endometriotic Stromal Cells. (2016)
  • Author(s): Taguchi, A., Koga, K., Kawana, K., Makabe, T., Sue, F., Miyashita, M., Yoshida, M., Urata, Y., Izumi, G., Takamura, M., Harada, M., Hirata, T., Hirota, Y., Wada-Hiraike, O., Fujii, T., Osuga, Y
  • Journal Title: American Journal of Reproductive Immunology Volume: 75 Issue: 4 Pages: 486-492
  • DOI: 10.1111/aji.12489
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] How does Progesterone Support Embryo Implantation? (2015)
  • Author(s): Hiraoka, T., Saito-Fujita, T., Hirota, Y.
  • Journal Title: Journal of Mammalian Ova Research Volume: 32 Pages: 87-95
• [Journal Article] 子宮内膜における着床制御因子 プロゲステロン・シグナルを中心に (2015)
  • Author(s): 藤田知子, 廣田泰
  • Journal Title: HORMONE FRONTIER IN GYNECOLOGY Volume: 22 Pages: 176-179
• [Journal Article] Muscle Segment Homeobox Genes Direct Embryonic Diapause by Limiting Inflammation in the Uterus. (2015)
  • Author(s): Cha, J., Burnum-Johnson, K.E., Bartos, A., Li, Y., Baker, ES., Tilton, S.C., Webb-Robertson, B.J., Piehowski, P.D., Monroe, M.E., Jegga, A.G., Murata, S., Hirota, Y., Dey, S.K.
  • Journal Title: The Journal of Biological Chemistry Volume: 290 Issue: 24 Pages: 15337-15349
  • DOI: 10.1074/jbc.m115.655001
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cyclic Stretch Augments Production of Neutrophil Chemokines, Matrix Metalloproteinases, and Activin A in Human Endometrial Stromal Cells. (2015)
  • Author(s): Izumi G, Koga K, Takamura M, Osuga Y.
  • Journal Title: Am J Reprod Immunol Volume: epub Issue: 6 Pages: 501-506
  • DOI: 10.1111/aji.12359
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Drospirenone induces decidualization in human eutopic endometrial stromal cells and reduces DNA synthesis of human endometriotic stromal cells. (2015)
  • Author(s): Miyashita, M., Koga, K., Izumi, G., Makabe, T., Hasegawa, A., Hirota, Y., Hirata, T., Harada, M., Fujii, T., Osuga, Y
  • Journal Title: Fertility and Sterility Volume: 104 Issue: 1 Pages: 217-24
  • DOI: 10.1016/j.fertnstert.2015.03.023
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Evidence of the activation of unfolded protein response in granulosa and cumulus cells during follicular growth and maturation. (2015)
  • Author(s): Harada, M., Nose, E., Takahashi, N., Hirota, Y., Hirata, T., Yoshino, O., Koga, K., Fujii, T., Osuga, Y
  • Journal Title: Gynecological Endocrinology Volume: 31 Issue: 10 Pages: 783-787
  • DOI: 10.3109/09513590.2015.1062862
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Simultaneous Detection and Evaluation of Four Subsets of CD4+ T Lymphocyte in Lesions and Peripheral Blood in Endometriosis. (2015)
  • Author(s): Takamura, M., Koga, K., Izumi, G., Hirata, T., Harada, M., Hirota, Y., Hiraike, O., Fujii, T., Osuga, Y
  • Journal Title: American Journal of Reproductive Immunology Volume: 74 Issue: 6 Pages: 480-486
  • DOI: 10.1111/aji.12426
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Levonorgestrel Inhibits Embryo Implantation by Downregulation of Uterine LIF Expression (2018)
  • Author(s): Mitsunori Matsuo, Yasushi Hirota, Tomoko Saito-Fujita, Hirofumi Haraguchi, Shota Igaue, Leona Matsumoto, Takehiro Hiraoka, Shun Akaeda, Tomoki Tanaka, Tomoyuki Fujii, Yutaka Osuga.
