| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
The size of visceral adipocytes in postmenopausal women was significantly larger than that in premenopausal women (P < 0.05). The lipid peroxidation levels of visceral fat in postmenopal women were also significantly higher than that in premenopausal women (P < 0.05). We found that oxidative stress in visceral fat is higher in postmenopausal women. Estradiol (E2) significantly reduced the intracellular ROS levels that were induced by H2O2 in 3T3-L1 adipocytes (P < 0.01). We determined that E2 significantly increased the expression of nuclear factor erythroid 2-related factor 2 (NRF2)-dependent antioxidant genes, heme oxygenase-1 (HO-1), NAD(P)H:quinone oxidoreductase 1 (NQO-1), and the glutamate-cysteine ligase modifier subunit (GCL) genes in 3T3-L1 adipocytes (P < 0.01). Hence, estrogen may act as an antioxidant in the adipose tissues of premenopausal women.
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