| Project/Area Number |
15K10665
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Shinshu University |
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Principal Investigator |
Ohira Satoshi 信州大学, 学術研究院医学系(医学部附属病院), 講師 (90397315)
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| Co-Investigator(Kenkyū-buntansha) |
塩沢 丹里 信州大学, 学術研究院医学系, 教授 (20235493)
樋口 正太郎 信州大学, 医学部附属病院, 助教(診療) (50750098)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | Neuregulin-1β1 / maternal blood / umbilical venous blood / hypertensive disorders / fetal lung maturation / Neuregulin-1 / 胎児肺成熟 / 胎盤絨毛内血管内皮細胞 / 母体血 / 妊娠高血圧症候群 |
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| Outline of Final Research Achievements |
Aim: To evaluate the predictive power of NRG-1 for fetal lung maturation. Methods: Fifty two blood samples (21: with hypertensive disorders of pregnancy (HDP), 31: control) of the umbilical vein at delivery and 28 samples of the maternal blood (18: with HDP, 10: control) before delivery were collected. The plasma levels of NRG-1β1 in these samples were measured using ELISA assay. Results: The median plasma NRG-1β1 levels in the umbilical vein in HDP patients was 1.97 ng/mL, and was significantly higher than that of control (1.21 ng/mL, p < 0.05). The median plasma NRG-1β1 levels in the maternal blood in HDP patients was 5.21 ng/mL, and was significantly higher than that of control patients (0.27 ng/mL, p < 0.05). Conclusion: The elevated plasma NRG-1β1 levels in the umbilical venous blood in patients with HDP may stimulate fetal lung maturation. The concentration of NRG-1β1 in the maternal blood may be useful for predicting the fetal lung maturation in women with HDP.
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