  • Organizer: Society for Reproductive Investigation, 65th Annual Scientific Meeting
  • Int'l Joint Research
• [Presentation] 脱細胞化組織移植技術を用いたマウス子宮再生過程における転写因子STAT3の機能的意義 (2017)
  • Author(s): 平岡毅大, 廣田泰, 藤田知子, 赤枝俊, 田中智基, 松尾光徳, 江頭真宏, 松本玲央奈, 原口広史, 古川克子, 大須賀穣, 藤井知行
  • Organizer: 第16回日本再生医療学会総会
  • Place of Presentation: 宮城
  • Year and Date: 2017-03-07
• [Presentation] Role of STAT3 in the uterine regeneration in a mouse model of decellularized matrix transplantation (2017)
  • Author(s): Takehiro HiraokaYasushi HirotaYutaka Osuga
  • Organizer: Advanced Genome Science International Symposium: The Start of New Genomics
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2017-01-10
  • Int'l Joint Research
• [Presentation] 低酸素誘導因子HIF2αによる子宮内膜への胚浸潤の調節 (2017)
  • Author(s): 松本玲央奈、廣田泰、藤田知子、伊賀上翔太、田中智基、平岡毅大、松尾光徳、原口広史、江頭真宏、赤枝俊、武田憲彦、大須賀穣、藤井知行
  • Organizer: 第62回日本生殖医学会学術講演会
• [Presentation] 卵巣のMouse double minute 2 homolog（Mdm2）欠損による過剰なp53はsteroidogenic factor 1（SF1）を誘導し排卵障害を引き起こす (2017)
  • Author(s): 原口広史，廣田泰，藤田知子，松本玲央奈，松尾光徳，平岡毅大，赤枝俊，田中智基，大須賀穣，藤井知行
  • Organizer: 第62回日本生殖医学会学術講演会
• [Presentation] 白血球阻止因子(LIF)による胚の着床誘導機序についての検討 (2017)
  • Author(s): 平岡毅大、廣田泰、藤田知子、田中智基、赤枝俊、伊賀上翔太、大須賀穣、藤井知行
  • Organizer: 第40回日本分子生物学会
• [Presentation] 子宮のHIF2αは胚盤胞の生存と子宮への浸潤を制御する (2017)
  • Author(s): 藤田知子、廣田泰、松本玲央奈、武田憲彦、藤田英俊、原口広史、松尾光徳、平岡毅大、田中智基 赤枝俊、大須賀穣、藤井知行
  • Organizer: 第40回日本分子生物学会
• [Presentation] Activated IL6-STAT3 pathway in adenomyosis (2017)
  • Author(s): Yasushi Hirota, Takehiro Hiraoka, Tomoko Saito-Fujita, Tomoyuki Fujii, Yutaka Osuga
  • Organizer: World Congress of Endometriosis 2017
• [Presentation] Uterine hypoxia inducible factor contributes to blastocyst invasion by clearance of luminal epithelium at the site of blastocyst attachment (2017)
  • Author(s): Yasushi Hirota, Tomoko Saito-Fujita, Leona Matsumoto, Hirofumi Haraguchi, Mitsunori Matsuo, Takehiro Hiraoka, Shun Akaeda, Tomoki Tanaka, Norihiko Takeda, Yutaka Osuga, Tomoyuki Fujii
  • Organizer: Society for the Study of Reproduction, 50th Annual Meeting
  • Int'l Joint Research
• [Presentation] 黄体ホルモン製剤によるLIF抑制を介した着床阻害作用 (2017)
  • Author(s): 松尾光徳, 廣田泰, 藤田知子, 原口広史, 松本玲央奈, 平岡毅大, 赤枝俊, 田中智基, 大須賀穣, 藤井知行
  • Organizer: 第21回日本生殖内分泌学会学術集会
  • Place of Presentation: 大阪
• [Presentation] 脱細胞化組織移植技術を用いたマウス子宮再生機構の検討 (2017)
  • Author(s): 平岡毅大, 廣田泰, 藤田知子, 赤枝俊, 田中智基, 松尾光徳, 江頭真宏, 松本玲央奈, 原口広史, 古川克子, 大須賀穣, 藤井知行
  • Organizer: 第21回日本生殖内分泌学会学術集会
  • Place of Presentation: 大阪
• [Presentation] 子宮の線維化：子宮腺筋症～IL6／STAT3経路の関与～ (2017)
  • Author(s): 廣田泰
  • Organizer: 第1回Frontier in basic and clinical research of fibrosis
  • Place of Presentation: 愛知
  • Invited
• [Presentation] Role of STAT3 in the endometrial regeneration in a mouse model of decellularized matrix transplantation. (2016)
  • Author(s): 平岡毅大, 廣田泰, 藤田知子, 赤枝俊, 田中智基, 松尾光徳, 江頭真宏, 松本玲央奈, 原口広史, 古川克子, 大須賀穣, 藤井知行
  • Organizer: 第39回日本分子生物学会
  • Place of Presentation: 神奈川
  • Year and Date: 2016-11-30
• [Presentation] 着床胚が接着する場の子宮内膜管腔上皮における遺伝子発現プロファイル (2016)
