Anti-oxidative stress pathway in the ovary to conquer inevitable aging

• Project/Area Number: 15K10704
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: The University of Tokyo
• Principal Investigator: Hiraike Osamu 東京大学, 医学部附属病院, 准教授 (20529060)
• Research Collaborator: HIRANO Mana 東京大学, 医学部附属病院, 助教 (80771253) ; AKINO Nana
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 卵巣 / 加齢性変化 / 酸化ストレス / 抗酸化機能 / 顆粒膜細胞 / Nrf2 / 抗酸化

Outline of Final Research Achievements

Nuclear factor-E2-related factor 2 (Nrf2) and its regulator Kelch-like ECH-associated protein 1 (Keap1) are one of the most important defense mechanisms against oxidative stress (OS). Dimethylfumarates (DMF) is an activator of Nrf2, and we investigated the possibility of DMF as a therapeutic drug for OS in human granulosa cells (GCs). We aimed to determine whether DMF alleviates OS in GCs. The mRNA and protein levels of Nrf2 and antioxidants were upregulated by H2O2 in human GCs, and DMF treatment showed similar results through activation of Nrf2. Knockdown of Nrf2 decreased the mRNA and protein levels of antioxidants in human GCs. DMF treatment of GCs activated Nrf2 and reduced intracellular ROS generation.
Our results show that activation of Nrf2 by DMF might lead to alleviated OS in human GCs, and this will lead to better outcomes in infertility treatment.

Research Products

• [Journal Article] Activation of Nrf2 might reduce oxidative stress in human granulosa cells (2018)
  • Author(s): Akino Nana、Wada-Hiraike Osamu、Terao Hiromi、Honjoh Harunori、Isono Wataru、Fu Houju、Hirano Mana、Miyamoto Yuichiro、Tanikawa Michihiro、Harada Miyuki、Hirata Tetsuya、Hirota Yasushi、Koga Kaori、Oda Katsutoshi、Kawana Kei、Fujii Tomoyuki、Osuga Yutaka
  • Journal Title: Mol Cell Endocrinol Volume: 470 Pages: 96
  • DOI: 10.1016/j.mce.2017.10.002
  • URL: https://localhost/en/publications/ac541c65-2e6a-449c-b0f2-ae6ad413bc1d
  • Peer Reviewed / Open Access
• [Journal Article] Therapeutic significance of targeting survivin in cervical cancer and possibility of combination therapy with TRAIL (2018)
  • Author(s): Nakamura H, Taguchi A, Kawana K, Baba S, Kawata A, Yoshida M, Fujimoto A, Ogishima J, Sato M, Inoue T, Nishida H, Furuya H, Yamashita A, Eguchi S, Tomio K, Mori-Uchino M, Adachi K, Arimoto T, Wada-Hiraike O, Oda K, Nagamatsu T, Osuga Y, Fujii T
  • Journal Title: Oncotarget Volume: 9 Issue: 17 Pages: 13451
  • DOI: 10.18632/oncotarget.24413
  • URL: https://pure.teikyo.jp/en/publications/abdeafea-7e17-4866-a6c7-fb940664b88e
  • Peer Reviewed / Open Access
• [Journal Article] Activation of Endoplasmic Reticulum Stress in Granulosa Cells from Patients with Polycystic Ovary Syndrome Contributes to Ovarian Fibrosis (2017)
  • Author(s): Takahashi Nozomi、Harada Miyuki、Hirota Yasushi、Nose Emi、Azhary Jerilee MK、Koike Hiroshi、Kunitomi Chisato、Yoshino Osamu、Izumi Gentaro、Hirata Tetsuya、Koga Kaori、Wada-Hiraike Osamu、Chang R. Jeffrey、Shimasaki Shunichi、Fujii Tomoyuki、Osuga Yutaka
  • Journal Title: Sci Rep Volume: 7 Issue: 1 Pages: 10824-10824
  • DOI: 10.1038/s41598-017-11252-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Administration of Oral Contraceptives Could Alleviate Age-Related Fertility Decline Possibly by Preventing Ovarian Damage in a Mouse Model (2017)
