Significance of serum anti-Mullerian hormone and insulin resistance in the diagnosis of polycystic ovary syndrome

• Project/Area Number: 15K10672
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: The University of Tokushima
• Principal Investigator: IRAHARA Minoru 徳島大学, 大学院医歯薬学研究部(医学系), 教授 (20160070)
• Co-Investigator(Kenkyū-buntansha): 松崎 利也 徳島大学, 大学院医歯薬学研究部(医学系), 准教授 (70294692) ; 岩佐 武 徳島大学, 病院, 特任准教授 (00707903)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 多嚢胞性卵巣症候群 / PCOS / 抗ミュラー管ホルモン / AMH / 年齢

Outline of Final Research Achievements

We studied the significance of serum Anti-Mullerian hormone and insulin resistance (IR) in the diagnosis of polycystic ovary syndrome (PCOS). Serum AMH level was higher in PCOS than in normal cyclic women. Correlations between serum AMH level and various endocrine and metabolic factors (26 factors) were analysed in PCOS and 12 factors showed significant correlations with AMH although IR did not show significant correlation. Only ovarian volume showed the strongest positive correlation (r=0.62) with the serum AMH level on multiple regression analysis. A cut-off value of 10 ng/mL had a high specificity of 92.6%, although the sensitivity was low (24.6%). The serum AMH level could be a surrogate for ultrasound findings of the ovaries in the diagnosis of PCOS.

Research Products

• [Journal Article] Effects of dihydrotestosterone administration on the expression of reproductive and body weight regulatory factors in ovariectomized and estradiol-treated female rats (2018)
  • Author(s): Iwasa Takeshi、Matsuzaki Toshiya、Yano Kiyohito、Mayila Yiliyasi、Irahara Minoru
  • Journal Title: Gynecological Endocrinology Volume: 34 Issue: 1 Pages: 73-77
  • DOI: 10.1080/09513590.2017.1337096
  • NAID: 120006535069
  • Peer Reviewed
• [Journal Article] Assisted reproductive technology in Japan: a summary report of 1992-2014 by the Ethics Committee, Japan Society of Obstetrics and Gynecology (2017)
  • Author(s): Irahara Minoru、Kuwahara Akira、Iwasa Takeshi、Ishikawa Tomonori、Ishihara Osamu、Kugu Koji、Sawa Rintaro、Banno Kouji、Saito Hidekazu
  • Journal Title: Reprod Med Biol. Volume: 16 Issue: 2 Pages: 126-132
  • DOI: 10.1002/rmb2.12014
  • NAID: 120006550818
  • Peer Reviewed
• [Journal Article] Pregnancy and neonatal outcomes following letrozole use in frozen-thawed single embryo transfer cycles. (2017)
  • Author(s): Tatsumi T.、Jwa S.C.、Kuwahara A.、Irahara M.、Kubota T.、Saito H.
  • Journal Title: Human Reproduction Volume: 32 Issue: 6 Pages: 1244-1248
  • DOI: 10.1093/humrep/dex066
  • Peer Reviewed
• [Journal Article] Age-specific serum anti-Müllerian hormone concentration in Japanese women and its usefulness as a predictor of the ovarian response. (2017)
  • Author(s): Asada Y, Morimoto Y, Nakaoka Y, Yamasaki T, Suehiro Y, Sugimoto H, Yoshida M, Irahara M.
