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Relationship between placenta accreta and mRNA/micro RNA

Research Project

Project/Area Number 15K10676
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionNagasaki University

Principal Investigator

YOSHIDA Atsushi  長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (50432977)

Co-Investigator(Kenkyū-buntansha) 三浦 清徳  長崎大学, 医歯薬学総合研究科(医学系), 准教授 (00363490)
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords癒着胎盤 / 術中超音波 / 胎盤特異的mRNA/miRNA / 前置胎盤 / 分子マーカー / micro RNA / 産婦人科 / microRNA / 母体血漿 / C19MC / 胎盤特異的
Outline of Final Research Achievements

1) In order to estimate the risk of placenta accreta at early pregnancy, we comprehensively identified placenta-specific genes flowing into maternal blood at early pregnancy. 2) The findings of intraoperative ultrasonography have made it possible to deny the possibility of adherent placenta that is difficult to remove.

Academic Significance and Societal Importance of the Research Achievements

妊娠初期の時点から分子マーカーを用いて癒着胎盤のリスクをスクリーニングし、妊娠16週以降の超音波検査で癒着胎盤の程度を評価するという新たなアプローチを前方視的に検証することを目的としたが、症例数
に限りがあり今回は検討できなかた。今後研究を継続して症例を追加することで、癒着胎盤の非侵襲的な妊婦検診法として受け入れられやすく、将来の臨床応用が十分に期待できる。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2016 2015 Other

All Journal Article (5 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 1 results) Remarks (2 results)

  • [Journal Article] ダグラス窩に嵌頓した卵巣腫瘍合併妊娠2016

    • Author(s)
      塚本大空、吉田敦、増﨑英明
    • Journal Title

      ペリネイタルケア

      Volume: 35 Pages: 521-525

    • Related Report
      2016 Research-status Report
  • [Journal Article] 絨毛膜瘤2016

    • Author(s)
      川下さやか,吉田敦,増﨑英明
    • Journal Title

      ペリネイタルケア

      Volume: 35 Pages: 617-621

    • Related Report
      2016 Research-status Report
  • [Journal Article] Authors' reply re: Transverse uterine fundal incision for placenta praevia with accreta, involving the entire anterior uterine wall: a case series.2015

    • Author(s)
      Nishijima K, Orisaka M, Takahashi J, Yamamoto M, Nakago S, Yoshida A, Masuzaki H, Kotsuji F, Yoshida Y.
    • Journal Title

      British journal of obstetrics and gynaecology

      Volume: 122 Issue: 13 Pages: 1844-5

    • DOI

      10.1111/1471-0528.13610

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of labor on plasma concentrations and postpartum clearance of cell-free, pregnancy-associated, placenta-specific microRNAs2015

    • Author(s)
      Morisaki S, Miura K, Higashijima A, Abe S, Miura S, Hasegawa Y, Yoshida A, Kaneuchi M, Yoshiura K, Masuzaki H
    • Journal Title

      Prenat Diagn

      Volume: 35 Issue: 1 Pages: 44-50

    • DOI

      10.1002/pd.4479

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Circulating levels of maternal plasma cell-free miR-21 are associated with maternal body mass index and neonatal birth weight.2015

    • Author(s)
      Miura K, Higashijima A, Hasegawa Y, Abe S, Miura S, Fuchi N, Murakami Y, Kinoshita A, Yoshida A, Kaneuchi M, Yoshiura KI, Masuzaki H.
    • Journal Title

      Prenatal Diagnosis

      Volume: 35 Issue: 5 Pages: 509-511

    • DOI

      10.1002/pd.4509

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Remarks] 長崎大学医学部産婦人科

    • URL

      http://www.med.nagasaki-u.ac.jp/gyneclgy/

    • Related Report
      2016 Research-status Report
  • [Remarks] 長崎大学病院産婦人科

    • URL

      http://www.med.nagasaki-u.ac.jp/gyneclgy/

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2020-03-30  

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