  • Author(s): Isono Wataru、Wada-Hiraike Osamu、Kawamura Yumiko、Fujii Tomoyuki、Osuga Yutaka、Kurihara Hiroki
  • Journal Title: Reproductive Sciences Volume: - Issue: 9 Pages: 1413-1423
  • DOI: 10.1177/1933719117746758
  • Peer Reviewed
• [Journal Article] Detachment from the primary site and suspension in ascites as the initial step in metabolic reprogramming and metastasis to the omentum in ovarian cancer (2017)
  • Author(s): Sato Masakazu、Kawana Kei、Adachi Katsuyuki、Fujimoto Asaha、Yoshida Mitsuyo、Nakamura Hiroe、Nishida Haruka、Inoue Tomoko、Taguchi Ayumi、Ogishima Juri、Eguchi Satoko、Yamashita Aki、Tomio Kensuke、Komatsu Atsushi、Wada?Hiraike Osamu、Oda Katsutoshi、Nagamatsu Takeshi、Osuga Yutaka、Fujii Tomoyuki
  • Journal Title: Oncology Letters Volume: 15 Issue: 1 Pages: 1357
  • DOI: 10.3892/ol.2017.7388
  • URL: https://localhost/en/publications/c3fdf792-1b78-4eca-9ea7-8681e898be3c
  • Peer Reviewed
• [Journal Article] Oncogenic histone methyltransferase EZH2: A novel prognostic marker with therapeutic potential in endometrial cancer. (2017)
  • Author(s): Oki S, Sone K, Oda K, Hamamoto R, Ikemura M, Maeda D, Takeuchi M, Tanikawa M, Mori-Uchino M, Nagasaka K, Miyasaka A, Kashiyama T, Ikeda Y, Arimoto T, Kuramoto H, Wada-Hiraike O, Kawana K, Fukayama M, Osuga Y, Fujii T.
  • Journal Title: Oncotarget Volume: in press Issue: 25 Pages: 40402-40411
  • DOI: 10.18632/oncotarget.16316
  • NAID: 120007089062
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Preoperative assessment of factors associated with difficulty in performing total laparoscopic hysterectomy. (2017)
  • Author(s): Saito A, Hirata T, Koga K, Takamura M, Fukuda S, Neriishi K, Pastorfide G, Harada M, Hirota Y, Wada-Hiraike O, Fujii T, Osuga Y
  • Journal Title: J Obstet Gynaecol Res. Volume: 43(2) Issue: 2 Pages: 320-329
  • DOI: 10.1111/jog.13198
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Low uptake of fluorodeoxyglucose in positron emission tomography/computed tomography in ovarian clear cell carcinoma may reflect glutaminolysis of its cancer stem cell-like properties, (2017)
  • Author(s): Sato M, Kawana K, Adachi K, Fujimoto A, Taguchi A, Fujikawa T, Yoshida M, Nakamura H, Nishida H, Inoue T, Ogishima J, Eguchi S, Yamashita A, Tomio K, Arimoto T, Wada-Hiraike Osamu, Oda K, Nagamatsu T, Osuga Y, Fujii T
  • Journal Title: Oncol Reports Volume: 37(3) Issue: 3 Pages: 1883-1888
  • DOI: 10.3892/or.2017.5398
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Drospirenone reduces inflammatory cytokines, vascular endothelial growth factor (VEGF) and nerve growth factor (NGF) expression in human endometriotic stromal cells. (2017)
  • Author(s): Makabe T, Koga K, Miyashita M, Takeuchi A, Sue F, Taguchi A, Urata Y, Izumi G, Takamura M, Harada M, Hirata T, Hirota Y, Wada-Hiraike O, Fujii T, Osuga Y.
  • Journal Title: J Reprod Immunol Volume: 119 Pages: 44-48
  • DOI: 10.1016/j.jri.2016.12.002
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A Potential Role for Endoplasmic Reticulum Stress in Progesterone Deficiency in Obese Women. (2017)
  • Author(s): Takahashi N, Harada M, Hirota Y, Zhao L, Azhary JM, Yoshino O, Izumi G, Hirata T, Koga K, Wada-Hiraike O, Fujii T, Osuga Y.
