The immune regulatory activated by Vitamin D has been the novel treatment for recurrent implantation failure and recurrent pregnancy losses
| Project/Area Number |
15K10685
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Keio University |
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Principal Investigator |
Ota Kuniaki 慶應義塾大学, 医学部(信濃町), 共同研究員 (90424142)
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| Co-Investigator(Kenkyū-buntansha) |
丸山 哲夫 慶應義塾大学, 医学部, 准教授 (10209702)
長島 隆 慶應義塾大学, 医学部, 共同研究員 (40338116)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | ビタミンD / テトラメチレンヒドロ葉酸代謝還元酵素 / ホモシステイン / 耐糖能異常 / プレコンセプションケア / 不育症 / メチレンテトラ葉酸還元酵素 / 妊娠 / 着床 / 生殖免疫 / Tリンパ球 / マクロファージ / T細胞 / NK細胞 |
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| Outline of Final Research Achievements |
Vitamin D deficiency as the immune regulatory, elevation of homocysteine caused by gene polymorphism of tetramethylene hydrofolate metabolic reductase, impaired glucose tolerance to induce the circumstance of inflammation in vivo were clarified that there is an influence on the reproductive process of implantation and placentation. It is suggested that comprehensive nutritional education centered on vitamin D may be necessary for improving fertility, and it became the basis for the evidence of pre conception care.
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] 1,25-Dihydroxy-vitamin D3 regulates NK-cell cytotoxicity, cytokine secretion, and degranulation in women with recurrent pregnancy losses.2015
Author(s)
Ota K, Dambaeva S, Kim MW, Han AR, Fukui A, Gilman-Sachs A, Beaman K, Kwak-Kim J
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Journal Title
Eur J Immunol
Volume: 45巻
Pages: 3188-3199
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] CD34 and CD49f double-positive and lineage marker-negative cells isolated from human myometrium exhibit stem cell-like properties involved in pregnancy-induced uterine remodeling.2015
Author(s)
Ono M, Kajitani T, Uchida H, Arase T, Oda H, Uchida S, Ota K, Nagashima T, Masuda H, Miyazaki K, Asada H, Hida N, Mabuchi Y, Morikawa S, Ito M, Bulun SE, Okano H, Matsuzaki Y, Yoshimura Y, Maruyama T
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Journal Title
Biology of Reproduction
Volume: 93巻
Pages: 37-37
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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