Cell proliferation mechanism via estrogen-related receptors in endometriosis
| Project/Area Number |
15K10681
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
Kitawaki Jo 京都府立医科大学, 医学(系)研究科(研究院), 教授 (00204925)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 子宮内膜症 / エストロゲン関連受容体 / GPER1 / アグリコン型イソフラボン |
|---|
| Outline of Final Research Achievements |
Endometriosis is one of estrogen-dependent diseases. In endometriosis tissue, the expression level of estrogen receptor (ER)β is higher than that of ERα. Endometriosis also expresses estrogen-related receptor (ERR) α, β, γ, and a transmembrane receptor GPER1.
Using primary cultured cell line derived from endometriosis and mouse endometriosis model, we demonstrated that G1, a GPER1 agonist, induces apoptosis by non-genomic action. Furthermore, we demonstrated that AglyMAX, an aglycone-type isoflavone with weak estrogen action, suppresses proliferation of endometriotic cells and cystic lesion of mouse model via the ERβ-NFκB pathway. AglyMAX inhibits various inflammatory factors.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] Abnormal lipid/lipoprotein metabolism and high plasma testosterone levels in male but not female aromatase-knockout mice2017
Author(s)
Amano A, Kondo Y, Noda Y, Ohta M, Kawanishi N, Machida S, Mitsuhashi K, Senmaru T, Fukui M, Takaoka O, Mori T, Kitawaki J, Ono M, Saibara T, Obayashi H, Ishigami A.
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Journal Title
Arch Biochem Biophys
Volume: -
Pages: 47-58
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Cystectomy of endometrioma, resection of DIE, and dienogest medication immediately after recurrence reduce repeat surgeries of endometrioma2017
Author(s)
Koshiba A, Kusuki I, Okimura H, Kataoka H, Takaoka O, Kokabu T, Ito F, Matsushima H, Kitawaki J
Organizer
18th Annual Congress of the Asia Pacific Association for Gynecologic Endoscopy and Minimally Invasive Therapy (APAGE 2017)
Related Report
Int'l Joint Research
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[Presentation] Exacerbation of endometriosis by dysfunction of regulatory T cells in mouse and human2016
Author(s)
Tanaka Y, Mori T, Akiyama K, Kataoka H, Takaoka O, Koshiba A, Ito F, Kusuki I, Iwasaku K, Mori T, Kitawaki J
Organizer
68th Annual Congress of Japan Society of Obstetrics and Gynecology
Place of Presentation
Tokyo
Year and Date
2016-04-22
Related Report
Int'l Joint Research
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[Presentation] Estrogen-related receptor alpha promotes angiogenesis and proliferation in uterine endometrial cancer2016
Author(s)
Matsushima H, Mori T, Ito F, Umemura S, Sasamoto K, Kokabu T, Akashi K, Sawada M, Tatsumi T, Kuroboshi H, Kitawaki J
Organizer
68th Annual Congress of Japan Society of Obstetrics and Gynecology
Place of Presentation
Tokyo
Year and Date
2016-04-22
Related Report
Int'l Joint Research
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