  • Journal Title: Endocrinology Volume: 158 Pages: 84-97
  • DOI: 10.1210/en.2016-1511
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Targeting glutamine metabolism and the focal adhesion kinase additively inhibits the mammalian target of the rapamycin pathway in spheroid cancer stem-like properties of ovarian clear cell carcinoma in vitro (2016)
  • Author(s): Sato M, Kawana K, Adachi K, Fujimoto A, Yoshida M, Nakamura H, Nishida H, Inoue T, Taguchi A, Ogishima J, Eguchi S, Yamashita A, Tomio K, Wada-Hiraike O, Oda K, Nagamatsu T, Osuga Y , Fujii T,
  • Journal Title: Int J Oncol Volume: 50 Issue: 4 Pages: 1431
  • DOI: 10.3892/ijo.2017.3891
  • URL: https://pure.teikyo.jp/en/publications/c52326ce-757a-4b85-a6ce-e5163d2648ad
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Vaginal stenosis after gonadotropin-releasing hormone agonist therapy during treatment for acute lymphoblastic Leukemia (2016)
  • Author(s): Sato M, Harada M, Oishi H, Wada-Hiraike O, Hirata T, Nagasaka K, Koga K, Fujii T, Osuga Y.
  • Journal Title: J Low Genit Tract Dis. Volume: 20 Issue: 2 Pages: 11-13
  • DOI: 10.1097/lgt.0000000000000175
  • URL: https://pure.teikyo.jp/en/publications/f814ef97-de31-4649-92b1-2a47f2974bde
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Resveratrol Enhances Apoptosis in Endometriotic Stromal Cells. (2016)
  • Author(s): Taguchi, A., Koga, K., Kawana, K., Makabe, T., Sue, F., Miyashita, M., Yoshida, M., Urata, Y., Izumi, G., Takamura, M., Harada, M., Hirata, T., Hirota, Y., Wada-Hiraike, O., Fujii, T., Osuga, Y
  • Journal Title: American Journal of Reproductive Immunology Volume: 75 Issue: 4 Pages: 486-492
  • DOI: 10.1111/aji.12489
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Vaginal cancer possibly caused by pessary and immunocompromised condition: Multiple risk factors may influence vaginal cancer development. (2016)
  • Author(s): Akino N, Wada-Hiraike O, Matsumoto Y, Arimoto T, Oda K, Kawana K, Osuga Y, Fujii T
  • Journal Title: J Obstet Gynaecol Res Volume: in press Issue: 6 Pages: 748-751
  • DOI: 10.1111/jog.12958
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Systemic delivery of siRNA by actively targeted polyion complex micelles for silencing the E6 and E7 human papillomavirus oncogenes (2016)
  • Author(s): Nishida H, Matsumoto Y, Kawana K, Christie RJ, Naito M, Kim BS, Toh K, Min HS, Yi Y, Matsumoto Y, Kim HJ, Miyata K, Taguchi A, Tomio K, Yamashita A, Inoue T, Nakamura H, Fujimoto A, Sato M, Yoshida M, Adachi K, Arimoto T, Wada-Hiraike O, Oda K, Nagamatsu T, Nishiyama N, Kataoka K, Osuga Y, Fujii T
  • Journal Title: J Control Release Volume: 231 Pages: 29
  • DOI: 10.1016/j.jconrel.2016.03.016
  • URL: https://pure.teikyo.jp/en/publications/1246fd42-3a7f-4b6e-b89e-7b96f138ec83
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A potential role of endoplasmic reticulum stress in development of ovarian hyperstimulation syndrome. (2016)
  • Author(s): Takahashi N, Harada M, Hirota Y, Zhao L, Yoshino O, Urata Y, Izumi G, Takamura M, Hirata T, Koga K, Wada-Hiraike O, Fujii T, Osuga Y.
  • Journal Title: Mol Cell Endocrinol Volume: 428 Pages: 161-169
  • DOI: 10.1016/j.mce.2016.03.032
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effects of 1,25-dihydroxy vitamin D3 on endometriosis. (2016)
  • Author(s): Miyashita M, Koga K, Izumi G, Sue F, Makabe T, Taguchi A, Nagai M, Urata Y, Takamura M, Harada M, Hirata T, Hirota Y, Wada-Hiraike O, Fujii T, Osuga Y.
  • Journal Title: J Clin Endocrinol Metab Volume: 101 Issue: 6 Pages: 2371-2379
  • DOI: 10.1210/jc.2016-1515
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Significance of survivin as a prognostic factor and a therapeutic target in endometrial cancer. (2016)
  • Author(s): Chuwa AH, Sone K, Oda K, Ikeda Y, Fukuda T, Wada-Hiraike O, Inaba K, Makii C, Takeuchi M, Oki S, Miyasaka A, Kashiyama T, Arimoto T, Kuramoto H, Kawana K, Yano T, Osuga Y, Fujii T.
