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In utero Immune tolerance induction for Severe Congenital skin diseases

Research Project

Project/Area Number 15K10669
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionOsaka University

Principal Investigator

ENDO MASAYUKI  大阪大学, 医学系研究科, 講師 (30644794)

Co-Investigator(Kenkyū-buntansha) 玉井 克人  大阪大学, 医学系研究科, 寄附講座教授 (20236730)
冨松 拓治  大阪大学, 医学(系)研究科(研究院), 講師 (30346209)
味村 和哉  大阪大学, 医学(系)研究科(研究院), 助教 (50437422)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords胎児治療 / 免疫寛容 / 幹細胞 / 移植 / マイクロキメリズム / 産科学 / 間葉系幹細胞 / 母体胎児間マイクロキメリズム / 絨毛採取 / 超音波 / 幹細胞移植 / 血液幹細胞
Outline of Final Research Achievements

Induction of immunological reactions is a major problem in replacement therapies for inherited protein deficiencies. Tolerance created in utero can facilitate postnatal treatment. In this study, we show that cell transplantation into the chorionic villi under ultrasound guidance in the earliest gestation can induce immune tolerance towards a foreign protein within rodent models.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (34 results)

All 2017 2016 2015

All Journal Article (20 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 20 results,  Open Access: 15 results,  Acknowledgement Compliant: 3 results) Presentation (12 results) (of which Int'l Joint Research: 6 results,  Invited: 3 results) Book (2 results)

  • [Journal Article] Treatment and repair of uterine scar dehiscence during cesarean section2017

    • Author(s)
      Sawada, M. Matsuzaki, S. Nakae, R. Iwamiya, T. Kakigano, A. Kumasawa, K. Ueda, Y. Endo, M. Kimura, T.
    • Journal Title

      Clin Case Rep

      Volume: 5 Issue: 2 Pages: 145-149

    • DOI

      10.1002/ccr3.766

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Successful anticoagulant therapy for disseminated intravascular coagulation during conservative management of placenta percreta: a case report and literature review2017

    • Author(s)
      Matsuzaki, S. Yoshino, K. Endo, M. Tomimatsu, T. Takiuchi, T. Mimura, K. Kumasawa, K. Ueda, Y. Kimura, T.
    • Journal Title

      BMC Pregnancy Childbirth

      Volume: 17 Issue: 1 Pages: 443-443

    • DOI

      10.1186/s12884-017-1634-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vasa previa with an intact amniotic membrane2017

    • Author(s)
      Matsuzaki, S. Endo, M. Kimura, T.
    • Journal Title

      Am J Obstet Gynecol.

      Volume: 216 Issue: 6 Pages: 616.e1-616.e2

    • DOI

      10.1016/j.ajog.2017.03.003

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Investigation of perioperative complications associated with uterine compression sutures2017

    • Author(s)
      Suzuki, Y. Matsuzaki, S. Mimura, K. Kumasawa, K. Tomimatsu, T. Endo, M. Kimura, T.
    • Journal Title

      Int J Gynaecol Obstet

      Volume: 139 Issue: 1 Pages: 28-33

    • DOI

      10.1002/ijgo.12249

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pregnancy outcomes in women with different doses of corticosteroid supplementation during labor and delivery2017

    • Author(s)
      Owa, T. Mimura, K. Kakigano, A. Matsuzaki, S. Kumasawa, K. Endo, M. Tomimatsu, T. Kimura, T.
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 43 Issue: 7 Pages: 1132-1138

    • DOI

      10.1111/jog.13336

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case of acute sheehan’s syndrome and literature review: a rare but life-threatening complication of postpartum hemorrhage2017

    • Author(s)
      Matsuzaki, S. Endo, M. Ueda, Y. Mimura, K. Kakigano, A. Egawa-Takata, T. Kumasawa, K. Yoshino, K. Kimura, T.
    • Journal Title

      BMC Pregnancy Childbirth

      Volume: 17 Issue: 1 Pages: 188-188

    • DOI

      10.1186/s12884-017-1380-y

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 胎児遺伝子治療2017

    • Author(s)
      遠藤 誠之
    • Journal Title

      周産期医学

      Volume: 47 Pages: 571-576

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 胎児期幹細胞移植の現状と将来2017

    • Author(s)
      遠藤 誠之
    • Journal Title

      医学のあゆみ

      Volume: 261 Pages: 1229-1234

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Physician-initiated first-in-human clinical study using a novel angiogenic peptide, AG30/5C, for patients with severe limb ulcers2017

    • Author(s)
      Nakagami Hironori、Yamaoka Toshifumi、Hayashi Misa、Tanemura Atsushi、Takeya Yasushi、Kurinami Hitomi、Sugimoto Ken、Nakamura Ayumi、Tomono Kazunori、Tamai Katsuto、Katayama Ichiro、Rakugi Hiromi、Kaneda Yasufumi
    • Journal Title

      Geriatr Gerontol Int.