  • Author(s): 伊賀上翔太, 廣田泰, 藤田知子, 原口広史, 松本玲於奈, 松尾光徳, 平岡毅大, 赤枝俊, 田中智基, 大須賀穣, 藤井知行
  • Organizer: 第39回日本分子生物学会
  • Place of Presentation: 神奈川
  • Year and Date: 2016-11-30
• [Presentation] 低酸素誘導因子HIFが着床を調節する (2016)
  • Author(s): 松本玲央奈, 廣田泰, 藤田知子, 原口広史, 江頭真宏, 松尾光徳, 平岡毅大, 田中智基, 武田憲彦, 大須賀穣, 藤井知行
  • Organizer: 第61回日本生殖医学会学術講演会・総会
  • Place of Presentation: 神奈川
  • Year and Date: 2016-11-03
• [Presentation] 黄体ホルモン製剤レボノルゲストレルによるLIFを介した着床阻害機構 (2016)
  • Author(s): 松尾光徳, 廣田泰, 藤田知子, 原口広史, 江頭真宏, 松本玲央奈, 平岡毅大, 赤枝俊, 田中智基, 藤田英俊, 本道栄一, 大須賀穣, 藤井知行
  • Organizer: 第61回日本生殖医学会学術講演会・総会
  • Place of Presentation: 神奈川
  • Year and Date: 2016-11-03
• [Presentation] 脱細胞化組織移植技術を用いたマウス子宮再生機構の検討 (2016)
  • Author(s): 平岡毅大, 廣田泰, 藤田知子, 赤枝俊, 田中智基, 松尾光徳, 江頭真宏, 松本玲央奈, 原口広史, 古川克子, 大須賀穣, 藤井知行
  • Organizer: 第61回日本生殖医学会学術講演会・総会
  • Place of Presentation: 神奈川
  • Year and Date: 2016-11-03
• [Presentation] 甲状腺刺激ホルモン高値と不妊症との関連についての後方視的検討～第２報～ (2016)
  • Author(s): 平岡毅大, 平池修, 原田美由紀, 平田哲也, 廣田泰, 甲賀かをり, 藤井知行, 大須賀穣
  • Organizer: 第61回日本生殖医学会学術講演会
  • Place of Presentation: 神奈川
  • Year and Date: 2016-11-03
• [Presentation] IL6-STAT3 signaling in adenomyosis (2016)
  • Author(s): Yasushi Hirota
  • Organizer: Asian Conference of Endometriosis 2016
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2016-09-22
  • Int'l Joint Research
• [Presentation] レボノルゲストレルはLIF低下を介して着床を阻害する －プロゲスチンによる避妊作用の新たな機序－ (2016)
  • Author(s): 松尾光徳, 廣田泰, 藤田知子, 原口広史, 江頭真宏, 松本玲央奈, 平岡毅大, 赤枝俊, 田中智基, 藤田英俊, 本道栄一, 大須賀穣, 藤井知行
  • Organizer: 第34回日本受精着床学会総会・学術講演会
  • Place of Presentation: 長野
  • Year and Date: 2016-09-15
• [Presentation] 腹腔鏡下子宮内膜症性卵巣嚢胞摘出術後の嚢胞再発における、腹腔鏡下子宮全摘術の同時施行が与える効果 (2016)
  • Author(s): 原口広史, 廣田泰, 田中智基, 赤枝俊, 平岡毅大, 松尾光徳, 松本玲央奈, 原田美由紀, 平田哲也, 甲賀かをり, 平池修. 大須賀穣, 藤井知行
  • Organizer: 第56回日本産科婦人科内視鏡学会学術講演会
  • Place of Presentation: 長崎
  • Year and Date: 2016-09-01
• [Presentation] STAT3 promotes uterine regeneration in a mouse modelof decellularized uterine matrix transplantation (2016)
  • Author(s): Yasushi Hirota
  • Organizer: Gordon Research Conference on Mammalian Reproduction
  • Place of Presentation: Waterville Valley NH, United States
  • Year and Date: 2016-08-21
  • Int'l Joint Research
• [Presentation] Role of STAT3 in endometrial epithelial regeneration in the mouse model of decellularized matrix transplantation. (2016)
  • Author(s): Takehiro Hiraoka,Yasushi Hirota, Tomoko Saito-Fujita,Furukawa Katsuko Sakai, Tomoyuki Fujii,Yutaka Osuga
  • Organizer: ESHRE2016
  • Place of Presentation: Helsinki, Finland
  • Year and Date: 2016-07-03
  • Int'l Joint Research
• [Presentation] Progesterone responsiveness is not downregulated in adenomyosis. (2016)
  • Author(s): Takehiro Hiraoka, Yasushi Hirota, Tomoko Saito-Fujita, Hirofumi Haraguchi, Miyuki Harada, Tetsuya Hirata, Kaori Koga, Osamu Hiraike, Tomoyuki Fujii, Yutaka Osuga
  • Organizer: SEUD Congress 2016
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2016-05-12
  • Int'l Joint Research