  • Journal Title: Reprod Med Biol. Volume: 16(4) Issue: 4 Pages: 364-373
  • DOI: 10.1002/rmb2.12055
  • NAID: 120006550823
  • Peer Reviewed / Open Access
• [Journal Article] Relationship between serum anti-Mullerian hormone and clinical parameters in polycystic ovary syndrome (2017)
  • Author(s): Matsuzaki Toshiya、Munkhzaya Munkhsaikhan、Iwasa Takeshi、Tungalagsuvd Altankhuu、Yano Kiyohito、Mayila Yiliyasi、Yanagihara Rie、Tokui Takako、Kato Takeshi、Kuwahara Akira、Matsui Sumika、Irahara Minoru
  • Journal Title: Endocrine Journal Volume: 64 Issue: 5 Pages: 531-541
  • DOI: 10.1507/endocrj.EJ16-0501
  • NAID: 130005682842
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed
• [Journal Article] The effects of chronic testosterone administration on body weight, food intake, and adipose tissue are changed by estrogen treatment in female rats (2017)
  • Author(s): Iwasa Takeshi、Matsuzaki Toshiya、Yano Kiyohito、Yanagihara Rie、Tungalagsuvd Altankhuu、Munkhzaya Munkhsaikhan、Mayila Yiliyasi、Kuwahara Akira、Irahara Minoru
  • Journal Title: Hormones and Behavior Volume: 93 Pages: 53-61
  • DOI: 10.1016/j.yhbeh.2017.05.008
  • NAID: 120006535070
  • Peer Reviewed
• [Journal Article] The effects of chronic testosterone administration on body weight, food intake, and fat weight were age-dependent (2017)
  • Author(s): Iwasa Takeshi、Matsuzaki Toshiya、Yiliyasi Mayila、Yano Kiyohito、Irahara Minoru
  • Journal Title: Steroids Volume: 127 Pages: 18-23
  • DOI: 10.1016/j.steroids.2017.08.014
  • NAID: 120006535068
  • Peer Reviewed
• [Journal Article] Clinical outcome of various metformin treatments for women with polycystic ovary syndrome (2017)
  • Author(s): Matsuzaki Toshiya、Tungalagsuvd Altankhuu、Iwasa Takeshi、Munkhzaya Munkhsaikhan、Yano Kiyohito、Mayila Yiliyasi、Tokui Takako、Yanagihara Rie、Matsui Sumika、Kato Takeshi、Kuwahara Akira、Irahara Minoru
  • Journal Title: Reprod Med Biol. Volume: 16 Issue: 2 Pages: 179-187
  • DOI: 10.1002/rmb2.12026
  • NAID: 120006550820
  • Peer Reviewed
• [Journal Article] Weight reduction using a formula diet recovers menstruation in obese patients with an ovulatory disorder (2017)
  • Author(s): Matsuzaki Toshiya、Douchi Tsutomu、Oki Toshimichi、Ishihara Osamu、Okagaki Ryugo、Kajihara Takeshi、Tamura Midori、Kotsuji Fumikazu、Tajima Kimihisa、Kawano Mika、Ishizuka Bunpei、Irahara Minoru
  • Journal Title: Reproductive Medicine and Biology Volume: 16 Issue: 3 Pages: 268-275
  • DOI: 10.1002/rmb2.12034
  • NAID: 120006550821
  • Peer Reviewed
• [Journal Article] Prenatal undernutrition disrupted the sexual maturation, but not the sexual behavior, in male rats (2017)
  • Author(s): Matsuzaki Toshiya、Munkhzaya Munkhsaikhan、Tungalagsuvd Altankhuu、Mayila Yiliyasi、Iwasa Takeshi、Yano Kiyohito、Yanagihara Rie、Tokui Takako、Kato Takeshi、Kuwahara Akira、Matsui Sumika、Irahara Minoru
  • Journal Title: Reproductive Medicine and Biology Volume: 16 Issue: 4 Pages: 325-329
  • DOI: 10.1002/rmb2.12045
  • NAID: 120006550822
  • Peer Reviewed
• [Journal Article] 多嚢胞性卵巣症候群テストステロン (2017)
  • Author(s): 矢野清人、松崎利也、苛原 稔
  • Journal Title: 最新女性医療 Volume: 4 Pages: 17-22
• [Journal Article] インスリン抵抗性改善薬～女性不妊における治療薬の基礎と実践：いつ・だれに・どう使うかー⑥～ (2017)
  • Author(s): 松崎利也
  • Journal Title: 薬局 Volume: 68 Pages: 70-74
• [Journal Article] 症例：不妊治療②多嚢胞性卵巣症候群の画像診断とその臨床的意義は？ (2017)
  • Author(s): 岩佐 武、松崎利也、矢野清人、苛原 稔
  • Journal Title: 産婦人科画像診断トレーニング 臨床婦人科産科－2017増刊号－ Volume: 71 Pages: 199-202
• [Journal Article] 高プロラクチン血症と妊娠 (2017)
  • Author(s): 德井貴子、松崎利也、苛原 稔
  • Journal Title: ホルモンと臨床 Volume: 印刷中
• [Journal Article] The advancement of the onset of vaginal opening in female rats subjected to chronic testosterone treatment occurs independently of hypothalamic Kiss1 and RFRP expression. (2016)
  • Author(s): Iwasa T, Matsuzaki T, Tungalagsuvd A, Munkhzaya M, Kuwahara A, Yasui T, Irahara M.