      Volume: 17 Issue: 11 Pages: 2150-2156

    • DOI

      10.1111/ggi.13051

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pathophysiology of preeclampsia: an angiogenic imbalance and long-lasting systemic vascular dysfunction.2016

    • Author(s)
      Tomimatsu T, Mimura K, Endo M, Kumasawa K, Kimura T.
    • Journal Title

      Hypertens Res

      Volume: 40(4) Issue: 4 Pages: 305-310

    • DOI

      10.1038/hr.2016.152

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Expression levels of ABCG2 on cord red blood cells and study of fetal anemia associated with anti-Jr(a).2016

    • Author(s)
      Fujita S, Kashiwagi H, Tomimatsu T, Ito S, Mimura K, Kanagawa T, Endo M, Miyoshi T, Okamura Y, Tani Y, Tomiyama Y, Kimura T.
    • Journal Title

      Transfusion.

      Volume: 56 Issue: 5 Pages: 1171-1181

    • DOI

      10.1111/trf.13515

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cervical varix complicated by placenta previa: A case report and literature review.2016

    • Author(s)
      Tanaka M, Matsuzaki S, Kumasawa K, Suzuki Y, Endo M, Kimura T.
    • Journal Title

      J Obstet Gynaecol Res.

      Volume: 42 Issue: 7 Pages: 883-889

    • DOI

      10.1111/jog.12969

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Placenta accreta following hysteroscopic myomectomy.2016

    • Author(s)
      Tanaka M, Matsuzaki S, Matsuzaki S, Kakigano A, Kumasawa K, Ueda Y, Endo M, Kimura T.
    • Journal Title

      Clin Case Rep

      Volume: 4(6) Issue: 6 Pages: 541-544

    • DOI

      10.1002/ccr3.562

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Successful conservative management of placenta percreta: Investigation by serial magnetic resonance imaging of the clinical course and a literature review.2016

    • Author(s)
      Sawada M, Matsuzaki S, Mimura K, Kumasawa K, Endo M, Kimura T.
    • Journal Title

      J Obstet Gynaecol Res.

      Volume: 42 Issue: 12 Pages: 1858-1863

    • DOI

      10.1111/jog.13121

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pulmonary transcriptome analysis in the surgically induced rabbit model of diaphragmatic hernia treated with fetal tracheal occlusion2016

    • Author(s)
      Engels, A. C. Brady, P. D. Kammoun, M. Finalet Ferreiro, J. DeKoninck, P. Endo, M. Toelen, J. Vermeesch, J. R. Deprest, J.
    • Journal Title

      Dis Model Mech.

      Volume: 9 Pages: 221-228

    • DOI

      10.1242/dmm.021626

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Immune tolerance induction using fetal directed placental injection in rodent models: a murine model.2015

    • Author(s)
      Takahashi, K. Endo, M. Miyoshi, T. Tsuritani, M. Shimazu, Y. Hosoda, H. Saga, K. Tamai, K. Flake, AW. Yoshimatsu, J. Kimura, T.
    • Journal Title

      PLoS One.

      Volume: 10(4) Issue: 4 Pages: e0123712-e0123712

    • DOI

      10.1371/journal.pone.0123712

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] High-frequency micro-ultrasound: a novel method to assess external urethral sphincter function in rats following simulated birth injury2015

    • Author(s)
      Hakim, L. Endo, M. Feola, A. Soebadi, D. M. Deprest, J. De Ridder, D. Albersen, M. Van der Aa, F.
    • Journal Title

      Neurourology and Urodynamics

      Volume: 34 Issue: 3 Pages: 264-269

    • DOI

      10.1002/nau.22555

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Thrombocytopenia associated with Mycoplasma pneumonia during pregnancy: Case presentation and approach for differential diagnosis2015

    • Author(s)
      Nishikawa, A. Mimura, K. Kanagawa, T. Maeda, T. Tomimatsu, T. Kimura, T.
    • Journal Title

      Journal of Obstetrics and Gynaecology Research

      Volume: 41 Issue: 8 Pages: 1273-1277

    • DOI

      10.1111/jog.12713

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Pregnancy management for a patient with graft occlusion after right iliac artery bypass surgery2015

    • Author(s)
      Nakae, R. Matsuzaki, S. Egawa-Takata, T. Mimura, K. Kanagawa, T. Kimura, T.
    • Journal Title

