| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Outline of Final Research Achievements |
We provide evidence that the NLRP3 inflammasome pathway contributes to IL-1beta secretion in trophoblasts and that glibenclamide partially blocks this pathway. NLRP3 may be involved in placental inflammation such as infection-associated pregnancy complication. A1AT is highly expressed in decidual tissues rather than syncytiotrophoblasts, whereas HTRA1 expression is expressed in syncytiotrophoblasts and extravillous trophoblasts (EVT). Functional interaction between decidual A1AT and trophoblastic HTRA1 may regulate trophoblast invasion. Imbalance of both molecules activities might be involved in the progression of HDP, supporting the notion the possible role of A1AT and HTRA1 at the maternal-fetal interface.
|
