| Project/Area Number |
15K10662
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | University of Toyama |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
齋藤 滋 富山大学, 大学院医学薬学研究部(医学), 教授 (30175351)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 切迫早産 / 抗菌薬 / 羊水中微生物 / ウレアプラズマ / 子宮内炎症 / スラッジ / 羊水中病原微生物 |
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| Outline of Final Research Achievements |
Antibiotic therapy for preterm labor cases are effective for maternal infection, but it is rather worse for neonatal prognosis. However, intra-amniotic microbes are not evaluated.
A rapid and sensitive PCR system developped in our hospital could evaluate intra-amniotic microbes accurately. By using this PCR system, in positive-cases with intra-amniotic microbes, an appropriate antibiotic therapy could prolong the gestational days, whereas in negative-cases, an antibiotic had shortened the gestational period.
The intra-amniotic microbes should be detected accurately and an appropriate antibiotic therapy might be able to be a new strategy in management of preterm labor.
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