      Journal of Obstetrics and Gynaecology Research

      Volume: 41 Issue: 6 Pages: 979-984

    • DOI

      10.1111/jog.12636

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Drug repositioning for preeclampsia therapeutics by in vitro screening: phosphodiesterase-5 inhibitor vardenafil restores endothelial dysfunction via induction of placental growth factor2015

    • Author(s)
      Kakigano, A. Tomimatsu, T. Mimura, K. Kanayama, T. Fujita, S. Minato, K. Kumasawa, K. Taniguchi, Y. Kanagawa, T. Endo, M. Ishihara, T. Namba, T. Mizushima, T. Kimura, T.
    • Journal Title

      Reproductive Sciences

      Volume: 10 Issue: 10 Pages: 1272-80

    • DOI

      10.1177/1933719115574340

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] Intra-Chorionic Villi Injection At Early Gestational Stage Can Induce Immue Tolerance Towards Allogeneic Cells In A Murine Model.2017

    • Author(s)
      Endo M.
    • Organizer
      3rd Meeting of the International Fetal Immunology and Trasplantations Society
    • Place of Presentation
      Philadelphia(U.S.A)
    • Year and Date
      2017-03-23
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Intra-Chorionic Villi Injection at Early Gestational Stage Can Induce Immune Tolerance Towards Allogeneic Cells In A Murine Model.2017

    • Author(s)
      Endo M, Shimazu Y, Okada A.
    • Organizer
      3rd Meeting of the International Fetal Immunology and Transplantations Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A 9-years Experience of Induced trimester abortion is a single tertiary refferal center.2017

    • Author(s)
      Endo M, Mimura K, Tomimatsu T, Matsuzaki S, Kumasawa K, Matsumoto Y, Kinose Y, Iwamiya T, Kimura T.
    • Organizer
      第69回日本産科婦人科学会学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 胎児共存奇胎とその鑑別を要した6症例の検討2017

    • Author(s)
      味村 和哉, 遠藤 誠之, 柿ヶ野 藍子, 木村 正.
    • Organizer
      第53回日本周産期・新生児医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 当院における妊娠中期中絶症例について2017

    • Author(s)
      遠藤 誠之, 松崎 慎也, 熊澤 惠一, 味村 和哉, 瀧内 剛, 木村 正.
    • Organizer
      第53回日本周産期・新生児医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 胎児治療最前線2016

    • Author(s)
      遠藤 誠之
    • Organizer
      日本臨床麻酔学会 第36回大会
    • Place of Presentation
      高知
    • Year and Date
      2016-11-03
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Prenatal Diagnosis of Airway Obstruction Improves Perinatal Outcomes.2016

    • Author(s)
      Endo M
    • Organizer
      12th Asia Pacific Congress in Maternal Fetal Medicine
    • Place of Presentation
      Malaysia(Penang)
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] In utero stem cell and gene therapy2016

    • Author(s)
      Endo M.
    • Organizer
      The 60th Anniversary Celebration Educational Seminar
    • Place of Presentation
      ウランバートル(モンゴル)
    • Year and Date
      2016-09-07
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Immune tolerance induction using fetal directed placental injection in rodent models.2016

    • Author(s)
      Endo M.
    • Organizer
      12th Congress of International Academy of Perinatal Medicine
    • Place of Presentation
      Tirana(Albania)
    • Year and Date
      2016-05-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] In utero stem cell therapy for Osteogenesis Imperfecta : a clinical case report2016

    • Author(s)
      Endo M, Takahashi K, Ito Y, Kanagawa T, Fukui O, Mimura K, Kakigano A, Shimazu Y, Kajimoto E, Tomimatsu T, Kimura T.
    • Organizer
      第68回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2016-04-21
    • Related Report
      2016 Research-status Report
  • [Presentation] Shunting Instruments - which is best2016

    • Author(s)
      Endo M.
    • Organizer
      Asia Pacific Conference on Fetal Therapy 2016
    • Place of Presentation
      Singapore(National University of Singapore)
    • Year and Date
      2016-04-16
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] USG and MRI of pelvic floor during pregnancy and postpartum2015

    • Author(s)
      Endo, M.
    • Organizer
      11th Asia Pacific Congress in Maternal Fetal Medicine
    • Place of Presentation
      Taiwan, China
    • Year and Date
      2015-11-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Book] 新生児先天性横隔膜ヘルニア(CDH)診療ガイドライン2016

    • Author(s)
      遠藤 誠之、臼井 規朗、左合 治彦 他新生児先天性横隔膜ヘルニア研究グループ
    • Total Pages
      114
    • Publisher
      メジカルビュー社
    • Related Report
      2016 Research-status Report
  • [Book] 小児外科2016

    • Author(s)
      遠藤 誠之、和田 誠司、左合 治彦、木村 正 他
    • Total Pages
      120
    • Publisher
      東京医学社
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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