• [Presentation] The process of endometrial reconstruction in the mouse model of decellularized matrix transplantation (2016)
  • Author(s): 平岡毅大, 廣田泰, 藤田知子, 田中智基, 松尾光徳, 原口広史, 松本玲央奈, 大須賀穣藤井知行
  • Organizer: 第68回日本産科婦人科学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2016-04-21
• [Presentation] Leukemia inhibitory factor in the cervical epithelium is a possible biomarker of uterine receptivity. (2016)
  • Author(s): 伊賀上翔太, 廣田泰, 藤田知子, 原口広史, 松本玲央奈, 松尾光徳, 平岡毅大, 田中智基,大須賀穣, 藤井知行
  • Organizer: 第68回日本産科婦人科学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2016-04-21
• [Presentation] Hysterectomy does not change recurrence rate of ovarian endometrioma after cystectomy (2016)
  • Author(s): 原口広史, 廣田泰, 松尾光徳, 平岡毅大, 原田美由紀, 平田哲也, 大須賀穣, 藤井知行
  • Organizer: 第68回日本産科婦人科学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2016-04-21
• [Presentation] 脱細胞化組織移植のマウスモデルを用いた子宮内膜再生機構の解析 (2016)
  • Author(s): 平岡毅大, 廣田泰, 藤田知子, 田中智基, 松尾光徳, 江頭真宏, 原口広史, 松本玲央奈, 古川克子, 大須賀穣, 藤井知行
  • Organizer: 第15回日本再生医療学会総会
  • Place of Presentation: 大阪国際会議場(大阪府大阪市）
  • Year and Date: 2016-03-17
• [Presentation] MicroRNA-200a impairs progesterone signaling in the cervix, disturbing embryo implantation. (2016)
  • Author(s): Hirota, Y., Haraguchi, H., Saito-Fujita, T., Egashira, M., Matsumoto, L., Matsuo, M.,Hiraoka, T., Dey, S.K., Osuga, Y., Fujii, T.
  • Organizer: International Symposium on “Epigenome dynamics and regulation in germ cells”
  • Place of Presentation: 京都大学百周年時計台記念館 (京都府京都市）
  • Year and Date: 2016-02-17
  • Int'l Joint Research
• [Presentation] Endometrial regeneration in the mouse model of decellularized matrix transplantation. (2016)
  • Author(s): Takehiro Hiraoka, Yasushi Hirota
  • Organizer: 平成２７年度「がん研究分野の特性等を踏まえた支援活動」公開シンポジウム
  • Place of Presentation: 一橋講堂 学術総合センター2階(東京都千代田区）
  • Year and Date: 2016-02-08
• [Presentation] プロゲステロンと子宮の機能～着床から分娩まで (2016)
  • Author(s): 廣田泰
  • Organizer: 第5回プロゲスチン研究会
  • Place of Presentation: ホテル椿山荘東京（東京都文京区）
  • Year and Date: 2016-02-06
  • Invited
• [Presentation] 低酸素誘導因子HIF2αによる妊娠成立・維持機構 (2016)
  • Author(s): 松本玲央奈, 廣田泰, 藤田知子, 原口広史, 江頭真宏, 松尾光徳, 平岡毅大, 田中智基, 武田憲彦, 大須賀穣, 藤井知行
  • Organizer: 第20回日本生殖内分泌学会学術集会
  • Place of Presentation: 神戸国際会議場(兵庫県神戸市）
  • Year and Date: 2016-01-09
• [Presentation] 天然型プロゲステロンが着床に与える影響 (2016)
  • Author(s): 廣田泰
  • Organizer: 第3回最適な不妊治療を考える会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 黄体ホルモンによる子宮の胚受容能と着床の調節機構 (2016)
  • Author(s): 廣田泰
  • Organizer: 第5 回プロゲストーゲン研究会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 脱細胞化組織移植のマウスモデルを用いた子宮内膜再生機構の解析 (2015)
  • Author(s): 平岡毅大, 廣田泰, 藤田知子, 田中智基, 松尾光徳, 江頭真宏, 原口広史, 松本玲央奈, 古川克子, 大須賀穣, 藤井知行
  • Organizer: 第38回日本分子生物学会
  • Place of Presentation: 神戸ポートアイランド(兵庫県神戸市）
  • Year and Date: 2015-12-01
• [Presentation] 子宮の低酸素誘導因子HIF2αは妊娠成立に必須である (2015)
  • Author(s): 松本玲央奈, 廣田泰, 藤田知子, 原口広史, 江頭真宏, 松尾光徳, 平岡毅大, 田中智基, 武田憲彦, 大須賀穣, 藤井知行
  • Organizer: 第33回日本受精着床学会総会・学術講演会
  • Place of Presentation: TFTホール(東京都江東区）
  • Year and Date: 2015-11-26
• [Presentation] 着床における低酸素誘導因子HIFの意義 (2015)