  • Journal Title: Gynecol Oncol Volume: 141 Issue: 3 Pages: 564-569
  • DOI: 10.1016/j.ygyno.2016.04.003
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Characterization of TP53 and PI3K signaling pathways as molecular targets in gynecologic malignancies. (2016)
  • Author(s): Oda K, Ikeda Y, Kashiyama T et al.
  • Journal Title: The journal of obstetrics and gynecological research Volume: 42 Issue: 7 Pages: 757-62
  • DOI: 10.1111/jog.13018
  • Peer Reviewed
• [Journal Article] Synergistic antitumor effects of combination of PI3K/mTOR and MEK inhibition (SAR245409 and pimasertib) in mucinous ovarian carcinoma cells by fluorescence resonance energy transfer imaging. (2016)
  • Author(s): Inaba K, Oda K, Aoki K, Sone K, Ikeda Y, Miyasaka A, Kashiyama T, Fukuda T, Makii C, Arimoto T, Wada-Hiraike O, Kawana K, Yano T, Osuga Y, Fujii T
  • Journal Title: Oncotarget Volume: 7 Issue: 20 Pages: 29577-29591
  • DOI: 10.18632/oncotarget.8807
  • NAID: 120005820854
  • Peer Reviewed / Open Access
• [Journal Article] Spheroid cancer stem cells display reprogrammed metabolism and obtain energy by actively running the tricarboxylic acid (TCA) cycle (2016)
  • Author(s): Sato M, Kawana K, Adachi K, Fujimoto A, Yoshida M, Nakamura H, Nishida H, Inoue T, Taguchi A, Takahashi J, Kojima S, Yamashita A, Tomio K, Wada-Hiraike O, Oda K, Nagamatsu T, Osuga Y, Fujii T
  • Journal Title: Oncotarget Volume: 7 Issue: 22 Pages: 33297
  • DOI: 10.18632/oncotarget.8947
  • URL: https://pure.teikyo.jp/en/publications/c1e1b8f2-a962-4337-ab7a-6440e40a1899
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Inhibition of endoplasmic reticulum (ER) stress sensors sensitizes cancer stem-like cells to ER stress-mediated apoptosis (2016)
  • Author(s): Fujimoto A, Kawana K, Taguchi A, Adachi K, Sato M, Nakamura H, Ogishima J, Yoshida M, Inoue T, Nishida H, Tomio K, Yamashita A, Matsumoto Y, Arimoto T, Wada-Hiraike O, Oda K, Nagamatsu T, Osuga Y, Fujii T.
  • Journal Title: Oncotarget Volume: 7 Issue: 32 Pages: 51854
  • DOI: 10.18632/oncotarget.10126
  • URL: https://pure.teikyo.jp/en/publications/844aa8cb-5d34-44df-8878-79efb846a9a6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Neutrophil depletion reduces endometriotic lesion formation in mice. (2016)
  • Author(s): Takamura M, Koga K, Izumi G, Urata Y, Nagai M, Hasegawa A, Harada M, Hirata T, Hirota Y, Wada-Hiraike O, Fujii T, Osuga Y.
  • Journal Title: Am J Reprod Immunol Volume: 76 Issue: 3 Pages: 193-198
  • DOI: 10.1111/aji.12540
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Modification of the tumor microenvironment in KRAS or c-MYC-induced ovarian cancer-associated peritonitis (2016)
  • Author(s): Yoshida M, Taguchi A, Kawana K, Adachi K, Kawata A, Ogishima J, Nakamura H, Fujimoto A, Sato M, Inoue T, Nishida H, Furuya H, Tomio K, Arimoto T, Koga K, Wada-Hiraike O, Oda K, Nagamatsu T, Kiyono T, Osuga Y, Fujii T
  • Journal Title: Plos One Volume: 11 Issue: 8 Pages: e0160330-e0160330
  • DOI: 10.1371/journal.pone.0160330
  • URL: https://pure.teikyo.jp/en/publications/8e8def3d-a07f-48d6-ae12-6a860efc4a4d
  • Peer Reviewed / Open Access
• [Journal Article] Cancer-associated fibroblast suppresses killing activity of natural killer cells through downregulation of poliovirus receptor (PVR/CD155), a ligand of activating NK receptor (2016)
  • Author(s): Inoue T, Adachi K, Kawana K, Taguchi A, Nagamatsu T, Fujimoto A, Tomio K, Yamashita A, Eguchi S, Nishida H, Nakamura H, Sato M, Yoshida M, Arimoto T, Wada-Hiraike O, Oda K, Osuga Y, Fujii T.
