Could an appropriate antibiotic therapy improve neonatal outcome in preterm labor cases?
| Project/Area Number |
15K10662
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | University of Toyama |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
齋藤 滋 富山大学, 大学院医学薬学研究部(医学), 教授 (30175351)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 切迫早産 / 抗菌薬 / 羊水中微生物 / ウレアプラズマ / 子宮内炎症 / スラッジ / 羊水中病原微生物 |
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| Outline of Final Research Achievements |
Antibiotic therapy for preterm labor cases are effective for maternal infection, but it is rather worse for neonatal prognosis. However, intra-amniotic microbes are not evaluated.
A rapid and sensitive PCR system developped in our hospital could evaluate intra-amniotic microbes accurately. By using this PCR system, in positive-cases with intra-amniotic microbes, an appropriate antibiotic therapy could prolong the gestational days, whereas in negative-cases, an antibiotic had shortened the gestational period.
The intra-amniotic microbes should be detected accurately and an appropriate antibiotic therapy might be able to be a new strategy in management of preterm labor.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Sludge reflects intra-amniotic inflammation with or without microorganisms.2018
Author(s)
Yoneda N, Yoneda S, Niimi H, Ito M, Fukuta K, Ueno T, Ito M, Shiozaki A, Kigawa M, Kitajima I, Saito S.
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Journal Title
Am J Reprod Immunol.
Volume: 79(2)
Issue: 2
Pages: 1-8
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A yolk sac larger than 5 mm suggests an abnormal fetal karyotype, whereas an absent embryo indicates a normal fetal karyotype.2018
Author(s)
Yoneda S, Shiozaki A, Yoneda N, Sameshima A, Ito M, Shima T, Nakashima A, Yoshino O, Kigawa M, Takamori R, Shinagawa Y and Saito S
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Journal Title
J Ultrasound Med
Volume: 37
Issue: 5
Pages: 1233-1241
DOI
Related Report
Peer Reviewed
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[Journal Article] Antibiotic Therapy Increases the Risk of Preterm Birth in Preterm Labor without Intra-Amniotic Microbes, but may Prolong the Gestation Period in Preterm Labor with Microbes, Evaluated by Rapid and High-Sensitive PCR System2016
Author(s)
Yoneda S, Shiozaki A, Yoneda N, Ito M, Shima T, Fukuda K, Ueno T, Niimi H, Kitajima I, Kigawa M, Saito S
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Journal Title
American Journal of Reproductive Immunology
Volume: 75(4)
Issue: 4
Pages: 440-50
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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