  • Journal Title: Neuro Endocrinol Lett. Volume: 36 Pages: 767-770
  • Peer Reviewed
• [Journal Article] Multiple Androgen Biosynthesis Pathways Are Operating in Women with Polycystic Ovary Syndrome. (2016)
  • Author(s): Saito K, Matsuzaki T, Iwasa T, Miyado M, Saito H, Hasegawa T, Homma K, Inoue E, Kubota T, Irahara M, Ogata T, Fukami M
  • Journal Title: J Steroid Biochem Mol Biol Volume: 158 Pages: 31-37
  • DOI: 10.1016/j.jsbmb.2016.02.010
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Developmental changes in the hypothalamic mRNA levels of nucleobindin-2 (NUCB2) and their sensitivity to fasting in male and female rats. (2016)
  • Author(s): Iwasa T, Matsuzaki T, Tungalagsuvd A, Munkhzaya M, Yiliyasi M, Kuwahara A, Irahara M.
  • Journal Title: Int J Dev Neurosci. Volume: 49 Issue: 1 Pages: 46-49
  • DOI: 10.1016/j.ijdevneu.2016.01.003
  • Peer Reviewed
• [Journal Article] The expression of orexigenic and anorexigenic factors in middle-aged female rats that had been subjected to prenatal undernutrition. (2016)
  • Author(s): Tungalagsuvd A, Matsuzaki T, Iwasa T, Munkhzaya M, Yiliyasi M, Kawami T, Kato T, Kuwahara A, Irahara M.
  • Journal Title: Int J Dev Neurosci. Volume: 49 Issue: 1 Pages: 1-5
  • DOI: 10.1016/j.ijdevneu.2015.12.002
  • Peer Reviewed
• [Journal Article] Blood allopregnanolone levels in women with polycystic ovary syndrome. (2016)
  • Author(s): Saito K, Matsuzaki T, Iwasa T, Miyado M, Saito H, Kubota T, Irahara M, Ogata T, Fukami M*
  • Journal Title: Clin Endocrinol Volume: 未定 Issue: 1 Pages: 151-152
  • DOI: 10.1111/cen.13080
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effects of chronic DHEA treatment on central and peripheral reproductive parameters, the onset of vaginal opening and the estrous cycle in female rats. (2016)
  • Author(s): Iwasa T, Matsuzaki T, Tungalagsuvd A, Munkhzaya M, Yiliyasi M, Kato T, Kuwahara A, Irahara M.
  • Journal Title: Gynecol Endocrinol. Volume: 32 Pages: 752-755
  • Peer Reviewed
• [Journal Article] 電気化学発光免疫測定法（ECLIA法）を用いたプロゲステロン測定キット「エクルーシス試薬プロゲステロンⅢ」の基本性能評価および基準範囲の検討 (2016)
  • Author(s): 松崎利也、岩佐 武、徳井貴子、Yiliyasi Mayila、杉本 光、苛原 稔
  • Journal Title: 医学と薬学 Volume: 73 Pages: 323-333
• [Journal Article] 多嚢胞性卵巣症候群 (2016)
  • Author(s): 松崎利也
  • Journal Title: 産婦人科処方実践マニュアル：産科と婦人科 Volume: 83 Pages: 243-247
  • Peer Reviewed
• [Journal Article] 差分解説：多嚢胞性卵巣症候群(PCOS) 治療の必要性 (2016)
  • Author(s): 松崎利也
  • Journal Title: 日本医事新報 Volume: 4788 Pages: 59-59
  • Peer Reviewed
• [Journal Article] The responses of hypothalamic NPY and OBRb mRNA expression to food deprivation develop during the neonatal-prepubertal period and exhibit gender differences in rats. (2015)
  • Author(s): Matsuzaki T, Iwasa T, Tungalagsuvd A, Munkhzaya M, Kawami T, Yamasaki M, Murakami M, Kato T, Kuwahara A, Yasui T, Irahara M.
  • Journal Title: Int J Dev Neurosci. Volume: 41 Issue: 1 Pages: 63-67
  • DOI: 10.1016/j.ijdevneu.2014.11.006
  • Peer Reviewed / Open Access
• [Journal Article] Developmental changes in hypothalamic oxytocin and oxytocin receptor mRNA expression and their sensitivity to fasting in male and female rats. (2015)
  • Author(s): Matsuzaki T, Iwasa T, Munkhzaya M, Tungalagsuvd A, Kawami T, Murakami M, Yamasaki M, Yamamoto Y, Kato T, Kuwahara A, Yasui T, Irahara M.