  • Journal Title: Int J Oncol Volume: 49 Issue: 4 Pages: 1297
  • DOI: 10.3892/ijo.2016.3631
  • URL: https://pure.teikyo.jp/en/publications/05c3d1e0-eda8-409a-8bf1-2f47a70efd89
  • Peer Reviewed
• [Journal Article] Development of ovarian cancer after excision of endometrioma. (2016)
  • Author(s): Haraguchi H, Koga K, Takamura M, Makabe T, Sue F, Miyashita M, Urata Y, Izumi G, Harada M, Hirata T, Hirota Y, Wada-Hiraike O, Oda K, Kawana K, Fujii T, Osuga Y.
  • Journal Title: Fertil Steril Volume: 106 Issue: 6 Pages: 1432-1437
  • DOI: 10.1016/j.fertnstert.2016.07.1077
  • Peer Reviewed
• [Journal Article] Autophagy inhibition augments resveratrol-induced apoptosis in Ishikawa endometrial cancer cells. (2016)
  • Author(s): Fukuda T, Oda K, Wada-Hiraike O, Sone K, Inaba K, Ikeda Y, Makii C, Miyasaka A, Kashiyama T, Tanikawa M, Arimoto T, Yano T, Kawana K, Osuga Y, Fujii T.
  • Journal Title: Oncol Lett Volume: 12 Pages: 2560-2566
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• [Journal Article] MDM2 is a potential therapeutic target and prognostic factor for ovarian clear cell carcinomas with wild type TP53. (2016)
  • Author(s): Makii C, Oda K, Ikeda Y, Sone K, Hasegawa K, Uehara Y, Nishijima A, Asada K, Koso T, Fukuda T, Inaba K, Oki S, Machino H, Kojima M, Kashiyama T, Mori-Uchino M, Arimoto T, Wada-Hiraike O, Yano KK, Fujiwara K, Aburatani H, Osuga Y, Fujii T.
  • Journal Title: Oncotarget Volume: 7 Issue: 46 Pages: 75328-75338
  • DOI: 10.18632/oncotarget.12175
  • Peer Reviewed / Open Access
• [Journal Article] STAT3 activity regulates sensitivity to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in cervical cancer cells. (2016)
  • Author(s): Nakamura H, Taguchi A, Kawana K, Kawata A, Yoshida M, Fujimoto A, Ogishima J, Sato M, Inoue T, Nishida H, Furuya H, Tomio K, Eguchi S, Mori-Uchino M, Yamashita A, Adachi K, Arimoto T, Wada-Hiraike O, Oda K, Nagamatsu T, Osuga Y, Fujii T.
  • Journal Title: Int J Oncol Volume: 49 Issue: 5 Pages: 2155-2162
  • DOI: 10.3892/ijo.2016.3681
  • Peer Reviewed / Open Access
• [Journal Article] Assisted reproductive technology pregnancy complications are significantly associated with endometriosis severity before conception: a retrospective cohort study. (2016)
  • Author(s): Fujii T, Wada-Hiraike O, Nagamatsu T, Harada M, Hirata T, Koga K, Fujii T, Osuga Y.
  • Journal Title: Reprod Biol Endocrinol Volume: 14 Pages: 73-73
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Decreased expression of the plasminogen activator inhibitor type 1 is involved in degradation of extracellular matrix surrounding cervical cancer stem cells (2016)
  • Author(s): Sato M, Kawana K, Adachi K, Fujimoto A, Yoshida M, Nakamura H, Nishida H, Inoue T, Taguchi A, Takahashi J, Kojima S, Yamashita A, Tomio K, Nagamatsu T, Wada-Hiraike O, Oda K, Osuga Y, Fujii T.
