| Project/Area Number |
15K10685
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Keio University |
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Principal Investigator |
Ota Kuniaki 慶應義塾大学, 医学部(信濃町), 共同研究員 (90424142)
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| Co-Investigator(Kenkyū-buntansha) |
丸山 哲夫 慶應義塾大学, 医学部, 准教授 (10209702)
長島 隆 慶應義塾大学, 医学部, 共同研究員 (40338116)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | ビタミンD / テトラメチレンヒドロ葉酸代謝還元酵素 / ホモシステイン / 耐糖能異常 / プレコンセプションケア / 不育症 / メチレンテトラ葉酸還元酵素 / 妊娠 / 着床 / 生殖免疫 / Tリンパ球 / マクロファージ / T細胞 / NK細胞 |
|---|
| Outline of Final Research Achievements |
Vitamin D deficiency as the immune regulatory, elevation of homocysteine caused by gene polymorphism of tetramethylene hydrofolate metabolic reductase, impaired glucose tolerance to induce the circumstance of inflammation in vivo were clarified that there is an influence on the reproductive process of implantation and placentation. It is suggested that comprehensive nutritional education centered on vitamin D may be necessary for improving fertility, and it became the basis for the evidence of pre conception care.
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