  • Journal Title: Int J Dev Neurosci. Volume: 41 Issue: 1 Pages: 105-109
  • DOI: 10.1016/j.ijdevneu.2015.01.001
  • Peer Reviewed / Open Access
• [Journal Article] The effects of prenatal undernutrition and postnatal high-fat diet on hypothalamic Kiss1 mRNA and serum leptin levels. (2015)
  • Author(s): Iwasa T, Matsuzaki T, Munkhzaya M, Tungalagsuvd A, Yamasaki M, Kuwahara A, Yasui T, Irahara M.
  • Journal Title: Int J Dev Neurosci. Volume: 42 Issue: 1 Pages: 76-79
  • DOI: 10.1016/j.ijdevneu.2015.03.001
  • Peer Reviewed / Open Access
• [Journal Article] LH and testosterone production are more sensitive to the suppressive effects of food deprivation in prenatally undernourished male rats. (2015)
  • Author(s): Iwasa T, Matsuzaki T, Tungalagsuvd A, Munkhzaya M, Kuwahara A, Yasui T, Irahara M.
  • Journal Title: Int J Dev Neurosci. Volume: 43 Issue: 1 Pages: 66-69
  • DOI: 10.1016/j.ijdevneu.2015.04.001
  • Peer Reviewed
• [Journal Article] Prenatal undernutrition increases the febrile response to lipopolysaccharides in adulthood in male rats. (2015)
  • Author(s): Iwasa T, Matsuzaki T, Tungalagsuvd A, Munkhzaya M, Kuwahara A, Yasui T, Irahara M.
  • Journal Title: Int J Dev Neurosci. Volume: 44 Issue: 1 Pages: 1-5
  • DOI: 10.1016/j.ijdevneu.2015.04.004
  • Peer Reviewed
• [Journal Article] The suppressive effect of immune stress on LH secretion is absent in the early neonatal period in rats. (2015)
  • Author(s): Munkhzaya M, Matsuzaki T, Iwasa T, Tungalagsuvd A, Kawami T, Kato T, Kuwahara A, Irahara M.
  • Journal Title: Int J Dev Neurosci. Volume: 46 Issue: 1 Pages: 38-43
  • DOI: 10.1016/j.ijdevneu.2015.06.007
  • Peer Reviewed
• [Presentation] Symposium：Research for the mechanism and the treatment of human ovulatory disorders using rat model. - perspective of kisspeptin on clinical application - (2017)
  • Author(s): Toshiya Matsuzaki
  • Organizer: 3rd World Conference on Kisspeptin, “KISSPEPTIN 2017: Brain & Beyond”
  • Place of Presentation: Rosen Center Hotel (Orlando, Florida, USA)
  • Year and Date: 2017-03-30
• [Presentation] Symposium：Androgen Excess in Women-Polycystic Ovary Syndrome (2017)
  • Author(s): Minoru Irahara
  • Organizer: The 8th Congress of the International Society for Gender Medicine
  • Int'l Joint Research / Invited
• [Presentation] Symposium：PCOS and androgen excess” Maternal-Fetal Medicine/ Reproductive Endocrinology (2017)
  • Author(s): Minoru Irahara
  • Organizer: The 22nd Seoul International Symposium
  • Int'l Joint Research / Invited
• [Presentation] Invited lecture：New concept of diagnosis of PCOS (2017)
  • Author(s): Minoru Irahara
  • Organizer: The 103rd Annual Congress of KSOG
  • Int'l Joint Research / Invited
• [Presentation] 招聘講演：「日本産科婦人科学会からの提言」これからの生殖医療に求められる期待と責務 (2017)
  • Author(s): 苛原 稔
  • Organizer: 第35回日本受精着床学会総会・学術講演会
  • Invited
• [Presentation] ランチョンセミナー：これからの生殖内分泌学を考える (2017)
  • Author(s): 苛原 稔
  • Organizer: 第22回日本生殖内分泌学会学術集会
  • Invited
• [Presentation] Manipulating hypothalamus using rat models of anovulation and optimizing ovulation induction in human -Control of HPG axis to improve the fertility in animals and humans- (2017)