  • Journal Title: Int J Oncol Volume: 48 Issue: 2 Pages: 829
  • DOI: 10.3892/ijo.2015.3283
  • URL: https://pure.teikyo.jp/en/publications/73438f06-cf7e-4f72-84f3-3b272b6942bd
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] CCAR2 negatively regulates nuclear receptor LXRα by competing with SIRT1 deacetylase (2015)
  • Author(s): Sakurabashi A, Wada-Hiraike O, Hirano M, Fu H, Isono W, Fukuda T, Morita Y, Tanikawa M, Miyamoto Y, Oda K, Kawana K, Osuga Y, Fujii T.
  • Journal Title: J Steroid Biochem Mol Biol Volume: 149 Pages: 80
  • DOI: 10.1016/j.jsbmb.2015.02.001
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  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The anti-malarial chloroquine suppresses proliferation and overcomes cisplatin resistance of endometrial cancer cells via autophagy inhibition. (2015)
  • Author(s): Fukuda T, Oda K, Wada-Hiraike O, Sone K, Inaba K, Ikeda Y, Miyasaka A, Kashiyama T, Tanikawa M, Arimoto T, Kuramoto H, Yano T, Kawana K, Osuga Y, Fujii T.
  • Journal Title: Gynecol Oncol Volume: 137 Issue: 3 Pages: 538-545
  • DOI: 10.1016/j.ygyno.2015.03.053
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] HPV-16 impairs the subcellular distribution and levels of expression of protein phosphatase 1γ in cervical malignancy (2015)
  • Author(s): Seiki T, Nagasaka K, Kranjec C, Kawana K, Maeda D, Nakamura H, Taguchi A, Matsumoto Y, Arimoto T, Wada-Hiraike O, Oda K, Nakagawa S, Yano T, Fukayama M, Banks L, Osuga Y, Fujii T.
  • Journal Title: BMC Cancer Volume: 15 Issue: 1 Pages: 230-230
  • DOI: 10.1186/s12885-015-1141-0
  • NAID: 120007089068
  • URL: https://pure.teikyo.jp/en/publications/a776250f-5cc7-45a4-9a39-cc1b73962d8a
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] PI3K/mTOR pathway inhibition overcomes radioresistance via suppression of the HIF1-α/VEGF pathway in endometrial cancer. (2015)
  • Author(s): Miyasaka A, Oda K, Ikeda Y, Sone K, Fukuda T, Inaba K, Makii C, Enomoto A, Hosoya N, Tanikawa M, Uehara Y, Arimoto T, Kuramoto H, Wada-Hiraike O, Miyagawa K, Yano T, Kawana K, Osuga Y, Fujii T.
  • Journal Title: Gynecol Oncol Volume: 138 Issue: 1 Pages: 174-180
  • DOI: 10.1016/j.ygyno.2015.04.015
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Four Cases of Postoperative Pneumothorax Among 2814 Consecutive Laparoscopic Gynecologic Surgeries: A Possible Correlation Between Postoperative Pneumothorax and Endometriosis. (2015)
  • Author(s): Hirata T, Nakazawa A, Fukuda S, Hirota Y, Izumi G, Takamura M, Harada M, Koga K, Wada-Hiraike O, Fujii T, Osuga Y.
  • Journal Title: J Minim Invasive Gynecol Volume: 22 Issue: 6 Pages: 980-984
  • DOI: 10.1016/j.jmig.2015.04.023
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Antitumor activity of a combination of dual PI3K/mTOR inhibitor SAR245409 and selective MEK1/2 inhibitor pimasertib in endometrial carcinomas. (2015)
  • Author(s): Inaba K, Oda K, Ikeda Y, Sone K, Miyasaka A, Kashiyama T, Fukuda T, Uehara Y, Arimoto T, Kuramoto H, Wada-Hiraike O, Kawana K, Yano T, Osuga Y, Fujii T.
  • Journal Title: Gynecol Oncol Volume: 138 Issue: 2 Pages: 323-331
  • DOI: 10.1016/j.ygyno.2015.05.031
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Resveratrol Protects Against Pathological Preterm Birth by Suppression of Macrophage-Mediated Inflammation. (2015)
  • Author(s): Furuya H, Taguchi A, Kawana K, Yamashita A, Inoue E, Yoshida M, Nakamura H, Fujimoto A, Inoue T, Sato M, Nishida H, Nagasaka K, Adachi K, Hoya M, Nagamatsu T, Wada-Hiraike O, Yamashita T, Osuga Y, Fujii T.
