| Project/Area Number |
15K10674
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
カーン カレク 京都府立医科大学, 医学研究科, 准教授 (60336162)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 子宮内膜症 / 骨盤内炎症 / 卵巣予備能 / 腹水 / サイトカイン / ケモカイン / プロゲスチン / 炎症性腹水 / 卵巣チョコレート嚢胞 / 卵胞発育 / 炎症 |
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| Outline of Final Research Achievements |
Surgery for endometriomas may cause significant decline in serum AMH levels, ovarian reserve maker, just after the surgery and it may increase soon after primary decline, and then decrease again till steady levels at around one year after the surgery. The time points when one measure serum AMH levels to evaluate the effect of surgery on ovarian reserve is important.
Three step surgery utilizing dienogest may show less decline in serum AMH levels. Progestin may affect intraperitoneal pro-inflammatory cytokines and chemokines, such as IL-6, IL-8, and IP-10. IP-10 can be a marker for anti-inflammatory effects of progestins.
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