  • Author(s): 松本玲央奈, 廣田泰, 藤田知子, 原口広史, 江頭真宏, 松尾光徳, 平岡毅大, 田中智基, 武田憲彦,大須賀穣, 藤井知行
  • Organizer: 第30回日本生殖免疫学会総会
  • Place of Presentation: くまもと県民交流館パレア(熊本県熊本市）
  • Year and Date: 2015-11-21
• [Presentation] 黄体ホルモンが調節する子宮内膜の胚受容能 (2015)
  • Author(s): 廣田泰
  • Organizer: 第6回金沢大学学際科学実験センターシンポジウム
  • Place of Presentation: 金沢大学附属医学図書館 十全記念スタジオ （石川県金沢市）
  • Year and Date: 2015-11-13
  • Invited
• [Presentation] The presence of ovarian hormone-independent endometrial epithelial growth in endometrial remodeling and regeneration (2015)
  • Author(s): Takehiro Hiraoka, Yasushi Hirota.
  • Organizer: The Second International Meeting for Epithelial Tubulology
  • Place of Presentation: 北海道大学医学部学友会館フラテホール（北海道札幌市）
  • Year and Date: 2015-08-22
  • Int'l Joint Research
• [Presentation] Crucial role of hypoxia inducible factor 2alpha in the pregnant uterus (2015)
  • Author(s): Matsumoto, L., Hirota, Y., Saito-Fujita, T., Haraguchi, H., Egashira, M., Matsuo, M., Hiraoka, T., Tanaka, T., Takeda, N., Fujii T., Osuga Y.
  • Organizer: 31th ESHRE Annual Meeting(ESHRE 2015)
  • Place of Presentation: Lisbon（Portugal）
  • Year and Date: 2015-07-14
  • Int'l Joint Research
• [Presentation] Ovarian hormone-independent epithelial growth in uterine remodeling and regeneration. (2015)
  • Author(s): 平岡毅大, 廣田泰, 藤田知子, 原口広史, 松本玲央奈, 江頭真宏, 松尾光徳, 古川克子, 大須賀穣, 藤井知行
  • Organizer: 第15回東京大学生命科学シンポジウム
  • Place of Presentation: 東京大学 武田先端知ビル(東京都文京区）
  • Year and Date: 2015-06-27
• [Presentation] 黄体ホルモンによる妊娠成立・維持のしくみ (2015)
  • Author(s): 廣田泰
  • Organizer: 第38回東京成長ホルモン成長因子セミナー
  • Place of Presentation: 新宿住友ホール（東京都新宿区）
  • Year and Date: 2015-05-22
  • Invited
• [Presentation] The presence of cellular senescence and its possible roles in the postpartum uterus. (2015)
  • Author(s): Egashira, M., Hirota, Y., Saito-Fujita, T., Haraguchi, H., Matsumoto L., Matsuo, M., Hiraoka, T., Osuga, Y., Fujii, T.
  • Organizer: International Federation of Fertility Societies/Japanese Society for Reproductive Medicine International Meeting 2015.
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市）
  • Year and Date: 2015-04-26
  • Int'l Joint Research
• [Presentation] MicroRNA controls receptivity to the embryo by regulating progesterone signaling in the cervix and uterus. (2015)
  • Author(s): Haraguchi, H., Hirota, Y., Saito-Fujita, T., Egashira, M., Matsumoto, L., Matsuo, M., Hiraoka, T., Osuga, Y., Fujii, T.
  • Organizer: International Federation of Fertility Societies/Japanese Society for Reproductive Medicine International Meeting 2015.
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市）
  • Year and Date: 2015-04-26
  • Int'l Joint Research
• [Presentation] 子宮におけるプロゲステロン受容体シグナルと着床 (2015)
  • Author(s): 廣田泰
  • Organizer: 第60回日本生殖医学会学術講演会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市）
  • Year and Date: 2015-04-26
  • Invited
• [Remarks] 【プレスリリース】転写因子STAT3を介した子宮内膜の再構築と子宮の再生の仕組み
  • URL: http://www.h.u-tokyo.ac.jp/vcms_lf/release_20160603-1.pdf