  • Journal Title: Reprod Sci Volume: 22 Issue: 12 Pages: 1561-1568
  • DOI: 10.1177/1933719115589413
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• [Journal Article] ntegrated copy number and expression analysis identifies profiles of whole-arm chromosomal alterations and subgroups with favorable outcome in ovarian clear cell carcinomas. (2015)
  • Author(s): Uehara Y, Oda K, Ikeda Y, Koso T, Tsuji S, Yamamoto S, Asada K, Sone K, Kurikawa R, Makii C, Hagiwara O, Tanikawa M, Maeda D, Hasegawa K, Nakagawa S, Wada-Hiraike O, Kawana K, Fukayama M, Fujiwara K, Yano T, Osuga Y, Fujii T, Aburatani H.
  • Journal Title: PLoS One Volume: 10 Issue: 6 Pages: e0128066-e0128066
  • DOI: 10.1371/journal.pone.0128066
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] HAND2-mediated proteolysis negatively regulates the function of estrogen receptor α (2015)
  • Author(s): Fukuda T, Shirane A, Wada-Hiraike O, Oda K, Tanikawa M, Sakuabashi A, Hirano M, Fu H, Morita Y, Miyamoto Y, Inaba K, Kawana K, Osuga Y, Fujii T.
  • Journal Title: Mol Med Rep Volume: 12 Issue: 4 Pages: 5538
  • DOI: 10.3892/mmr.2015.4070
  • URL: https://pure.teikyo.jp/en/publications/8bd56c36-b89d-4b79-ad92-0a2f700957b5
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Putative tumor suppression function of SIRT6 in endometrial cancer. (2015)
  • Author(s): Fukuda T, Wada-Hiraike O, Oda K, Tanikawa M, Makii C, Inaba K, Miyasaka A, Miyamoto Y, Yano T, Maeda D, Sasaki T, Kawana K, Fukayama M, Osuga Y, Fujii T.
  • Journal Title: FEBS Lett Volume: 589 Issue: 17 Pages: 2274-2281
  • DOI: 10.1016/j.febslet.2015.06.043
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Clinical significance of Gremlin 1 in cervical cancer and its effects on cancer stem cell maintenance (2015)
  • Author(s): Sato M, Kawana K, Fujimoto A, Yoshida M, Nakamura H, Nishida H, Inoue T, Taguchi A, Takahashi J, Adachi K, Nagasaka K, Matsumoto Y, Wada-Hiraike O, Oda K, Osuga Y, Fujii T.
  • Journal Title: Oncol Rep Volume: 35 Issue: 1 Pages: 391
  • DOI: 10.3892/or.2015.4367
  • URL: https://pure.teikyo.jp/en/publications/c68fdd5f-17b3-49da-96e1-65c79c762575
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Prognostic importance of CDK4/6-specific activity as a predictive marker for recurrence in patients with endometrial cancer, with or without adjuvant chemotherapy. (2015)
  • Author(s): keda Y, Oda K, Ishihara H, Wada-Hiraike O, Miyasaka A, Kashiyama T, Inaba K, Fukuda T, Sone K, Matsumoto Y, Arimoto T, Maeda D, Ikemura M, Fukayama M, Kawana K, Yano T, Aoki D, Osuga Y, Fujii T.