  • Author(s): Toshiya Matsuzaki
  • Organizer: Fourth World Congress of Reproductive Biology
  • Invited
• [Presentation] he influence of early-live infectious stress on the onset of puberty in male and female rats. (2017)
  • Author(s): Yiliyasi Mayila, Toshiya Matsuzaki, Takeshi Iwasa, Kiyohito Yano, Rie Yanagihara, Minoru Irahara
  • Organizer: he 8th Congress of the International Society for Gender Medicine
• [Presentation] 生涯研修プログラム：多嚢胞性卵巣症候群患者の代謝異常と長期的な管理-多嚢胞性卵巣症候群(polycystic ovary syndrome : PCOS )～基礎から臨床まで～－ (2017)
  • Author(s): 松崎利也
  • Organizer: 第69回日本産科婦人科学会学術講演会
  • Invited
• [Presentation] 雌ラットにおいてテストステロンが体重・摂食量に及ぼす影響は性腺ホルモン環境により変化する (2017)
  • Author(s): 岩佐 武、松崎利也、矢野清人、Munkhsaikhan Munkhzaya、Altankhuu Tungalagsuvd、 Yiliyasi Mayila, 苛原 稔
  • Organizer: 第21回日本生殖内分泌学会
• [Presentation] 正常月経女性および多嚢胞性卵巣症候群患者のアンドロゲン産生には複数のステロイド産生経路が関与する (2016)
  • Author(s): 齊藤和毅、松崎利也、岩佐 武、勝美桃理、宮戸真美、石川智則、苛原 稔、齊藤英和、久保田俊郎、緒方 勤、深見真紀
  • Organizer: 第61回日本生殖医学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-11-03
• [Presentation] 多嚢胞性卵巣症候群における血中抗ミュラー管ホルモン（AMH）測定の意義の検討 (2016)
  • Author(s): 矢野清人，松崎利也，岩佐 武，Tungalagsuvd Altankhuu，Munkhzaya Munkhsaikhan，Mayila Yiliyasi，苛原 稔
  • Organizer: 第61回日本生殖医学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-11-03
• [Presentation] Senktide and nor-BNI influenced LH secretion in fasted male rodents (2016)
  • Author(s): Altankhuu Tungalagsuvd、松崎利也、岩佐 武、Munkhsaikhan Munkhzaya、Yiliyasi Mayila、矢野清人、苛原 稔
  • Organizer: 第69回中国四国産科婦人科学会総会ならびに学術講演会
  • Place of Presentation: サポートホール高松、かがわ国際会議場（香川県高松市）
  • Year and Date: 2016-09-24
• [Presentation] 多嚢胞性卵巣症候群における血中AMH測定の意義の検討 (2016)
  • Author(s): 松崎利也、岩佐 武、馬依拉伊利亜斯、Altankhuu Tungalagsuvd、Munkhsaikhan Munkhzaya、苛原 稔
  • Organizer: 第68回日本産科婦人科学術講演会
  • Place of Presentation: 東京国際フォーラム（東京都千代田区）
  • Year and Date: 2016-04-21
• [Presentation] 多嚢胞性卵巣症候群における血中AMH測定の意義 (2015)
  • Author(s): 松崎利也、岩佐 武、馬依拉 伊利亜斯、Altankhuu Tungalagsuvd、Munkhsaikhan Munkhzaya、苛原 稔
  • Organizer: 第51回中国四国生殖医学会総会・学術講演会
  • Place of Presentation: 岡山国際交流センター（岡山県岡山市）
  • Year and Date: 2015-08-22
  • Invited
• [Presentation] Topics Session:Metformin treatment in women with polycystic ovary syndrome. (2015)
  • Author(s): Toshiya Matsuzaki
  • Organizer: IFFS/JSRM International Meeting,2015
  • Place of Presentation: PACIFICO Yokohama (Yokohama city, Kanagawa , Japan)
  • Year and Date: 2015-04-26
  • Int'l Joint Research / Invited
• [Presentation] Poster Tour : Senktide does not recover suppression of HPG axis induced by acute fasting in male rats. (2015)
  • Author(s): Altankhuu TUNGALAGSUVD, Toshiya MATSUZAKI, Takeshi IWASA, Munkhsaikhan MUNKHZAYA, Takako KAWAKITA, Minoru IRAHARA.
  • Organizer: IFFS/JSRM International Meeting,2015
  • Place of Presentation: PACIFICO Yokohama (Yokohama city, Kanagawa , Japan)
  • Year and Date: 2015-04-26
  • Int'l Joint Research
• [Book] 不妊・不育診療指針 (2016)
  • Author(s): 松崎利也
  • Total Pages: 766
  • Publisher: 中外医学社
• [Book] 今日の診断指針 第7版 (2015)
  • Author(s): 松崎 利也
  • Total Pages: 2013
  • Publisher: 医学書院