  • Journal Title: Br J Cancer Volume: 113 Issue: 10 Pages: 1477-1483
  • DOI: 10.1038/bjc.2015.369
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 平成26年度学会奨励賞(基礎研究部門)受賞講演 エストロゲン標的組織の病態発症に関与する分子制御機構解明を目的とした基礎的研究 (2015)
  • Author(s): 平池 修
  • Journal Title: 日本女性医学学会雑誌 Volume: 23 Pages: 51-54
  • NAID: 40020688245
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Art pregnancy complication are significantly associated with endometriosis severity before conception: A retrospective study (2017)
  • Author(s): Osamu Wada-Hiraike, Tatsuya Fujii, Takeshi Nagamatsu, Miyuki Harada, Tetsuya Hirata, Kaori Koga, Tomoyuki Fujii, Yutaka Osuga
  • Organizer: 64th Annual Meeting of the Society for Reproductive Investigation
  • Place of Presentation: 米国（フロリダ）
  • Year and Date: 2017-03-15
  • Int'l Joint Research
• [Presentation] 日常診療に役立つOC/LEPの使用法 (2017)
  • Author(s): 平池 修
  • Organizer: 奈良県産婦人科学会
  • Invited
• [Presentation] 腹腔鏡下手術の基本と近年の発展 (2017)
  • Author(s): 平池 修
  • Organizer: 関東連合産婦人科学会
  • Invited
• [Presentation] Recent advances in JSGOE system (2017)
  • Author(s): Osamu Hiraike
  • Organizer: 18th Asia Pacific Association of Endoscopy
  • Invited
• [Presentation] 内視鏡技術認定医を目指す上でのワーク・ライフ・バランス (2017)
  • Author(s): 平池 修
  • Organizer: 日本産科婦人科内視鏡学会
  • Invited
• [Presentation] 女性ホルモン・エストロゲンと女性の健康包括的支援 (2017)
  • Author(s): 平池 修
  • Organizer: 更年期と加齢のヘルスケア学会
  • Invited
• [Presentation] ホルモン補充療法と乳がんリスク (2017)
  • Author(s): 平池 修
  • Organizer: 日本女性医学学会
  • Invited
• [Presentation] 卵巣における抗老化因子の役割 (2016)
  • Author(s): 平池 修
  • Organizer: 第26回臨床内分泌代謝Update
  • Place of Presentation: 埼玉
  • Year and Date: 2016-11-18
  • Invited
• [Presentation] 日本産科婦人科内視鏡学会の取り組む安全性担保 技術認定制度・施設認定制度・第三者評価委員会 (2016)
  • Author(s): 平池 修
  • Organizer: 第56回 日本産科婦人科内視鏡学会 学術講演会
  • Place of Presentation: 長崎
  • Year and Date: 2016-09-01
  • Invited
• [Presentation] 指導者の立場からみた腹腔鏡下子宮全摘術の安全な遂行 (2016)
  • Author(s): 平池 修
  • Organizer: 第56回 日本産科婦人科内視鏡学会 学術講演会
  • Place of Presentation: 長崎
  • Year and Date: 2016-09-01
  • Invited
• [Presentation] Farnesoid X Receptor Agonist GW4064 Contributes to Steroidogenesis Pathways in Human Luteinized Granulosa Cells. (2016)
  • Author(s): Wada-Hiraike O, Fu H, Hirano H, Akino N, Harada M, Koga K, Fujii T, Osuga Y.
  • Organizer: 第63回 Society for Reproductive Investigation
  • Place of Presentation: カナダ モントリオール
  • Year and Date: 2016-03-16
  • Int'l Joint Research
• [Presentation] 日本産科婦人科内視鏡学会における施設認定制度運用の要点 (2015)
  • Author(s): 平池 修
  • Organizer: 第55回 日本産科婦人科内視鏡学会
  • Place of Presentation: パシフィコ横浜（神奈川・横浜）
  • Year and Date: 2015-09-09
  • Invited
• [Book] TSEC: tissue specific estrogen complex (2016)
  • Author(s): 宮本 雄一郎、平池 修
  • Total Pages: 99
  • Publisher: メディカルレビュー社
• [Book] 婦人科腹腔鏡手術の展望 (2015)
  • Author(s): 平池 修、大須賀 穣
  • Total Pages: 128
  • Publisher: 診断と治療社
• [Book] 女性ヘルスケア 集中講義 エストロゲン受容体およびその活性制御に関連した転写因子の分子機構について (2015)
  • Author(s): 平池 修
  • Total Pages: 517
  • Publisher: 金原出版
• [Book] アンチエイジング医学の基礎と臨床第3版 女性ホルモンの医学 (2015)
  • Author(s): 平池 修、大須賀 穣
  • Total Pages: 466
  • Publisher: メジカルビュー社
• [Book] 抗加齢物質としてのエストロゲン (2015)
  • Author(s): 平池 修
  • Total Pages: 52
  • Publisher: フジメディカル出版
• [Book] 臨床検査ガイド 下垂体 黄体形成ホルモン（LH), 卵胞刺激ホルモン（FSH) (2015)
  • Author(s): 平池 修
  • Total Pages: 1154
  • Publisher: 文光堂